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Used in the production of a wide number of fine chemicals and pharmaceuticals, the Friedel-Crafts acylation reaction represents a synthetic process of great interest to organic chemists of academia and industry. Nearly 40 years since the last major treatise on the topic and reflecting the growing emphasis on green technology, Advances in Friedel-Cr
Heteroarenes are among the most prevalent structural units in natural products, pharmaceuticals, agrochemicals, and other compounds of scientific or commercial interest. In the last decade, a broad range of novel synthetic methods has been developed to not only facilitate construction of the heteroarene motif, but to enable its modification through direct C H functionalization. This Handbook describes 117 key reagents for selective heteroarene functionalization reactions, including both traditional and transition metal-catalyzed C H functionalization. Since these reactions typically involve one heteroarene, a coupling partner and a catalyst, the handbook not only focuses on the catalyst itself but also contains other key reaction species. All the information compiled in this volume is also available in electronic format on Wiley Online Library. The 117 reagents represented here are but a small fraction of the ca. 5,000 reagents available in the electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS). e-EROS offers various search interfaces to locate reagents of interest, including chemical structure, substructure and reactions search modes. e-EROS is updated regularly with new and updated entries.
The Sixth Edition of a classic in organic chemistry continues its tradition of excellence Now in its sixth edition, March's Advanced Organic Chemistry remains the gold standard in organic chemistry. Throughout its six editions, students and chemists from around the world have relied on it as an essential resource for planning and executing synthetic reactions. The Sixth Edition brings the text completely current with the most recent organic reactions. In addition, the references have been updated to enable readers to find the latest primary and review literature with ease. New features include: More than 25,000 references to the literature to facilitate further research Revised mechanisms, where required, that explain concepts in clear modern terms Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries A revised Appendix B to facilitate correlating chapter sections with synthetic transformations
Comprehensively teaches all of the fundamentals of fragrance chemistry Ernest Beaux, the perfumer who created Chanel No. 5, said, "One has to rely on chemists to find new aroma chemicals creating new, original notes. In perfumery, the future lies primarily in the hands of chemists." This book provides chemists and chemists-to-be with everything they need to know in order to create welcome new fragrances for the world to enjoy. It offers a simplified introduction into organic chemistry, including separation techniques and analytical methodologies; discusses the structure of perfume creation with respect to the many reactive ingredients in consumer products; and shows how to formulate effective and long-lasting scents. Fundamentals of Fragrance Chemistry starts by covering the structure of matter in order to show how its building blocks are held together. It continues with chapters that look at hydrocarbons and heteroatoms. A description of the three states of matter and how each can be converted into another is offered next, followed by coverage of separation and purification of materials. Other chapters examine acid/base reactions; oxidation and reduction reactions; perfume structure; the mechanism of olfaction; natural and synthetic fragrance ingredients; and much more. -Concentrates on aspects of organic chemistry, which are of particular importance to the fragrance industry -Offers non-chemists a simplified yet complete introduction to organic chemistry?from separation techniques and analytical methodologies to the structure of perfume creation -Provides innovative perfumers with a framework to formulate stable fragrances from the myriad of active ingredients available -Looks at future trends in the industry and addresses concerns about sustainability and quality management Fundamentals of Fragrance Chemistry is an ideal resource for students who are new to the subject, as well as for chemists and perfumers already working in this fragrant field of science.