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This book contains a series of review chapters from the world's leaders in herpesvirus research. It is designed as a tribute to the famous virologist Prof Bernard Roizman. Former trainees of Prof Roizman were invited to contribute to this volume. The chapters cover all eight of the human herpesviruses, and the topics discussed span the past six decades of this exciting research field.
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitive source of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
The story of the rise and fall of smallpox, one of the most savage killers in the history of mankind, and the only disease ever to be successfully exterminated (30 years ago next year) by a public health campaign.
Billions of dollars are spent every year on research into targeted therapies for cancer. That’s why it’s more than ever crucial for the thousands of scientists working in the field to keep right up to date with the cutting edge. This fascinating collection of material goes a long way to helping them do so, featuring as it does contributions to a crucial international meeting in Italy. The meeting provided a forum for scientists and clinicians working in cancer drug discovery and therapy to share their opinions and experiences. The text here offers readers an overview of diverse approaches, ranging from drug discovery to cellular therapy. Overall, the book addresses the key question of whether ultimately targeted therapy in cancer will be a myth or a reality.
Horace G. Danner’s A Thesaurus of English Word Roots is a compendium of the most-used word roots of the English language. As Timothy B. Noone notes in his foreword: “Dr. Danner’s book allows you not only to build up your passive English vocabulary, resulting in word recognition knowledge, but also gives you the rudiments for developing your active English vocabulary, making it possible to infer the meaning of words with which you are not yet acquainted. Your knowledge can now expand and will do so exponentially as your awareness of the roots in English words and your corresponding ability to decode unfamiliar words grows apace. This is the beginning of a fine mental linguistic library: so enjoy!” In A Thesaurus of English Word Roots, all word roots are listed alphabetically, along with the Greek or Latin words from which they derive, together with the roots’ original meanings. If the current meaning of an individual root differs from the original meaning, that is listed in a separate column. In the examples column, the words which contain the root are then listed, starting with their prefixes, for example, dysacousia, hyperacousia. These root-starting terms then are followed by terms where the root falls behind the word, e.g., acouesthesia and acoumeter. These words are followed by words where the root falls in the middle or the end, as in such terms as bradyacusia and odynacusis.. In this manner, A Thesaurus of English Word Roots places the word in as many word families as there are elements in the word. This work will interest linguists and philologists and anyone interested in the etymological aspects of English language.
This is a professional level major reference work containing information, in A-Z format, on herb-drug, herb-supplement, herb -food and herb-laboratory test interactions; all of which is data referenced. Commercial herbal medicinal products are increasingly consumed on a regular basis by people in the developed world. Often such products are taken concurrently with conventional medicines, frequently without the knowledge of health care professionals. As more evidence has become available, there has been an increasing awareness of the potential and actual problems of interactions, often dangerous, between conventional medicines and herbal medicines. This proposed new major reference brings together available data on approximately 200 of the most commonly used herbal medicines in highly structured, rigorously scientific monographs. Although our texts on herbal medicines and drug interactions include the major well-known interactions, this text is able to treat the subject in considerably more detail.
"The theme of The World Development Report 2007 is youth - young people between the ages of 12 to 24. As this population group seeks identity and independence, they make decisions that affect not only their own well-being, but that of others, and they do this in a rapidly changing demographic and socio-economic environment. Supporting young people's transition to adulthood poses important opportunities and risky challenges for development policy. Are education systems preparing young people to cope with the demands of changing economies? What kind of support do they get as they enter the labor market? Can they move freely to where the jobs are? What can be done to help them avoid serious consequences of risky behavior, such as death from HIV-AIDS and drug abuse? Can their creative energy be directed productively to support development thinking? The report will focus on crucial capabilities and transitions in a young person's life: learning for life and work, staying healthy, working, forming families, and exercising citizenship. For each, there are opportunities and risks; for all, policies and institutions matter."