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**Selected for Doody's Core Titles® 2024 in Dentistry** Comprehensive, cutting-edge content addresses contemporary orthodontic practice! Orthodontics: Current Principles and Techniques, 7th Edition provides an evidence-based approach to orthodontic diagnosis, treatment planning, and clinical techniques, including esthetics, genetics, temporary anchorage devices, aligners, technology-assisted biomechanics, and much more. New to this edition are seven chapters, covering topics like AI, maxillary expansion in adults, Class II correctors, and autotransplantation. Newly authored chapters on orthognathic surgery and the craniofacial team, the periodontal-orthodontic interface, interdisciplinary treatment, and accelerated tooth movement, among others, address current perspectives. The 7th edition comes with access to an enhanced eBook version, which includes videos and additional visuals to show concepts difficult to explain with words alone. Readers can also find additional, online-only chapters and a fully searchable version of the text. Respected editors Lee Graber, Katherine Vig, and Greg Huang are joined by new editor Pádhraig Fleming, along with expert contributors from around the world. This text provides the most current and comprehensive collection of orthodontic knowledge, making it the go-to book for orthodontic residents and practitioners! - Comprehensive coverage provides a one-stop resource for the field of orthodontics, including foundational theory and the latest on the materials and techniques used in today's practice. - Experienced, renowned editors lead a team of expert, international contributors to provide the most authoritative clinical practice and supporting science from the best and brightest in the industry. - More than 3,400 images include a mixture of radiographs, full-color clinical photos, and anatomic or schematic line drawings, showing examples of treatment, techniques, and outcomes. - Detailed, illustrated case studies show the decision-making process, highlighting the consequences of various treatment techniques over time. - Extensive references make it easy to look up the latest in orthodontic research and evidence-based information, and all references also appear online. - Enhanced ebook, included with every print purchase, features a fully searchable version of the text and bonus online-only chapters, instructional videos, and more. - NEW! Seven chapters cover topics such as AI, maxillary expansion in adults, Class II correctors, and autotransplantation. Newly authored chapters on aligners, orthognathic surgery, the periodontal-orthodontic interface, interdisciplinary and computer-assisted treatment, temporary anchorage devices, and accelerated tooth movement, among others, address current perspectives. - UPDATED! Relevant literature and evidence-based practices are featured throughout the text. - NEW! Additional photos and illustrations visually reinforce key concepts and procedures.
Monthly, with annual cumulations. Comprehensive, current index to periodical medical literature intended for use of practitioners, investigators, and other workers in community medicine who are concerned with the etiology, prevention, and control of disease. Citations are derived from MEDLARS tapes for Index medicus of corresponding date. Arrangement by 2 sections, i.e., Selected subject headings, and Diseases, organisms, vaccines. No author index.
Temporomandibular disorders (TMDs), are a set of more than 30 health disorders associated with both the temporomandibular joints and the muscles and tissues of the jaw. TMDs have a range of causes and often co-occur with a number of overlapping medical conditions, including headaches, fibromyalgia, back pain and irritable bowel syndrome. TMDs can be transient or long-lasting and may be associated with problems that range from an occasional click of the jaw to severe chronic pain involving the entire orofacial region. Everyday activities, including eating and talking, are often difficult for people with TMDs, and many of them suffer with severe chronic pain due to this condition. Common social activities that most people take for granted, such as smiling, laughing, and kissing, can become unbearable. This dysfunction and pain, and its associated suffering, take a terrible toll on affected individuals, their families, and their friends. Individuals with TMDs often feel stigmatized and invalidated in their experiences by their family, friends, and, often, the health care community. Misjudgments and a failure to understand the nature and depths of TMDs can have severe consequences - more pain and more suffering - for individuals, their families and our society. Temporomandibular Disorders: Priorities for Research and Care calls on a number of stakeholders - across medicine, dentistry, and other fields - to improve the health and well-being of individuals with a TMD. This report addresses the current state of knowledge regarding TMD research, education and training, safety and efficacy of clinical treatments of TMDs, and burden and costs associated with TMDs. The recommendations of Temporomandibular Disorders focus on the actions that many organizations and agencies should take to improve TMD research and care and improve the overall health and well-being of individuals with a TMD.
Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases. As a prototype antioxidant, it has been involved in cell protection from the noxious effect of excess oxidant stress, both directly and as a cofactor of glutathione peroxidases. In addition, it has long been known that GSH is capable of forming disulfide bonds with cysteine residues of proteins, and the relevance of this mechanism ("S-glutathionylation") in regulation of protein function has been well documented in a number of research fields. Rather paradoxically, it has also been highlighted that GSH—and notably its catabolites, as originated by metabolism by gamma-glutamyltransferase—can promote oxidative processes, by participating in metal ion-mediated reactions eventually leading to formation of reactive oxygen species and free radicals. Also, a fundamental role of GSH has been recognized in the storage and transport of nitric oxide (NO), in the form of S-nitrosoglutathione (GSNO). The significance of GSH as a major factor in regulation of cell life, proliferation, and death, can be regarded as the integrated result of all these roles, as well as of more which are emerging in diverse fields of biology and pathophysiology. Against this background, modulation of GSH levels and GSH-related enzyme activities represents a fertile field for experimental pharmacology in numerous and diverse perspectives of animal, plant and microbiologic research. This research topic includes 14 articles, i.e. 4 Opinion Articles, 6 Reviews, and 4 Original Research Articles. The contributions by several distinguished research groups, each from his own standpoint of competence and expertise, provide a comprehensive and updated view over the diverse roles, the changing faces of GSH and GSH-related enzymes in cell’s health, disease and death.
Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics. Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. - Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potential - Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysis - Includes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.