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Intellectual disability (ID) is a condition with a myriad of aetiologies. Given the aetiological heterogeneity, it is logical that researchers are beginning to find syndrome specific cognitive strengths and weaknesses within the ID population. Knowledge regarding such strengths and weaknesses has important implications for education strategies and interventions. In the context of education research, the three frontally mediated functions of sustained attention, response inhibition and working memory can be grouped under the umbrella term cognitive control. There has been very little research examining sustained attention and response inhibition in Down syndrome and autism and ID, and also negligible research into working memory in autism and co-morbid ID. The only pocket of research in this field seems to be in the area of working memory in DS. A thorough literature search identified a clear lack of investigation of cognitive function for those with autism and ID, and also studies that systematically vary the modality of stimulus presentation. With both DS and autism and ID, most research has compared performances on task involving predominately visual or auditory processing, with few using multiple versions of the same task that differ only in the modality of presentation. Accordingly, the main aims of this study were, to firstly investigate the three aspects of cognitive control in adolescents with DS, autism and ID and a comparison group with non-specific intellectual disability (NSID). Secondly, performances were compared using identical versions of tasks that had either a visual or auditory mode of presentation. The final aim of this research was to consider the results in the context of classroom performance, and provide recommendations for the education sector. Participants were recruited from schools and support organisations throughout metropolitan and regional areas of Victoria, Australia. Participants were administered a two-hour test battery of clinical and experimental neuropsychological tasks at either their school or at Monash University. Data from 15 males with DS, 12 males with autism and co-morbid and 12 males with non specific intellectual disability (NSID) were utilised for this research. With regard to sustained attention, the groups were compared on omission errors from visual and auditory versions of the child friendly version of the sustained attention to response task (SART). The group with DS had more difficulty sustaining their attention than both the groups with autism and ID and NSID. The males with autism and ID performed similarly to those with NSID on sustained attention tasks. Modality differences were not observed in any of the groups. For response inhibition, the groups were compared on commission errors from the SART. While no group differences were evident overall, a double dissociation arose between the group with DS and the group with autism and ID. The group with DS were stronger in the visual condition than the group with autism and ID, while the reverse was evident in the auditory condition. For working memory, a novel task was developed for the purposes of this research, which also had visual and auditory versions. On this task, the group with DS performed similarly to the group with autism and ID, with both groups demonstrating poorer performances than the group with NSID. Results from this research suggest that individuals with DS may benefit from more support than their peers in maintaining attention, with targeted strategies capitalising on visual strengths in the classroom. The results with regard to response inhibition also support this approach, and also suggest the converse for those with autism, i.e. presenting material verbally, provided it is kept concise. Both the group with DS and the group with autism and ID had weaknesses in working memory when compared to NSID, with broad recommendations involving reducing the amount of information to be processed at any one point in time as well as providing visual or verbal (as appropriate) prompts and cues to reduce the need to hold information in working memory. This study highlights the need for an individual approach to supporting those with an ID, both within the classroom and beyond. It provides suggestions for future education and intervention strategies that are well informed by the growing body of evidence supporting unique patterns of cognitive strengths and weaknesses within both DS and autism and ID.
From translating the patient’s medical records and test results to providing recommendations, the neuropsychological evaluation incorporates the science and practice of neuropsychology, neurology, and psychological sciences. The Little Black Book of Neuropsychology brings the practice and study of neuropsychology into concise step-by-step focus—without skimping on scientific quality. This one-of-a-kind assessment reference complements standard textbooks by outlining signs, symptoms, and complaints according to neuropsychological domain (such as memory, language, or executive function), with descriptions of possible deficits involved, inpatient and outpatient assessment methods, and possible etiologies. Additional chapters offer a more traditional approach to evaluation, discussing specific neurological disorders and diseases in terms of their clinical features, neuroanatomical correlates, and assessment and treatment considerations. Chapters in psychometrics provide for initial understanding of brain-behavior interpretation as well as more advanced principals for neuropsychology practice including new diagnostic concepts and analysis of change in performance over time. For the trainee, beginning clinician or seasoned expert, this user-friendly presentation incorporating ‘quick reference guides’ throughout which will add to the practice armentarium of beginning and seasoned clinicians alike. Key features of The Black Book of Neuropsychology: Concise framework for understanding the neuropsychological referral. Symptoms/syndromes presented in a handy outline format, with dozens of charts and tables. Review of basic neurobehavioral examination procedure. Attention to professional issues, including advances in psychometrics and diagnoses, including tables for reliable change for many commonly used tests. Special “Writing Reports like You Mean It” section and guidelines for answering referral questions. Includes appendices of practical information, including neuropsychological formulary. The Little Black Book of Neuropsychology is an indispensable resource for the range of practitioners and scientists interested in brain-behavior relationships. Particular emphasis is provided for trainees in neuropsychology and neuropsychologists. However, the easy to use format and concise presentation is likely to be of particular value to interns, residents, and fellows studying neurology, neurological surgery, psychiatry, and nurses. Finally, teachers of neuropsychological and neurological assessment may also find this book useful as a classroom text. "There is no other book in the field that covers the scope of material that is inside this comprehensive text. The work might be best summed up as being a clinical neuropsychology postdoctoral residency in a book, with the most up to date information available, so that it is also an indispensible book for practicing neuropsychologists in addition to students and residents...There is really no book like this available today. It skillfully brings together the most important foundationsof clinical neuropsychology with the 'nuts and bolts' of every facet of assessment. It also reminds the more weathered neuropsychologists among us of the essential value of neuropsychological assessment...the impact of the disease on the patient’s cognitive functioning and behavior may only be objectively quantified through a neuropsychological assessment." Arch Clin Neuropsychol (2011) first published online June 13, 2011 Read the full review acn.oxfordjournals.org
The last forty years of research have demonstrated that working memory (WM) is a key concept for understanding higher-order cognition. To give an example, WM is involved in reading comprehension, problem solving and reasoning, but also in a number of everyday life activities. It has a clear role in the case of atypical development too. For instance, numerous studies have shown an impairment in WM in individuals with learning disabilities (LD) or intellectual disabilities (ID); and several researchers have hypothesized that this can be linked to their difficulties in learning, cognition and everyday life. The latest challenge in the field concerns the trainability of WM. If it is a construct central to our understanding of cognition in typical and atypical development, then specific intervention to sustain WM performance might also promote changes in cognitive processes associated with WM. The idea that WM can be modified is debated, however, partly because of the theoretical implications of this view, and partly due to the generally contradictory results obtained so far. In fact, most studies converge in demonstrating specific effects of WM training, i.e. improvements in the trained tasks, but few transfer effects to allied cognitive processes are generally reported. It is worth noting that any maintenance effects (when investigated) are even more meagre. In addition, a number of methodological concerns have been raised in relation to the use of: 1. single tasks to assess the effects of a training program; 2. WM tasks differing from those used in the training to assess the effects of WM training; and 3. passive control groups. These and other crucial issues have so far prevented any conclusions from being drawn on the efficacy of WM training. Bearing in mind that the opportunity to train WM could have a huge impact in the educational and clinical settings, it seems fundamentally important to shed more light on the limits and potential of this line of research. The aim of the research discussed here is to generate new evidence on the feasibility of training WM in individuals with LD and ID. There are several questions that could be raised in this field. For a start, can WM be trained in this population? Are there some aspects of WM that can be trained more easily than others? Can a WM training reduce the impact of LD and ID on learning outcomes, and on everyday living? What kind of training program is best suited to the promotion of such changes?
We know considerably more about persons with intellectual disability than we did even a decade ago. Seeking to improve and increase upon this knowledge, this book provides a map to continue sophisticated and precise research, to inspire professionals involved with intellectual disability, and to better the lives of persons affected by it.
This book highlights the behavioral and neurobiological issues relevant for drug development, reviews evidence for an innovative approach for drug discovery and presents perspectives on multiple special topics ranging from therapeutic drug use in children, emerging technologies and non-pharmacological approaches to cognitive enhancement.
Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Planning. Attention. Memory. Self-regulation. These and other core cognitive and behavioral operations of daily life comprise what we know as executive functioning (EF). But despite all we know, the concept has engendered multiple, often conflicting definitions and its components are sometimes loosely defined and poorly understood. The Handbook of Executive Functioning cuts through the confusion, analyzing both the whole and its parts in comprehensive, practical detail for scholar and clinician alike. Background chapters examine influential models of EF, tour the brain geography of the executive system and pose salient developmental questions. A section on practical implications relates early deficits in executive functioning to ADD and other disorders in children and considers autism and later-life dementias from an EF standpoint. Further chapters weigh the merits of widely used instruments for assessing executive functioning and review interventions for its enhancement, with special emphasis on children and adolescents. Featured in the Handbook: The development of hot and cool executive function in childhood and adolescence. A review of the use of executive function tasks in externalizing and internalizing disorders. Executive functioning as a mediator of age-related cognitive decline in adults. Treatment integrity in interventions that target executive function. Supporting and strengthening working memory in the classroom to enhance executive functioning. The Handbook of Executive Functioning is an essential resource for researchers, scientist-practitioners and graduate students in clinical child, school and educational psychology; child and adolescent psychiatry; neurobiology; developmental psychology; rehabilitation medicine/therapy and social work.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Neuropsychology of Autism provides an up-to-date summary on the neuropsychology of autism spectrum disorders (ASD), written by leaders in the field. It summarizes current knowledge about neurochemistry, neuroanatomy, genetics, and clinical presentations and provides helpful discussions on key functions such as language, memory, attention, executive functions, social cognition, motor and sensory functioning.
A clear, engaging writing style, hundreds of full-color images, and new information throughout make Volpe’s Neurology of the Newborn, 6th Edition, an indispensable resource for those who provide care for neonates with neurological conditions. World authority Dr. Joseph Volpe, along with Dr. Terrie E. Inder and other distinguished editors, continue the unparalleled clarity and guidance you’ve come to expect from the leading reference in the field – keeping you up to date with today’s latest advances in diagnosis and management, as well as the many scientific and technological advances that are revolutionizing neonatal neurology. Features a brand new, full-color design with hundreds of new figures, tables, algorithms, and micrographs. Includes two entirely new chapters: Neurodevelopmental Follow-Up and Stroke in the Newborn; a new section on Neonatal Seizures; and an extensively expanded section on Hypoxic-Ischemia and Other Disorders. Showcases the experience and knowledge of a new editorial team, led by Dr. Joseph Volpe and Dr. Terrie E. Inder, Chair of the Department of Pediatric Newborn Medicine at Brigham and Women’s Hospital, all of whom bring a wealth of insight to this classic text. Offers comprehensive updates from cover to cover to reflect all of the latest information regarding the development of the neural tube; prosencephalic development; congenital hydrocephalus; cerebellar hemorrhage; neuromuscular disorders and genetic testing; and much more. Uses an improved organization to enhance navigation.