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" Among the darkest corners of Kentucky’s past are the grisly feuds that tore apart the hills of Eastern Kentucky from the late nineteenth century until well into the twentieth. Now, from the tangled threads of conflicting testimony, John Ed Pearce, Kentucky’s best known journalist, weaves engrossing accounts of six of the most notorior accounts to uncover what really happened and why. His story of those days of darkness brings to light new evidence, questions commonly held beliefs about the feuds, and us and long-running feuds—those in Breathitt, Clay Harlan, Perry, Pike, and Rowan counties. What caused the feuds that left Kentucky with its lingering reputation for violence? Who were the feudists, and what forces—social, political, financial—hurled them at each other? Did Big Jim Howard really kill Governor William Goebel? Did Joe Eversole die trying to protect small mountain landowners from ruthless Eastern mineral exploiters? Did the Hatfield-McCoy fight start over a hog? For years, Pearce has interviewed descendants of feuding families and examined skimpy court records and often fictional newspapeputs to rest some of the more popular legends.
In the past few years an increasing number of colleges and universities have added courses in biomedical ethics to their curricula. To some extent, these additions serve to satisfy student demands for "relevance. " But it is also true that such changes reflect a deepening desire on the part of the academic community to deal effectively with a host of problems which must be solved if we are to have a health-care delivery system which is efficient, humane, and just. To a large degree, these problems are the unique result of both rapidly changing moral values and dramatic advances in biomedical technology. The past decade has witnessed sudden and conspicuous controversy over the morality and legality of new practices relating to abortion, therapy for the mentally ill, experimentation using human subjects, forms of genetic interven tion, suicide, and euthanasia. Malpractice suits abound and astronomical fees for malpractice insurance threaten the very possibility of medical and health-care practice. Without the backing of a clear moral consensus, the law is frequently forced into resolving these conflicts only to see the moral issues involved still hotly debated and the validity of existing law further questioned. In the case of abortion, for example, the laws have changed radically, and the widely pub licized recent conviction of Dr. Edelin in Boston has done little to foster a moral consensus or even render the exact status of the law beyond reasonable question.
An Unspoiled Waterway teeming with fish, its shores a virtual paradise, the Anacostia River figured prominently in the original plans for the new nation's elegant, bustling capital. Instead it quickly became a poster child for America's tragically neglected and abused urban waterways. With a clear eye and sharp pen, accomplished environmental historian John R. Wennersten takes an unsparing look at the historic forces and misguided policies that all but ruined a beautiful river while imposing the burden of pollution unequally on Washington's poorer citizens. Anacostia offers a much needed corrective to the uncritical assumptions of growth for its own sake and the cost it imposes on our waters, our natural resources, and the health of our citizenry. It also demonstrates how thoughtless destruction can be stopped, and rivers restored. Book jacket.
To facilitate the development of novel drug delivery systems and biotechnology-oriented drugs, the need for new, yet to be developed, and approved excipients continues to increase. Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems serves as a comprehensive source to improve understanding of excipients and forge potential new avenues for regulatory approval. This book presents detailed, up-to-date information on various aspects of excipient development, testing, and technological considerations for their use. It addresses specific details such as historical perspective, preclinical testing, safety, and toxicology evaluation, as well as regulatory, quality, and utility aspects. The text also describes best practices for use of various functional excipients and extensive literature references for all topics.