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Through innovative interdisciplinary methodologies and fresh avenues of inquiry, the nine essays collected in A Peculiar Mixture endeavor to transform how we understand the bewildering multiplicity and complexity that characterized the experience of German-speaking people in the middle colonies. They explore how the various cultural expressions of German speakers helped them bridge regional, religious, and denominational divides and eventually find a way to partake in America’s emerging national identity. Instead of thinking about early American culture and literature as evolving continuously as a singular entity, the contributions to this volume conceive of it as an ever-shifting and tangled “web of contact zones.” They present a society with a plurality of different native and colonial cultures interacting not only with one another but also with cultures and traditions from outside the colonies, in a “peculiar mixture” of Old World practices and New World influences. Aside from the editors, the contributors are Rosalind J. Beiler, Patrick M. Erben, Cynthia G. Falk, Marie Basile McDaniel, Philip Otterness, Liam Riordan, Matthias Schönhofer, and Marianne S. Wokeck.
'A New History of German Literature' offers some 200 essays on events in German literary history.
Preface: Natural products chemistry has a long history, and could be regarded as having its roots in the use of many kinds of herbal mixtures as crude drugs in traditional medicine. Systems of traditional medicine have been practiced in China and Japan for thousands of years, and virtually all regions of the world have used natural materials to treat human disease. It was clear that many plants, herbs, etc. contain components with powerful biological activities. The dawn of modern natural products chemistry began with the isolation of the active component, morphine, from opium. Subsequently, various alkaloids were isolated from medicinal plants and employed clinically. The discovery and the development of penicillin as a microbial metabolite opened up the era of antibiotics, which have saved countless lives in the past half century or so. The isolation and synthesis of steroid hormones resulted in the development of new concepts in molecular stereochemistry and organic synthetic techniques, as did the discovery of bioactive lipids such as prostaglandins and leukatrienes, bioactive peptides such as enkephalins and endetherines, and oligosaccharides, including glycoproteins. Further, the discovery of plant hormones has led to great strides in plant biotechnology, including plant tissue cultures, and derivatives of insect hormones and pheromones are now used as pesticides. Thus, applications of natural products chemistry have become all-pervasive in modern society. Apart from the extensive practical applications of natural products and their derivatives, natural products chemistry has played a central role in the development of modern organic chemistry as a result of its focus on structural and synthetic studies of often highly complex and inaccessible molecules. Biosynthetic studies have also attracted much attention, aiming to answer the questions of why and how such a large number and variety of compounds are synthesised by organisms. Researchers in the field of biosynthesis first focused on elucidation of the pathways of secondary metabolism, and then on the mechanisms, of the enzymes catalyzing the biosynthetic reactions. This was an extremely difficult task, because rather large amounts of enzymes are required for the investigation of reaction mechanisms and the enzyme proteins are often unstable and not easy to purify. However, in recent years the development of molecular biology has made gene and protein engineering rather routine. Thus, studies of mechanistic enzymology can now be conducted with cloned and overexpressed enzyme proteins. It has been shown that the enzymes responsible for the biosynthesis of antibiotics in Streptomyces spp. are encoded in gene clusters. Further, cloning and functional analysis of the genes associated with flavonoid biosynthesis should soon cast light on the interesting question of why flavonoids are ubiquitously present in plant leaves. Life is maintained not only by large molecules such as proteins and nucleic acids, but also by many small molecules which have essential and diverse roles in the physiology of living organisms. Such compounds often have highly specific interactions with target receptors, but the mechanisms involved largely remain to be explored. Current methodology means that this task can be addressed, and this in turn should lead to a host of new applications for natural products and their derivatives. The key may be an interdisciplinary approach taking account of both biological function and molecular behaviour based on precise structure recognition. As we increasingly understand the mechanisms of molecular recognition that operate in nature, many possibilities should open up for artificial control or modification of biological functions, as well as new challenges for synthetic organic chemists. Our intention in this book is to focus on such dynamic aspects of natural products chemistry. By dealing in detail with representative topics to which the most modern techniques of research have been applied, we hope to emphasize the value of combining traditional approaches to natural products chemists with current biochemical and molecular-biological ideas. Each chapter provides sufficient background information and experimental detail to make the subject accessible to non-specialists. It is our hope that these examples of recent progress in key areas of natural products chemistry will stimulate work in related topics by illustrating the power of a modern interdisciplinary approach to the subject.
First published in 2001. Routledge is an imprint of Taylor & Francis, an informa company.
This two-volume set presents a comprehensive and up-to-date history of eighteenth-century philosophy. The subject is treated systematically by topic, not by individual thinker, school, or movement, thus enabling a much more historically nuanced picture of the period to be painted.
The Palgrave Handbook of European Migration in Literature and Culture engages with migration to, within, and from Europe, foregrounding migration through the lenses of historical migratory movement and flows associated with colonialism and postcolonialism. With essays on literature, film, drama, graphic novels, and more, the book addresses migration and media, hostile environments, migration and language, migration and literary experiment, migration as palimpsest, and figurations of the migrant. Each section is introduced by one of the handbook’s contributing editors and interviews with writers and film directors are integrated throughout the volume. The essays collected in the volume move beyond the discourse of the “refugee crisis” to trace the historical roots of the current migration situation through colonialism and decolonization.
At the end of his second year in Leipzig, J.S. Bach composed nine sacred cantatas to texts by Leipzig poet Mariane von Ziegler (1695-1760). Despite the fact that these cantatas are Bach's only compositions to texts by a female poet, the works have been largely ignored in the Bach literature. Ziegler was Germany's first female poet laureate, and the book highlights her significance in early eighteenth-century Germany and her commitment to advancing women's rights of self-expression. Peters enriches and enlivens the account with extracts from Ziegler's four published volumes of poetry and prose, and analyses her approach to cantata text composition by arguing that her distinctive conception of the cantata as a genre encouraged Bach's creative musical realizations. In considering Bach's settings of Ziegler's texts, Peters argues that Bach was here pursuing a number of compositional procedures not common in his other sacred cantatas, including experimentation with the order of movements within a cantata, with formal considerations in arias and recitatives, and with the use of instruments, as well as innovative approaches to Vox Christi texts and to texts dealing with speech and silence. A Woman's Voice in Baroque Music is the first book to deal in depth with issues of women in music in relation to Bach, and one of the few comprehensive studies of a specific repertory of Bach's sacred cantatas. It therefore provides a significant new perspective on both Ziegler as poet and cantata librettist and Bach as cantata composer.