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Multivariate Analysis in the Pharmaceutical Industry provides industry practitioners with guidance on multivariate data methods and their applications over the lifecycle of a pharmaceutical product, from process development, to routine manufacturing, focusing on the challenges specific to each step. It includes an overview of regulatory guidance specific to the use of these methods, along with perspectives on the applications of these methods that allow for testing, monitoring and controlling products and processes. The book seeks to put multivariate analysis into a pharmaceutical context for the benefit of pharmaceutical practitioners, potential practitioners, managers and regulators. Users will find a resources that addresses an unmet need on how pharmaceutical industry professionals can extract value from data that is routinely collected on products and processes, especially as these techniques become more widely used, and ultimately, expected by regulators. - Targets pharmaceutical industry practitioners and regulatory staff by addressing industry specific challenges - Includes case studies from different pharmaceutical companies and across product lifecycle of to introduce readers to the breadth of applications - Contains information on the current regulatory framework which will shape how multivariate analysis (MVA) is used in years to come
How the marriage of Industry 4.0 and the Circular Economy can radically transform waste management—and our world Do we really have to make a choice between a wasteless and nonproductive world or a wasteful and ultimately self-destructive one? Futurist and world-renowned waste management scientist Antonis Mavropoulos and sustainable business developer and digital strategist Anders Nilsen respond with a ringing and optimistic “No!” They explore the Earth-changing potential of a happy (and wasteless) marriage between Industry 4.0 and a Circular Economy that could—with properly reshaped waste management practices—deliver transformative environmental, health, and societal benefits. This book is about the possibility of a brand-new world and the challenges to achieve it. The fourth industrial revolution has given us innovations including robotics, artificial intelligence, 3D-printing, and biotech. By using these technologies to advance the Circular Economy—where industry produces more durable materials and runs on its own byproducts—the waste management industry will become a central element of a more sustainable world and can ensure its own, but well beyond business as usual, future. Mavropoulos and Nilsen look at how this can be achieved—a wasteless world will require more waste management—and examine obstacles and opportunities such as demographics, urbanization, global warming, and the environmental strain caused by the rise of the global middle class. · Explore the new prevention, reduction, and elimination methods transforming waste management · Comprehend and capitalize on the business implications for the sector · Understand the theory via practical examples and case studies · Appreciate the social benefits of the new approach Waste-management has always been vital for the protection of health and the environment. Now it can become a crucial role model in showing how Industry 4.0 and the Circular Economy can converge to ensure flourishing, sustainable—and much brighter—future.
Jackups, semisubmersibles and drillships are the marine vessels used to drill offshore wells and are referred to collectively as mobile offshore drilling units (MODUs). MODUs are supplied through newbuild construction and operate throughout the world in highly competitive regional markets. The Offshore Drilling Industry and Rig Construction Market in the Gulf of Mexico examines the global MODU service and construction industry and describes the economic impacts of rig construction in the United States. The industrial organization and major players in the contract drilling and construction markets are described and categorized. Dayrates in the contract drilling market are evaluated and hypotheses regarding dayrate factors are tested. Models of contractor decision-making are developed, including a net-present value model of newbuilding investment and stacking decisions, and market capitalization models are derived. Jackup construction shipyards and processes are reviewed along with estimates of labor, equipment, and material cost in U.S. construction. Derivation of newbuild and replacement cost functions completes the treatise. The comprehensive and authoritative coverage of The Offshore Drilling Industry and Rig Construction Market in the Gulf of Mexico makes it an ideal reference for engineers, industry professionals, policy analysts, government regulators, academics and other readers wanting to learn more about this important and fascinating industry.