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Artificial neural networks have been recognized as a powerful tool to learn and reproduce systems in various fields of applications. Neural net works are inspired by the brain behavior and consist of one or several layers of neurons, or computing units, connected by links. Each artificial neuron receives an input value from the input layer or the neurons in the previ ous layer. Then it computes a scalar output from a linear combination of the received inputs using a given scalar function (the activation function), which is assumed the same for all neurons. One of the main properties of neural networks is their ability to learn from data. There are two types of learning: structural and parametric. Structural learning consists of learning the topology of the network, that is, the number of layers, the number of neurons in each layer, and what neurons are connected. This process is done by trial and error until a good fit to the data is obtained. Parametric learning consists of learning the weight values for a given topology of the network. Since the neural functions are given, this learning process is achieved by estimating the connection weights based on the given information. To this aim, an error function is minimized using several well known learning methods, such as the backpropagation algorithm. Unfortunately, for these methods: (a) The function resulting from the learning process has no physical or engineering interpretation. Thus, neural networks are seen as black boxes.
This book presents a range of current research topics in biological network modeling, as well as its application in studies on human hosts, pathogens, and diseases. Systems biology is a rapidly expanding field that involves the study of biological systems through the mathematical modeling and analysis of large volumes of biological data. Gathering contributions from renowned experts in the field, some of the topics discussed in depth here include networks in systems biology, the computational modeling of multidrug-resistant bacteria, and systems biology of cancer. Given its scope, the book is intended for researchers, advanced students, and practitioners of systems biology. The chapters are research-oriented, and present some of the latest findings on their respective topics.
Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: - How the brain carries out important tasks via networks - How these networks interact in normal brain function - Major mechanisms that control network function - The interaction of the normal networks to produce more complex behaviors - How brain disorders can result from abnormal interactions - How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. - Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant - Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders - Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain - Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization. - Winner of the 2017 PROSE Award in Biomedicine & Neuroscience and the 2017 British Medical Association (BMA) Award in Neurology - Extensively illustrated throughout by graphical representations of key mathematical concepts and their practical applications to analyses of nervous systems - Comprehensively covers graph theoretical analyses of structural and functional brain networks, from microscopic to macroscopic scales, using examples based on a wide variety of experimental methods in neuroscience - Designed to inform and empower scientists at all levels of experience, and from any specialist background, wanting to use modern methods of network science to understand the organization of the brain
Biologically inspiredcomputing isdi?erentfromconventionalcomputing.Ithas adi?erentfeel; often the terminology does notsound like it’stalkingabout machines.The activities ofthiscomputingsoundmorehumanthanmechanistic as peoplespeak ofmachines that behave, react, self-organize,learn, generalize, remember andeven to forget.Much ofthistechnology tries to mimic nature’s approach in orderto mimicsome of nature’s capabilities.They havearigorous, mathematical basisand neuralnetworks forexamplehaveastatistically valid set on which the network istrained. Twooutlinesaresuggestedasthepossibletracksforpatternrecognition.They are neuralnetworks andfunctionalnetworks.NeuralNetworks (many interc- nected elements operating in parallel) carryout tasks that are not only beyond the scope ofconventionalprocessing but also cannotbeunderstood in the same terms.Imagingapplicationsfor neuralnetworksseemtobea natural?t.Neural networks loveto do pattern recognition. A new approachto pattern recognition usingmicroARTMAP together with wavelet transforms in the context ofhand written characters,gestures andsignatures havebeen dealt.The KohonenN- work,Back Propagation Networks andCompetitive Hop?eld NeuralNetwork havebeen considered for various applications. Functionalnetworks,beingageneralizedformofNeuralNetworkswherefu- tionsarelearnedratherthanweightsiscomparedwithMultipleRegressionAn- ysisforsome applicationsandtheresults are seen to be coincident. New kinds of intelligence can be added to machines, and we will havethe possibilityof learningmore about learning.Thus our imaginationsand options are beingstretched.These new machines will be fault-tolerant,intelligentand self-programmingthustryingtomakethemachinessmarter.Soastomakethose who use the techniques even smarter. Chapter1 isabrief introduction toNeural and Functionalnetworks in the context of Patternrecognitionusing these disciplinesChapter2 givesa review ofthearchitectures relevantto the investigation andthedevelopment ofthese technologies in the past few decades. Retracted VIII Preface Chapter3begins with the lookattherecognition ofhandwritten alphabets usingthealgorithm for ordered list ofboundary pixelsas well as the Ko- nenSelf-Organizing Map (SOM).Chapter 4 describes the architecture ofthe MicroARTMAP and its capability.
The present book illustrates the theoretical aspects of several methodologies related to the possibility of i) enhancing the poor spatial information of the electroencephalographic (EEG) activity on the scalp and giving a measure of the electrical activity on the cortical surface. ii) estimating the directional influences between any given pair of channels in a multivariate dataset. iii) modeling the brain networks as graphs. The possible applications are discussed in three different experimental designs regarding i) the study of pathological conditions during a motor task, ii) the study of memory processes during a cognitive task iii) the study of the instantaneous dynamics throughout the evolution of a motor task in physiological conditions. The main outcome from all those studies indicates clearly that the performance of cognitive and motor tasks as well as the presence of neural diseases can affect the brain network topology. This evidence gives the power of reflecting cerebral "states" or "traits" to the mathematical indexes derived from the graph theory. In particular, the observed structural changes could critically depend on patterns of synchronization and desynchronization - i.e. the dynamic binding of neural assemblies - as also suggested by a wide range of previous electrophysiological studies. Moreover, the fact that these patterns occur at multiple frequencies support the evidence that brain functional networks contain multiple frequency channels along which information is transmitted. The graph theoretical approach represents an effective means to evaluate the functional connectivity patterns obtained from scalp EEG signals. The possibility to describe the complex brain networks sub-serving different functions in humans by means of "numbers" is a promising tool toward the generation of a better understanding of the brain functions. Table of Contents: Introduction / Brain Functional Connectivity / Graph Theory / High-Resolution EEG / Cortical Networks in Spinal Cord Injured Patients / Cortical Networks During a Lifelike Memory Task / Application to Time-varying Cortical Networks / Conclusions
Functional MRI: Basic Principles and Emerging Clinical Applications provides an overview of the basic principles of fMRI for clinicians with minimal knowledge of the imaging technique and its research potential and clinical applications. The text is divided into two parts, with Section I covering the primary signal measured in fMRI (BOLD), the correlation between neuronal activity and the BOLD signal, and how the data is analyzed and interpreted in fMRI. Section II explores applications of fMRI in cognitive neuroscience and common psychiatric disorders, surgical planning in neurosurgery, anesthesia and the intensive care unit, and more. Timely and highly accessible, this book is a valuable resource for researchers and clinicians interested in understanding what fMRI is, how it works, and its applications.
Throughout the history of neuroscience, technological advances are the drivers behind many major advances in our understanding of the nervous system. Investigations of the structure and function of the brain take place on multiple scales, including macroscale at the level of brain regions, mesoscale at the level of neuronal populations, and microscale at the level of single neurons and neuron to neuron interactions. Integration of knowledge over these scales requires novel techniques and interpretations. In this research topic, we highlight nine articles that integrate structural and functional approaches to study brain networks.
This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.​