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This edition draws on data from the ethology of defense learning theory, anxiety disorders, the psychopharmacology of anti-anxiety drugs and amnesia to present a theory of anxiety and the brain systems, especially the septo-hippocampal system that subserve it.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
The Origins and History of Consciousness draws on a full range of world mythology to show how individual consciousness undergoes the same archetypal stages of development as human consciousness as a whole. Erich Neumann was one of C. G. Jung's most creative students and a renowned practitioner of analytical psychology in his own right. In this influential book, Neumann shows how the stages begin and end with the symbol of the Uroboros, the tail-eating serpent. The intermediate stages are projected in the universal myths of the World Creation, Great Mother, Separation of the World Parents, Birth of the Hero, Slaying of the Dragon, Rescue of the Captive, and Transformation and Deification of the Hero. Throughout the sequence, the Hero is the evolving ego consciousness. Featuring a foreword by Jung, this Princeton Classics edition introduces a new generation of readers to this eloquent and enduring work.
Edited by high caliber experts, and contributed to by quality researchers and practitioners in psychology and related fields. Includes over 500 topical entries Each entry features suggested readings and extensive cross-referencing Accessible to students and general readers Edited by two outstanding scholars and clinicians
The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.
The CA3 hippocampal region receives information from the entorhinal cortex either directly from the perforant path or indirectly from the dentate gyrus via the mossy fibers (MFs). According to their specific targets (principal/mossy cells or interneurons), MFs terminate with large boutons or small filopodial extensions, respectively. MF-CA3 synapses are characterized by a low probability of release and pronounced frequency-dependent facilitation. In addition MF terminals are endowed with mGluRs that regulate their own release. We will describe the intrinsic membrane properties of pyramidal cells, which can sometimes fire in bursts, together with the geometry of their dendritic arborization. The single layer of pyramidal cells is quite distinct from the six-layered neocortical arrangement. The resulting aligned dendrites provides the substrate for laminated excitatory inputs. They also underlie a precise, diversity of inhibitory control which we will also describe in detail. The CA3 region has an especially rich internal connectivity, with recurrent excitatory and inhibitory loops. In recent years both in vivo and in vitro studies have allowed to better understand functional properties of the CA3 auto-associative network and its role in information processing. This circuit is implicated in encoding spatial representations and episodic memories. It generates physiological population synchronies, including gamma, theta and sharp-waves that are presumed to associate firing in selected assemblies of cells in different behavioral conditions. The CA3 region is susceptible to neurodegeneration during aging and after stresses such as infection or injury. Loss of some CA3 neurones has striking effects on mossy fiber inputs and can facilitate the generation of pathologic synchrony within the CA3 micro-circuit. The aim of this special topic is to bring together experts on the cellular and molecular mechanisms regulating the wiring properties of the CA3 hippocampal microcircuit in both physiological and pathological conditions, synaptic plasticity, behavior and cognition.We will particularly emphasize the dual glutamatergic and GABAergic phenotype of MF-CA3 synapses at early developmental stages and the steps that regulate the integration of newly generated neurons into the adult dentate gyrus-CA3 circuit.
This is the first book to provide an overview of current research using cutting-edge genetic and neuroimaging methods in the study of personality. Integrating compelling lines of inquiry that until now have largely remained disparate, the volume brings together leading investigators from personality psychology; clinical psychology and psychiatry; cognitive, affective, and behavioral neuroscience; and comparative psychology. Coverage includes the structure of personality and its mapping onto biology, genetic markers for individual differences and vulnerability towards psychopathology, sex differences and age-related processes, and functional neuroimaging approaches.
Some investigators have argued that emotions, especially animal emotions, are illusory concepts outside the realm of scientific inquiry. However, with advances in neurobiology and neuroscience, researchers are demonstrating that this position is wrong as they move closer to a lasting understanding of the biology and psychology of emotion. In Affective Neuroscience, Jaak Panksepp provides the most up-to-date information about the brain-operating systems that organize the fundamental emotional tendencies of all mammals. Presenting complex material in a readable manner, the book offers a comprehensive summary of the fundamental neural sources of human and animal feelings, as well as a conceptual framework for studying emotional systems of the brain. Panksepp approaches emotions from the perspective of basic emotion theory but does not fail to address the complex issues raised by constructionist approaches. These issues include relations to human consciousness and the psychiatric implications of this knowledge. The book includes chapters on sleep and arousal, pleasure and fear systems, the sources of rage and anger, and the neural control of sexuality, as well as the more subtle emotions related to maternal care, social loss, and playfulness. Representing a synthetic integration of vast amounts of neurobehavioral knowledge, including relevant neuroanatomy, neurophysiology, and neurochemistry, this book will be one of the most important contributions to understanding the biology of emotions since Darwins The Expression of the Emotions in Man and Animals
We frequently hear that we live in an age of anxiety, from 'therapy culture', the Atkins diet and child anti-depressants to gun culture and weapons of mass destruction. While Hollywood regularly cashes in on teenage anxiety through its Scream franchise, pharmaceutical companies churn out new drugs such as Paxil to combat newly diagnosed anxieties. On Anxiety takes a fascinating, psychological plunge behind the scenes of our panic stricken culture and into anxious minds, asking who and what is responsible. Putting anxiety on the couch, Renata Salecl asks some much-needed questions: Is anxiety about the absence of authority or too much of it? Do the media report anxiety or create it? Are drugs a cure for anxiety or its cause? Is anxiety about being yourself or someone else, and is anxiety really the ultimate obstacle to happiness? Drawing on vivid examples from films such as the X Files and Cyrano de Bergerac, drugs used on soldiers to combat anxiety, the anxieties of love and motherhood, and fake Holocaust memoirs, Renata Salecl argues that what really produces anxiety is the attempt to get rid of it. Erudite and compelling, On Anxiety is essential reading for anyone interested in philosophy, psychology and the cultural phenomenon of anxiety today.
The Neuropsychology of Anxiety first appeared in 1982, quickly establishing itself as a classic work in the psychology and neuroscience literature. It presented an innovative, and at times controversial, theory of anxiety and the brain systems, especially the septo-hippocampal system, that subserve it. It rapidly established itself as an important new work in the field. This Second Edition is a significant departure from the first, drawing upon extensive reviews of data from the ethology of defence, learning theory, the psychopharmacology of anti-anxiety drugs, anxiety disorders, and clinical and laboratory analysis of amnesia. The cognitive and behavioural functions in anxiety of the septo-hippocampal system and the amygdala are extensively analysed, as are their separate roles in memory and fear. Their functions are related to a hierarchy of additional structures that control other forms of defensive behaviour. The resulting theory is applied to the typology, symptoms, and therapy of anxiety and phobic disorders, and to the symptoms of amnesia. Available for the first time in paperback, this new edition will be a valuable reference text for researchers and graduate students in psychology, clinical psychology, psychiatry, psychopharmacology, neuroscience, and neurology.