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Free Radicals in Biology, Volume II is a nine-chapter text that describes the complexities in the chemical and physical behavior of free radicals. After briefly providing an overview of the biology of pyridinyl radicals, this book goes on discussing the role of glutathione in the cell and the reactions of single oxygen and its role in photochemical smog and in cellular chemistry. These topics are followed by a discussion on the production of free radicals from dry tissue. The subsequent chapters describe some of the key reactions in photochemical smog, including reaction studies by computer simulation, as well as the specific reactive materials that are present in smog. These chapters also look into the chemistry of nitrogen oxides and ozone, which are some of the most important reactions in photochemical smog. The concluding chapters explore the radiation damage to proteins and radiation protection and radical reactions produced by radiation in nucleic acids. Chemists, biologists, and physicists will find this text invaluable.
For more than a century, science has cultivated a sober public image for itself. But as bestselling author Michael Brooks explains, the truth is very different: many of our most successful scientists have more in common with libertines than librarians. This thrilling exploration of some of the greatest breakthroughs in science reveals the extreme lengths some scientists go to in order to make their theories public. Fraud, suppressing evidence and unethical or reckless PR games are sometimes necessary to bring the best and most brilliant discoveries to the world's attention. Inspiration can come from the most unorthodox of places, and Brooks introduces us to Nobel laureates who get their ideas through drugs, dreams and hallucinations. Science is a highly competitive and ruthless discipline, and only its most determined and passionate practitioners make headlines - and history. To succeed, knowledge must be pursued by any means: in science, anything goes. 'Brooks is an exemplary science writer' William Leith, Daily Telegraph
Biological Oxidation Systems, Volume II discusses the various antioxidants and antioxidant enzymes that play significant roles in protecting cells from deleterious reactions between their structural/functional components and the free radicals. This book examines the myriad chemical reactions of a cell's metabolic activity that produce a variety of free radicals. Comprised of three parts encompassing 35 chapters, this volume starts with an overview of the metabolism of xenobiotics during arachidonic acid metabolism. This book then discusses the various causes of human cancers and diseases, which include exposure to environmental chemicals and other toxicants. This text considers the dietary habits and nutritional factors that play an important role in the causation and development of several human cancers, including cancer of the breast, colon, prostate, and other organs. Other chapters discuss the toxic effects of several xenobiotics that involve free-radical mechanisms. Biochemists, biophysicists, microbiologists, organic chemists, food chemists, and medical scientists will find this book extremely useful.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Written by leading experts, this book reviews the current research evidence for the health benefits of a diet rich in olive oil. It focuses on the role of olive oil in reducing the incidence of certain types of cancer, cardiovascular diseases, inflammatory bowel disease and diabetes, and the effect of olive oil on the immune system.
This is the premier, single-source reference on redox biochemistry, a rapidly emerging field. This reference presents the basic principles and includes detailed chapters focusing on various aspects of five primary areas of redox biochemistry: antioxidant molecules and redox cofactors; antioxidant enzymes; redox regulation of physiological processes; pathological processes related to redox; and specialized methods. This is a go-to resource for professionals in pharmaceuticals, medicine, immunology, nutrition, and environmental fields and an excellent text for upper-level students.
The material presented in this book deals with basic mechanisms of free radical reactions in autoxidation processes and anitoxidant suppression of autoxidation of foods, biochemical models and biologi cal systems. Autoxidation in foods and corresponding biological effects are usually approached separately although recent mechanistic developments in the biochemistry and free radical chemistry of per oxides and their precursors tend to bring these two fields closer. Apparent ability of antioxidants in diets to reduce the inci dence of cancer has resulted in scrutiny of autoxidized products and their precursors as possibly toxic, mutagenic and carcinogenic agents. Mechanisms of any of these effects have been barely ad dressed. Yet we know now that free radicals, as esoteric as they were only a few decades ago, are being discovered in foods, biochem ical and biological systems and do play a role in the above-mentioned causalities. The purpose of the Workshop and the resulting book was to give a unifying approach towards study of beneficial and deleterious effects of autoxidation, based on rigorous scientific considerations. It is our hope that the material presented in this book will not only provide a review of the "state of the art" of autoxidation and anti oxidants, but also reflect the interaction which occurred during the Workshop between workers using model sytems, and food and biological systems.
First multi-year cumulation covers six years: 1965-70.
Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The series is still valid and useful after five or ten years. More information as well as the electronic version of the whole content is available at: springerlink.com.