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- For the first time, Nobel Prize winner, Edward B. Lewis' research papers are published within one volume - Papers are organized into sections that reflect the focus of the research - Commentaries by Howard Lipshitz highlight key methods and results by explaining the science so it is accessible to upper-level undergraduates, graduate students, and professional researchers
The Evolution of Differentiation attempts to sketch the outlines of a framework from what is now known or suspected of the various aspects of differentiation in all types of organisms. This book surveys the many aspects of differentiation that are seen today, and in particular, because of the evident universality of expression of the genetic code, to enquire whether any similar universality exists in the methods of gene repression and activation. The information reviewed ranges from the chemical control of the genetic mechanisms of unicellular organisms during their various phases of activity, to the chemical control of differentiation in multicellular organisms both during embryonic development and in the adult state. Finally, some consideration is also given to that collapse of differentiation which leads to cancer.
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science