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Scientists, investors, policymakers, the media, and the general public have all displayed a continuing interest in the commercial promise and potential dangers of genetic engineering. In this book, Herbert Gottweis explains how genetic engineering became so controversial—a technology that some seek to promote by any means and others want to block entirely. Beginning with a clear exposition of poststructuralist theory and its implications for research methodology, Gottweis offers a novel approach to political analysis, emphasizing the essential role of narratives in the development of policy under contemporary conditions. Drawing on more than eighty in-depth interviews and extensive archival work, Gottweis traces today's controversy back to the sociopolitical and scientific origins of molecular biology, paying particular attention to its relationship to eugenics. He argues that over the decades a number of mutually reinforcing political and scientific strategies have attempted to turn genes into objects of technological intervention—to make them "governable." Looking at critical events such as the 1975 Asilomar conference in the United States, the escalating conflict in Germany, and regulatory disputes in Britain and France during the 1980s, Gottweis argues that it was the struggle over boundaries and representations of genetic engineering, politics, and society that defined the political dynamics of the drafting of risk regulations in these countries. In a key chapter on biotechnology research, industry, and supporting technology policies, Gottweis demonstrates that the interpretation of genetic engineering as the core of a new "high technology" industry was part of a policy myth and an expression of identity politics. He suggests that under postmodern conditions a major strategy for avoiding policy failure is to create conditions that ensure tolerance and respect for the multiplicity of socially available policy narratives and reality interpretations.
In line with recent evidence, the development of cancer has been described as uncontrolled cell growth that results from gradual accumulation of genetic and epigenetic alterations, involving aberrations in oncogenes, tumor suppressor genes, and defects in genes engaged in DNA repair. As a result, cancer cells acquire a neoplastic phenotype and tumor-associated antigens (TAAs) are presented on their surface. These target structures should be recognized by cells of the immune system. However, a sequence of events at the genetic and epigenetic level disturb immune cells, and in consequence, make them unable to eliminate cancer cells. Both innate and adaptive immunity are mobilized against cancer cells. In response to the appearance of cells with malignant transformation, NK cells release perforin and granzyme, causing direct cytolysis of the target cells. They can also secrete pro-inflammatory cytokines and in that way enhance the anticancer response. The activity of NK cells is regulated by a variety of activating and inhibitory receptors including NKG2D, KIR, CD94 -NKG2 heterodimers and natural cytotoxicity receptors, TNF family ligands, as well as co-stimulatory receptors, which recognize related molecules on target cells. A fundamental trigger of the anticancer immune response is the recognition of TAAs by T cells, via the major histocompatibility complex (MHC), which should be followed by signals from co-stimulatory molecules. Full activation of T lymphocytes requires a third signal provided by the presence of cytokines, and this leads to cell proliferation, differentiation, and secretion of chemokines and cytokines. The effect is to drive the clonal expansion of the T cells directed against TAAs and to recruit other immune effector cells in order to enhance immune defense.
Contributors look at how the 'new' genetics, healthcare and arising health policy can or should be governed and regulated, rather than focusing on individualistic ethical issues, this text takes a broader, international public health approach.
This comparative study looks at the early development of biotechnology in the US and Japan. Drawing on primary and secondary sources it traces the historical roots of recombinant DNA technology, discusses the tensions between regulation and promotional policies and identifies the major actors and strategies that launched biotechnology in both countries. Developing several strands of theory in economic history, science and technology policy, the book proposes a simple model that relates the differences in the two countries' responses to variations in the availability of institutional, financial and organizational resources needed to commercialize the new technology.
Sequencing is often associated with the Human Genome Project and celebrated achievements concerning the DNA molecule. However, the history of this practice comprises not only academic biology, but also the world of computer-assisted information management. The book uncovers this history, qualifying the hype and expectations around genomics.
What are the roles of governments and other actors in solving, or alleviating, collective action problems in today’s world? The traditional conceptual frameworks of public administration and public policy studies have become less relevant in answering this question. This book critically assesses traditional conceptual frameworks and proposes an alternative: a complex governance networks (CGN) framework. Advocating that complexity theory should be systematically integrated with foundational concepts of public administration and public policy, Göktuğ Morçöl begins by clarifying the component concepts of CGN and then addresses the implications of CGN for key issues in public administration and policy studies: effectiveness, accountability, and democracy. He illustrates the applicability of the CGN concepts with examples for the COVID-19 pandemic and metropolitan governance, particularly the roles of business improvement districts in governance processes. Morçöl concludes by discussing the implications of CGN for the convergence of public administration and public policy education and offering suggestions for future studies using the CGN conceptualization. Complex Governance Networks is essential reading for both scholars and advanced students of public policy, public administration, public affairs, and related areas.
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This collection analyses and comments on the development of the ERA, which seeks to co-ordinate national research and advance European wide projects. The contributors include leading scholars of European integration and technology policy and high-level administrators. They discuss the potential impacts, benefits and limits to research and innovation policy within Europe both in the short and long term. Moreover, the debate about ERA is placed firmly in the context of the overall changes at the European level.