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Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and Their Interaction covers the special heritability characteristics and identifying genetic and environmental contributions to cardiovascular health. This important reference provides an overview of the genetic basis of cardiovascular disease and its risk factors. Included are important topics, ranging from lifestyle choices, risk factors, and exposure, to pollutants and chemicals. Also covered are the influences of Mendelian traits and familial aggregation and the interactions and interrelationships between genetics and environmental factors which, when compared, provide a sound understanding of the interplay between inherited and acquired risk factors. The book provides a much needed reference for this rapidly growing field of study. By combining the latest research within the structured chapters of this reference, a better understanding of genetic and environmental contribution to cardiovascular disease is found, helping to substantiate further investigations in the field and design prevention and treatment strategies. - Provides an overview of the genetic basis of cardiovascular disease and its risk factors - Reviews several large population-based studies which indicate that exposure to several environmental factors may increase CVD morbidity and mortality, exploring the plausibility of this association by data from animal studies - Reflects on future studies to help understanding the role of genes and environmental factors in the development and progression of cardiovascular disease
Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included. This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as: Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?
In this book/CD-ROM package, Raizada (physiology and functional genomics, University of Florida) brings together scientists and clinicians from around the world to explore recent molecular approaches to understanding the cardiovascular system in health and disease. Contributors cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension, and describe methods for identifying the genes that cause susceptibility to cardiovascular diseases. The CD-ROM contains an electronic version of the book that can be used on a PC or PDA. The audience for the book includes cardiovascular researchers, clinical fellows, and pharmacologists. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).
Classic and modern tools of genetics have been applied to hypertension research for some 20 years. This volume in the Handbook of Hypertension series aims to go beyond a simple summary of discoveries and provides a critical commentary on many controversial issues. It will be particularly useful for clinician scientists at all stages of their careers, graduate students and post-doctoral scientists as well as all those interested in cardiovascular medicine and research throughout the entire spectrum from bench to bedside. As in every relatively young area of research, the initial excitement over the early positive observations has not always been confirmed by subsequent larger studies with greater statistical power. Issues related to current recommendations on design of studies and their analysis are therefore included. Pharmacogenetics and pharmacogenomics have been the subjects of many debates in recent years and are of particular importance in hypertension as life-long treatments, frequently with multiple drugs are given to millions of people world-wide. A critical appraisal of this controversial topic is provided. Several chapters on experimental genetics of hypertension with a special focus on physiological genomics are also included.
This textbook is a readily accessible educational tool for all fellows undertaking subspecialty training in interventional cardiology, while also serving as a refresher to early career interventional cardiologists. The key objective is to equip the reader with an evidence-based expert-led resource focussed primarily on pre-procedural planning, peri-procedural decision-making, and the salient technical aspects of performing safe and effective coronary intervention, the intention being to support the therapeutic decision-making process in the emergency room, coronary care unit or cath lab in order to optimize patient outcome. The Interventional Cardiology Training Manual provides readers with a step-by-step guide to the basic principles underpinning coronary intervention and facilitates rapid access to best practice from the experts, presented in a pragmatic, digestible and concise format. Uniquely, each chapter has been written in a heart center-specific manner, affording the reader an opportunity to learn how individual institutions perform a specific procedure, which algorithms and guidelines they follow and what evidence they draw on to instigate the best possible care for their patients.
Promoting developments in the diagnosis, prevention, and treatment of coronary artery disease, this reference furnishes the latest information on new and emerging risk factors for atherothrombotic vascular disorders-analyzing lipid-related and psychosocial risk factors, the genetic aspects of disease, the potential role of infection and inflammatio
This volume of the esteemed Progress in Molecular Biology and Translational Science series focuses on cutting-edge research related to the genetics of cardiovascular disease. Written by top experts in the field, this volume covers a range of topics, including: Genetic models of atherosclerosis MicroRNAs in cardiovascular disease The role of the transcription factor KLF2 in vascular development and disease Zebrafish as models of cardiovascular disease and hematopoietic development Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.
Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyfold increased in first degree relatives of persons with an early onset of the disease. Such studies provide compelling evidence of the high degree of heritability of CHD and its risk factors. This book consolidates the available evidence for the roles of genetics in atherosclerosis, its correlates and its sequelae. It presents and discusses the methodology currently used to elucidate the role of genetics. Separate parts focus on evidence of familial aggregation and ethnic variability of the disease and on monogenic and polygenic inheritance modes including all the recent findings and innovation. The book also contains chapters on the genetic aspects of vessel wall processes, such as early structural findings in histological studies and the variability of coronary anatomic patterns. Polymorphisms at the DNA level (RFLP) are detailed and reviewed. Directions for future research in the exciting and fast developing realm of genetic epidemiology are outlined and the major preventive and public health implications are discussed. Genetic Factors in Coronary Heart Disease provides a systematic review of findings, integrated to offer a comprehensive summary and stepping stone for future research. It will be of interest to investigators in atherosclerosis, genetics, epidemiology, biostatistics, cardiology and public health.