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"I think this is an excellent book–I recommend it to anyone involved in molecular epidemiology... The 26 chapters are written by topic specialists, in an explanatory, east to read style." –BTS Newsletter, Summer 2009 "This text provides an accessible and useful handbook for the epidemiologist who wants to survey the field, to become better informed, to look at recent developments and get some background on these or simply to appreciate further the relatively rapid changes in informatic and analytical technologies which increasingly will serve and underpin future epidemiological studies. One of the strengths in this book is the extensive array of practical illustrative examples, and it would also in my opinion have useful potential as a teaching text." –American Journal of Human Biology, March 2009 With the sequencing of the human genome and the mapping of millions of single nucleotide polymorphisms, epidemiology has moved into the molecular domain. Scientists can now use molecular markers to track disease-associated genes in populations, enabling them to study complex chronic diseases that might result from the weak interactions of many genes with the environment. Use of these laboratory generated biomarker data and an understanding of disease mechanisms are increasingly important in elucidating disease aetiology. Molecular Epidemiology of Disease crosses the disciplinary boundaries between laboratory scientists, epidemiologists, clinical researchers and biostatisticians and is accessible to all these relevant research communities in focusing on practical issues of application, rather than reviews of current areas of research. Covers categories of biomarkers of exposure, susceptibility and disease Includes chapters on novel technologies: genomics, transcriptomics, proteomics and metabonomics, which are increasingly finding application in population studies Emphasizes new statistical and bioinformatics approaches necessitated by the large data sets generated using these new methodologies Demonstrates the potential applications of laboratory techniques in tackling epidemiological problems while considering their limitations, including the sources of uncertainty and inaccuracy Discusses issues such as reliability (compared to traditional epidemiological methods) and the timing of exposure Explores practical elements of conducting population studies, including biological repositories and ethics Molecular Epidemiology of Disease provides an easy-to-use, clearly presented handbook that allows epidemiologists to understand the specifics of research involving biomarkers, and laboratory scientists to understand the main issues of epidemiological study design and analysis. It also provides a useful tool for courses on molecular epidemiology, using many examples from population studies to illustrate key concepts and principles.
The tracheobronchial tree is open to the environment surrounding the body. Respiration has thus the essential bearing on general morbidity, vulnerability to disease and immunity. Further, respiratory function shapes the neuropsychological responses to succumbing to disease, controls the mind-to-body interaction and sets the perception of quality of life. The chapters of this book deal with the preventable drivers of poor respiratory health, the role of health information technology, the improvement in health care delivery and the integration of respiratory health and behavioral health services. Innovative strategies to promote prevention, care coordination and care integration as well as to align disease acceptance and quality of life measures also are tackled. Maintaining respiratory health is of rising research interest as a way of preventing a disease or a non pharmacological therapeutic succor. The book will be of interest to clinicians, family practitioners and medical researchers.
This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.
First edition published in 2002. Second edition published in 2008.
From reviews of the previous edition:'We still have much to learn if disease patterns are to be explained by taking a life course approach... this book provides strong arguments for this approach... the book is a highly qualified starting point for the debate... it will remain a useful summary of pioneer research of huge potential importance for public health.' -Epidemiology'This is not just another epidemiology textbook. It is essential reading for anyone with an active mind who is interested in public health.' -Journal of Public Health Medicine'A truly exciting and extremely informative endeavour for anyone interested in the determinants of human health and disease. This discussion is at the core of current public health issues.' -European Journal of Public Health'The conclusion is of major importance to public health policy. It reinforces the need for a life course strategy, with attention being paid to the mother, baby, child adolescent, and elderly person.' -BMJ'Provokes thought about the origins of chronic diseases, suggests new approaches to identifying particular susceptible individuals and encourages the identification of optimal points in the life course for possible preventive interventions.' -Chronic Diseases in CanadaThe first edition in 1997 of A life course approach to chronic disease epidemiology became a classic text for epidemiological and public health researchers interested in the childhood origins of adult chronic disease. Since then the new field of life course epidemiology has expanded rapidly, attracting the interest not only of academics across the health and social sciences but also policy makers, funding bodies, and the general public. Its purpose is to study how biological and social factors during gestation, childhood, adolescence and earlier adult life independently, cumulatively and interactively influence later life health and disease.Contributors to this fully revised second edition capture the excitement of the developing field and assess the latest evidence regarding sources of risk to health across the life course and across generations. The original chapters on life course influences on cardiovascular disease, diabetes, blood pressure, respiratory disease and cancer have been updated and extended. New chapters on life course influences on obesity, biological ageing and neuropsychiatric disorders have been added. Life course explanations for disease trends and for socioeconomic differentials in disease risk are given more attention in this new edition, reflecting recent developments in the field. The section on policy implications has been expanded, assessing the role of interventions to improve childhood social circumstances, as well as interventions to improve early growth. Emerging new research themes and the theoretical and methodological challenges facing life course epidemiology are highlighted.Readership: Epidemiologists, public health researchers, public health policy makers for developed and developing countries, sociologists and biologists, psychiatrists and social and chronic disease epidemiologists
A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.
Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.
In their later years, Americans of different racial and ethnic backgrounds are not in equally good-or equally poor-health. There is wide variation, but on average older Whites are healthier than older Blacks and tend to outlive them. But Whites tend to be in poorer health than Hispanics and Asian Americans. This volume documents the differentials and considers possible explanations. Selection processes play a role: selective migration, for instance, or selective survival to advanced ages. Health differentials originate early in life, possibly even before birth, and are affected by events and experiences throughout the life course. Differences in socioeconomic status, risk behavior, social relations, and health care all play a role. Separate chapters consider the contribution of such factors and the biopsychosocial mechanisms that link them to health. This volume provides the empirical evidence for the research agenda provided in the separate report of the Panel on Race, Ethnicity, and Health in Later Life.
Genetics and Evolution of Infectious Diseases, Third Edition discusses the evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world where they must confront the dual burden of death and disability due to infectious and chronic illnesses. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases, in recent decades the world has witnessed the emergence of the human immunodeficiency virus (HIV) and the COVID-19 pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. Fully updated and revised, this new edition presents the consequences of such diseases, the evolution of infectious diseases, the genetics of host-pathogen relationship, and the control and prevention strategies that are, or can be, developed. This book offers valuable information to biomedical researchers, clinicians, public health practitioners, decisions-makers, and students and postgraduates studying infectious diseases, microbiology, medicine, and public health that is relevant to the control and prevention of neglected and emerging worldwide diseases. - Takes an integrated approach to infectious diseases - Provides the latest developments in the field of infectious diseases - Focuses on the contribution of evolutionary and genomic studies for the study and control of transmissible diseases - Includes updated and revised contributions from leading authorities, along with six new chapters