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Editor Joseph P. Byrne, together with an advisory board of specialists and over 100 scholars, research scientists, and medical practitioners from 13 countries, has produced a uniquely interdisciplinary treatment of the ways in which diseases pestilence, and plagues have affected human life. From the Athenian flu pandemic to the Black Death to AIDS, this extensive two-volume set offers a sociocultural, historical, and medical look at infectious diseases and their place in human history from Neolithic times to the present. Nearly 300 entries cover individual diseases (such as HIV/AIDS, malaria, Ebola, and SARS); major epidemics (such as the Black Death, 16th-century syphilis, cholera in the nineteenth century, and the Spanish Flu of 1918-19); environmental factors (such as ecology, travel, poverty, wealth, slavery, and war); and historical and cultural effects of disease (such as the relationship of Romanticism to Tuberculosis, the closing of London theaters during plague epidemics, and the effect of venereal disease on social reform). Primary source sidebars, over 70 illustrations, a glossary, and an extensive print and nonprint bibliography round out the work.
"Much research has been conducted to provide researchers and hearing healthcare professionals with updated information in regard to hearing assessments, results interpretation and case management. This ongoing research is particularly imperative to guide clinicians with optimized methods in assessing and managing pediatric patients with hearing impairment and disability. As such, tremendous research efforts have been made in determining the most optimum methods in assessing hearing using both subjective and objective tests. Since hearing loss can occur due to disrupted peripheral and/or central auditory pathway, there is also a growing interest to study children with auditory processing disorder (APD). Even though notable achievements have been observed in understanding APD, more research is required, particularly in establishing a gold standard APD test and its specific interventions. Aditionally, having an objective test such as speech-evoked auditory brainstem response is beneficial to understand how speech sounds are encoded within the brainstem region in hearing-impaired children, as well as in those with compromised neural function. In this book, we have gathered research from Malaysia and India in this field and hope it will be of interest to our readers"--
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.