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The authors' aim with this handbook, is to provide a rapid ready-reference to help in the often complex task of handling, using and disposing of chemicals safely and with minimum risk to people's health or damage to facilities or to the environment. The book provides look-up data, and concise, clear explanations of general chemical principles, physiochemical and reactive properties, toxicities and exposure limits, flammability characteristics, monitoring techniques, personal protection and other parameters and requirements relating to compliance with designated safe practice, control of risks to people's health and limitation of environmental impact. - Over 600 pages of valuable reference materialIncludes information on physiochemical and reactive properties, toxicities and exposure limits, flammability characteristics, monitoring techniques, personal protection and other parameters and requirements relating to complianceSummarizes core information for quick reference in the workplace or in transit
Terpenoids play an important part in all our lives, from Vitamin A and hormones to perfumes and pharmaceuticals. This book provides an introduction to terpenoid chemistry, concentrating on the lower terpenoids, but the basic principles taught are also the foundation for the chemistry of the higher terpenoids. Coverage includes: the biogenesis of terpenoids; some of the history of the field; the principles of structural determination; and the importance of stereochemistry and stereoselective synthesis. Carbocation chemistry is introduced, as are the principles of total and partial synthesis. Finally, industrial chemistry (both discovery chemistry and chemical process development) is discussed, using the volatile terpenoids of perfumery to illustrate basic concepts. Ideal as both an introduction to terpenoid chemistry and as a refresher course, A Fragrant Introduction to Terpenoid Chemistry, with its real-life problems and appreciation of the relevance of chemistry to everyday life, will prove invaluable to students, lecturers and industrialists alike.
AEROSOL SCIENCE TECHNOLOGY AND APPLICATIONS Aerosols influence many areas of our daily life. They are at the core of environmental problems such as global warming, photochemical smog and poor air quality. They can also have diverse effects on human health, where exposure occurs in both outdoor and indoor environments. However, aerosols can have beneficial effects too; the delivery of drugs to the lungs, the delivery of fuels for combustion and the production of nanomaterials all rely on aerosols. Advances in particle measurement technologies have made it possible to take advantage of rapid changes in both particle size and concentration. Likewise, aerosols can now be produced in a controlled fashion. Reviewing many technological applications together with the current scientific status of aerosol modelling and measurements, this book includes: Satellite aerosol remote sensing The effects of aerosols on climate change Air pollution and health Pharmaceutical aerosols and pulmonary drug delivery Bioaerosols and hospital infections Particle emissions from vehicles The safety of emerging nanomaterials Radioactive aerosols: tracers of atmospheric processes With the importance of this topic brought to the public's attention after the eruption of the Icelandic volcano Eyjafjallajökull, this book provides a timely, concise and accessible overview of the many facets of aerosol science.
Teaches students the basic techniques and equipment of the organic chemistry lab — the updated new edition of the popular hands-on guide. The Organic Chem Lab Survival Manual helps students understand the basic techniques, essential safety protocols, and the standard instrumentation necessary for success in the laboratory. Author James W. Zubrick has been assisting students navigate organic chemistry labs for more than three decades, explaining how to set up the laboratory, make accurate measurements, and perform safe and meaningful experiments. This practical guide covers every essential area of lab knowledge, from keeping detailed notes and interpreting handbooks to using equipment for chromatography and infrared spectroscopy. Now in its eleventh edition, this guide has been thoroughly updated to cover current laboratory practices, instruments, and techniques. Focusing primarily on macroscale equipment and experiments, chapters cover microscale jointware, drying agents, recrystallization, distillation, nuclear magnetic resonance, and much more. This popular textbook: Familiarizes students with common lab instruments Provides guidance on basic lab skills and procedures Includes easy-to-follow diagrams and illustrations of lab experiments Features practical exercises and activities at the end of each chapter Provides real-world examples of lab notes and instrument manuals The Organic Chem Lab Survival Manual: A Student’s Guide to Techniques, 11th Edition is an essential resource for students new to the laboratory environment, as well as those more experienced seeking to refresh their knowledge.
A reference for investigators in pulmonary toxicology and immunotoxicology and for people involved in administrating and regulating matters related to inhale materials, and serviceable as a textbook for a graduate or advanced undergraduate course in pulmonary immunotoxicology. US researchers from academic and industrial laboratories provide information concerning the effects of various inhaled materials on the immune system of the respiratory tract. They cover basic background concepts including the normal structure and function of the respiratory system and its basic immunology, the major types of pathological consequences that can arise from immunomodulation within the respiratory tract, the specific major classes of airborne agents that are known to alter immune function, and risk assessment. Annotation copyrighted by Book News, Inc., Portland, OR
Describes a six-stage process which can be adopted by organisations wishing to implement a programme of performance monitoring for process safety risks.
Decision making is a complex phenomenon which normally is deeply integrated into social life. At the same time the decision making process often gives the decision maker an opportunity for conscious planning and for taking a reflective stance with respect to the action considered. This suggests that decision making allows creative solutions with a potential to change the course of events both on an individual and a collective level. Given these considerations, we argue that in order to more fully understand decision making the perspectives of different disciplines are needed. In this volume we have attempted to draw together contributions that would provide a broad view of decision making. Much work has been carried out in the writing and editing of this volume. First of all we would like to thank the contributors for their efforts in producing interesting and important texts and for their patience in the editorial process. Each chapter was edited by two or three reviewers. These reviewers are listed on a separate page in this book. Our heartfelt thanks go to them for their time and for their incisive and constructive reviews! We are also grateful to the publishing editors at Kluwer Academic Publishers, Christiane Roll and Dorien Francissen, who have been generous with their encouragement and patience throughout the editorial process.
A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
This revised edition of a best-selling book continues to provide a basis for the identification and evaluation of chemical reaction hazards for chemists, engineers, plant personnel, and students. Before undertaking the design of a chemical manufacturing process it is vital that the chemical reactions involved be fully understood, potential hazards assessed, and safety measures planned. Chemical Reaction Hazards aims to help the people responsible for this design and operation to meet the general duties of safety. Two major additions to this revised book are the appendices. One of these describes 100 incidents, illustrating their cause and indicating consequences if appropriate procedures within this guide are not followed. The second provides a practical example of a typical chemical reaction hazard assessment, from consideration of the process description, through experimental testing to the specification of safety measures.