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"This is a Ph.D. dissertation. Reversible protein phosphorylation has become widely recognized as the most important reaction for the regulation of protein functioning in eukaryotic cells, being involved in switching cellular activities from one state to another and, in this way, regulating different cellular functions. It is the major mechanism by which cells respond to extracellular signals, such as hormones and growth factors, and control all events at various stages of the cell cycle, as well as the response of the cell to environmental and nutritional stresses. As much as one-third of cellular proteins have been estimated to undergo reversible protein phosphorylation, underlining the importance, and widespread occurrence of this modification. Contents include: General Introduction, Protein Phosphates, Multimetric Structure of PP2A, PP2A as a Kinase Phosphate, Aims of the Work, Materials and Methods, Results, B'/PR61-Interacting Proteins, Discussion."
"This is a Ph.D. dissertation. This thesis deals with the eukaryotic protein NIPP1 (Nuclear Inhibitor of Protein Phosphate-1), which was initially described by the host laboratory in 1992 and still is the major focus of its research efforts. The first part of the introduction describes our current insights into the structure and function of NIPP1, with the exception of aspects that directly deal with this doctoral project. For reasons of clarity, the data are presented in a logical manner, which implies that they are not necessarily presented according to their order of discovery. In the final sections of the introduction, a brief overview will be given of the state of the art of the `structure and function of ribonucleases' and `transcriptional repression mechanisms,' two topics that directly related to this research project. Contents include: Introduction, The Structure and Function of NIPP1, The Structure and Function of Ribonucleases, Transcriptional Repression in Eukaryotes, Aims and Strategies, Materials and Methods, Results and Discussions, Mapping of the RNA-binding and Endoribonuclease Domain of NIPP1, Screening for Proteins that Interact with the C-Terminal domain of NIPP1."
This is a Ph.D. dissertation. S. pneumoniae is a major causative agent of serious infections. Besides, the emerging resistance of S. pneumoniae to multiple antibiotic drugs is a major concern in the treatment of infections caused by this micro-organism. Therefore it is important to study the molecular mechanisms that meditate the antibody response to caps-PS. The aim of the study is to better understand the regulation and the molecular mechanisms of the immune response to pneumococcal caps-PS. The present study was undertaken to determine the role of the CD40-CD40L interaction in the murine antibody response to pneumococcal caps-PS antigens.