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Cancer risk factors include exposure to certain substances, which may contribute to the development of cancer. However, substances can have different levels of cancer-causing potential, and the risk of developing cancer is dependent on several factors, including individual genetic background and the amount and duration of the exposure. This book focuses on various cancer risk factors, covering numerous known, probable, and possible carcinogens; their role in carcinogenesis; mechanisms of carcinogenicity; and methods for detecting carcinogens. And due to the growing concerns over the effects that substances and environmental exposures can have on human health, the chapters also emphasize on the vital need for further topic-related research as well as development and implementation of beneficial approaches.
Chapters on specific metals include physical and chemical properties, methods and problems of analysis, production and uses, environmental levels and exposures, metabolism, levels in tissues and biological fluids, effects and dose-response relationships, carcinogenicity, mutagenicity, teratogenicity and preventative measures, diagnosis, treatment and prognosis.
Plants possess a range of potential cellular mechanisms that may be involved in the detoxification of heavy metals and thus tolerance to metal stress. Metal toxicity causes multiple direct and indirect effects in plants that concern practically all physiological functions. The main purpose of this book is to present comprehensive and concise information on recent advances in the field of metal transport and how genetic diversity affects heavy metal transport in plants. Other key futures of the book are related to metal toxicity and detoxification mechanisms, biochemical tools for HM remediation processes, molecular mechanisms for HM detoxification, how metallomics and metalloproteomics are affected by heavy metal stress in plants, and the role of ROS metabolism in the alleviation of heavy metals. Some chapters also focus on recent developments in the field of phytoremediation. Overall the book presents in-depth information and the most essential advances in the field of heavy metal toxicity in plants in recent years.
This book is the first comprehensive volume on the "Nramp family", highlighting the physiological importance of Nramp proteins as metal transporters. The molecular knowledge of these membrane proteins is presented from an evolutionary perspective, considering Nramp cellular function and mechanism of transport in key model organisms. The pathological significance of Nramp genetic polymorphism is discussed with emphasis on metal homeostasis and microbial infection. The chapters were contributed by leading investigators, providing a timely state of the art book in this rapidly growing field. The Nramp Family will be useful to a broad community of scientists interested in metal transport and molecular biology. It will be of interest to the research audience in the broad fields of metal ions and molecular medicine.
This is the first volume on the role of metal ions in regulating genes to focus not only on toxicity effects of metals but also on the role of metal ions in normal metabolisms, in both prokaryotes and in eukaryotes. This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research.
This volume provides a synthesis of recent work on evolutionary aspects of metal tolerance in plants. It presents contributions from scientists with a wide diversity of expertise. It covers the evolution of heavy metal tolerance in groups of plants, fungi, and protists. The book discusses the physiological, genetic and molecular aspects of metal tolerances. It deals with the evolution of populations in metal-contaminated environments. Several chapters include tolerance in animals in order to place the rest of the book on plants in proper perspective. This publication is an exciting addition for scientists with both applied and basic interest in metal toxicity and tolerance. It is of importance to those in vegetation ecology, land reclamation, agronomy, physiology, population ecology, ecological genetics, evolutionary biology and molecular biology.
Handbook of Bioremediation: Physiological, Molecular and Biotechnological Interventions discusses the mechanisms of responding to inorganic and organic pollutants in the environment using different approaches of phytoremediation and bioremediation. Part One focuses specifically on inorganic pollutants and the use of techniques such as metallothionein-assisted remediation, phytoextraction and genetic manipulation. Part Two covers organic pollutants and consider topics such as plant enzymes, antioxidant defense systems and the remediation mechanisms of different plant species. This comprehensive volume is a must-read for researchers interested in plant science, agriculture, soil science and environmental science. The techniques covered in this book will ensure scientists have the knowledge to practice effective bioremediation techniques themselves. - Provides a comprehensive review of the latest advances in bioremediation of organic and inorganic pollutants - Discusses a range of different phytoremediation techniques - Evaluates the role of genomics and bioinformatics within bioremediation
This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
Each disease-related chapter begins with a detailed description of the patient and the delineating symptoms used for establishing the diagnosis and differential diagnosis. The highly detailed figures illustrate the metabolic derangement in a uniform way, together with essential aspects of the genetics involved, thus affording clarification and better understanding of the treatment. Topics covered range from general aspects such as the clinical approach, emergency treatment, diagnostic procedures, and psychosocial care for the child and the family, to specific discussions of new modes of treatment, including liver, bone marrow transplantation and somatic gene therapy.
Book claims that heavy metal poisoning is the cause of many neurological disorders, and is passed on from one generation to the next through epigenetics.