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A thorough introduction to the basics of bioengineering, with a focus on applications in the emerging "white" biotechnology industry. As such, this latest volume in the "Advanced Biotechnology" series covers the principles for the design and analysis of industrial bioprocesses as well as the design of bioremediation systems, and several biomedical applications. No fewer than seven chapters introduce stoichiometry, kinetics, thermodynamics and the design of ideal and real bioreactors, illustrated by more than 50 practical examples. Further chapters deal with the tools that enable an understanding of the behavior of cell cultures and enzymatically catalyzed reactions, while others discuss the analysis of cultures at the level of the cell, as well as structural frameworks for the successful scale-up of bioreactions. In addition, a short survey of downstream processing options and the control of bioreactions is given. With contributions from leading experts in industry and academia, this is a comprehensive source of information peer-reviewed by experts in the field.
A thorough introduction to the basics of bioengineering, with a focus on applications in the emerging "white" biotechnology industry. As such, this latest volume in the "Advanced Biotechnology" series covers the principles for the design and analysis of industrial bioprocesses as well as the design of bioremediation systems, and several biomedical applications. No fewer than seven chapters introduce stoichiometry, kinetics, thermodynamics and the design of ideal and real bioreactors, illustrated by more than 50 practical examples. Further chapters deal with the tools that enable an understanding of the behavior of cell cultures and enzymatically catalyzed reactions, while others discuss the analysis of cultures at the level of the cell, as well as structural frameworks for the successful scale-up of bioreactions. In addition, a short survey of downstream processing options and the control of bioreactions is given. With contributions from leading experts in industry and academia, this is a comprehensive source of information peer-reviewed by experts in the field.
A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.
For sophomore-level courses in Bioengineering, Biomedical Engineering, and related fields. A unifying, interdisciplinary approach to the fundamentals of bioengineering Now in its 2nd Edition, Bioengineering Fundamentals combines engineering principles with technical rigor and a problem-solving focus, ultimately taking a unifying, interdisciplinary approach to the conservation laws that form the foundation of bioengineering: mass, energy, charge, and momentum. The text emphasizes fundamental concepts, practical skill development, and problem-solving strategies while incorporating a wide array of examples and case studies. This 2nd Edition has been updated and expanded with new and clarified content, plus new homework and example problems.
Under the direction of John Enderle, Susan Blanchard and Joe Bronzino, leaders in the field have contributed chapters on the most relevant subjects for biomedical engineering students. These chapters coincide with courses offered in all biomedical engineering programs so that it can be used at different levels for a variety of courses of this evolving field. Introduction to Biomedical Engineering, Second Edition provides a historical perspective of the major developments in the biomedical field. Also contained within are the fundamental principles underlying biomedical engineering design, analysis, and modeling procedures. The numerous examples, drill problems and exercises are used to reinforce concepts and develop problem-solving skills making this book an invaluable tool for all biomedical students and engineers. New to this edition: Computational Biology, Medical Imaging, Genomics and Bioinformatics.* 60% update from first edition to reflect the developing field of biomedical engineering* New chapters on Computational Biology, Medical Imaging, Genomics, and Bioinformatics* Companion site: http://intro-bme-book.bme.uconn.edu/* MATLAB and SIMULINK software used throughout to model and simulate dynamic systems* Numerous self-study homework problems and thorough cross-referencing for easy use
Fully updated fundamental biomedical engineering principles and technologies This state-of-the-art resource offers unsurpassed coverage of fundamental concepts that enable advances in the field of biomedical engineering. Biomedical Engineering Fundamentals, Third Edition, contains all the information you need to improve efficacy and efficiency in problem solving, no matter how simple or complex the problem. Thoroughly revised by experts across the biomedical engineering discipline, this hands-on guide provides the foundational knowledge required for the development of innovative devices, techniques, and treatments. Coverage includes: Modeling of biomedical systems and heat transfer applications Physical and flow properties of blood Respiratory mechanics and gas exchange Respiratory muscles, human movement, and the musculoskeletal system Electromyography and muscle forces Biopolymers, biomedical composites, and bioceramics Cardiovascular, dental, and orthopedic biomaterials Tissue regeneration and regenerative medicine Bioelectricity, biomedical signal analysis, and biosensors Neural engineering and electrical stimulation of nervous systems Causes of medical device failure and FDA requirements Cardiovascular, respiratory, and artificial kidney devices Infrared and ultrasound imaging, MRIs, and nuclear medicine Imaging, laser Doppler, and fetal and optical monitoring Computer-integrated surgery and medical robotics Intelligent assistive technology and rehabilitators Artificial limbs, hip and knee replacement, and sensory augmentation Healthcare systems engineering and medical informatics Hospital information systems and computer-based patient records Sterile medical device package development
This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.
This unique book about bioscience and the bioengineering of titanium materials is based on more than 1,000 published articles. It bridges the gap between the medical/dental fields and the engineering/technology areas, due to the author's unique experience in both during the last 30 years. The book covers Materials Classifications, Chemical and Electrochemical Reactions, Oxidation, Biological Reactions, Implant-related Biological Reactions, Applications, Fabri-cation Technologies, Surface Modifications, and Future Perspectives.* Provides quick access to the primary literature in this field* Reviews studies of titanium materials in medical and dental applications, as reported in nearly 1,500 articles published over last several years* Draws information from several types of studies and reports* Helps readers answer questions about the most appropriate materials and when to use them
Combining materials science, mechanics, implant design and clinical applications, this self-contained text provides a complete grounding to the field.