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This new book is an up-to-date review of the clinical, epidemiological, and cytogenetic aspects of the fragile X (Martin-Bell) syndrome--the most common genetic cause of mental retardation after Down syndrome. The book includes the latest research findings concerning diagnosis on the basis of the appearance of a fragile site in cultured lymphocytes. It assumes little prior knowledge of the subject, and provides a clearly written, easy-to-understand discussion previously unavailable in a single reference source. The book will be of special interest to molecular biologists, cytogeneticists, medical geneticists, and clinicians and other professionals working with the mentally handicapped.
The New York Times best-selling book exploring the counterproductive reactions white people have when their assumptions about race are challenged, and how these reactions maintain racial inequality. In this “vital, necessary, and beautiful book” (Michael Eric Dyson), antiracist educator Robin DiAngelo deftly illuminates the phenomenon of white fragility and “allows us to understand racism as a practice not restricted to ‘bad people’ (Claudia Rankine). Referring to the defensive moves that white people make when challenged racially, white fragility is characterized by emotions such as anger, fear, and guilt, and by behaviors including argumentation and silence. These behaviors, in turn, function to reinstate white racial equilibrium and prevent any meaningful cross-racial dialogue. In this in-depth exploration, DiAngelo examines how white fragility develops, how it protects racial inequality, and what we can do to engage more constructively.
Aid agencies increasingly consider anti-corruption activities important for economic development and poverty reduction in developing countries. In the first major comparative study of work by the World Bank, the European Commission and the UNDP to help governments in fragile states counter corruption, Jesper Johnsøn finds significant variance in strategic direction and common failures in implementation.
Any system of government is comprised of several dimensions of functionality, which must all work in congruence. When any part of the system is dysfunctional, the government’s stability becomes fractured and societal problems can arise. Political Discourse in Emergent, Fragile, and Failed Democracies examines the effects of unstable democratic systems of government in modern society, providing an imperative analysis on political communications from such nations. Highlighting real-world examples on the constraints seen in malfunctioning or emerging governments, this book is a pivotal reference source for policy makers, researchers, academicians, and upper-level students interested in politics and governance.
Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.
Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field
This report serves as a tool to better monitor the levels, timing and composition of resource flows to fragile states, and presents salient facts on aid flows to fragile states, the impact on fragile states of the three crises and the need for a whole-of-government response.
The Americas face many security challenges, including drug trafficking, organized crime, guerrilla movements, terrorism, and environmental challenges. Experts have long debated whether some countries in the region can be classified as failed states. While various states in the Americas have been labeled as failed states, calling a country a failed state is quite controversial and requires a precise definition of what constitutes a failed state. This book instead discusses fragile states in the Americas. Fragile states are weak states that are fertile grounds for organized crime groups and illegal actors as such groups are able to infiltrate the state apparatus through corruption. The goal of this book is to examine fragile states in the region and the major security challenges that these states face. The cause of state fragility is different for various states. Theoretically, the work will conceptualize the meaning of fragility as it relates to state survival and autonomy. Empirically, the book focuses on contemporary threats to the survival of fragile states in the Americas. The book explains and analyzes the main political, security, and economic challenges of these states. It employs a wide array of cases that delve into the security and economic threats and priorities of states in the Americas.
Fragile Resonance describes the paths carers take as they make meaning of their experiences and find a sense of moral purpose to sustain them and guide their decisions. When a parent or partner becomes frail or disabled, often a family member assumes responsibility for their care. But family care is a physically and emotionally exhausting undertaking. Carers experience moments of profound connection as well as pain and grief. Carers ask themselves questions about the meaning of family, their entitlement to support, and their capacity to understand and sympathize with another person's pain. Based on his research gathering stories of family carers in Japan and England, Jason Danely traces how care transforms individual sensibilities and the roles of cultural narratives and imagination in shaping these transformations, which persist even after the care recipient has died. Throughout Fragile Resonance, Danely examines the implications of unpaid carer's experiences for challenging and enhancing social policies and institutions, highlighting innovative alternatives grounded in the practical ethics of care.
Gathers poems that combine an examination of contemporary society with views of the natural world and human relationships.