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This book closes a current gap by providing the scientific basis for consumer exposure assessment in the context of regulatory risk assessment. Risk is defined as the likelihood of an event occurring and the severity of its effects. The margin between the dose that leads to toxic effects and the actual dose of a chemical is identified by estimating population exposure. The objective of this book is to provide an introduction into the scientific principles of consumer exposure assessment, and to describe the methods used to estimate doses of chemicals, the statistics applied and computer tools needed. This is presented through the backgrounds of the special fields in exposure analysis, such as exposure via food and by the use of consumer products, toys, clothing and other items. As a general concept, human exposure is also understood to include exposure via the environment and from the work setting. In this context, the specific features of consumer exposure are pointed out and put into the context of regulation, in particular food safety, chemicals safety (REACh) and consumer product safety. The book is structured into three parts: The first part deals with the general concepts of consumer exposure as part of the overall risk analysis framework of risk characterization, risk assessment and risk communication. It describes the three basic features of exposure assessment (i) the exposure scenario (ii) the exposure model and (iii) the exposure parameters, addressing external and internal exposure. Also, the statistical presentation of data to characterize populations, in connection with variability, uncertainty and quality of information and the presentation of exposure evaluation results is described. The second part deals with the specific issues of exposure assessment, exposure via food consumption, exposure from use of consumer products, household products, toys, cosmetic products, textiles, pesticides and others. This part also covers methods for acquisition of data for exposure estimations, including the relevant information from regulations needed to perform an accurate exposure assessment. The third part portrays a prospect for further needs in the development and improvement of consumer exposure assessment, as well as international activities and descriptions of the work of institutions that are involved in exposure assessment on the regulatory and scientific level. And conversely, it creates the rationale for the exposure assessment details necessary to satisfy regulatory needs such as derivation of upper limits and risk management issues.
This book explores the regulation of pesticides in the European Union in order to reveal the complex, controversial, and contested nature of an assessment system proudly declared by the EU to be ‘the strictest in the world’. The current regulatory framework is based on Regulation 1107/2009, which substantially reformed the previous system. The analysis describes the new criteria and procedures for the authorization of active substances to be used in the production of pesticides, traces the lengthy policy formulation process, and identifies factors that made policy change possible. Further, the book illustrates the current controversies that characterise the implementation of Regulation 1107/2009: the ban of pesticides harmful to pollinators, the renewal of the authorization of glyphosate, and the definition of criteria for the assessment of endocrine disruption. The author provides information on policy outcomes and highlights persisting shortcomings in the enforcement of EU regulation. This book will appeal to students and scholars from a variety of disciplines, including political science, political sociology, and public policy.
"With the passage of the Frank R. Lautenberg Chemical Safety for the 21st Century Act on June 22, 2016, the main body of chemical management law in the United States changed dramatically. This guide summarizes the new law, highlights the changes that will have the greatest impact, and offers pertinent analysis on the implementation of the new law."--
Welcome to the proceedings of the Seventh International Conference of the UK Systems Society being held at York University, United Kingdom from July 7th to 10th, 2002. It is a pleasure to be able to share with you this collection ofpapers that have been contributed by systems thinkers from around the world. As with previous UKSS conferences, the aim ofthis conference is to encourage debate and promote development of pertinent issues in systems theory and practice. In current times where the focus has moved from 'information' to 'knowledge' and where 'knowledge management', of everyday speak, it seemed fitting to 'knowledge assets' and so on, have become part offer a conference title of'Systems Theory and Practice in the Knowledge Age'. In keeping with another tradition of previous conferences, the UKSS Conference 2002 Committee decided to compile a collection ofdelegates' papers before the event as a platform from which to launch discussions in York. Ideas presented in the following papers will, undoubtedly, be developed during the dialogue generated at the conference and new papers will emerge. In his abstract for his plenary at this conference, Professor Peter Checkland throws down the gauntlet to systems thinking and its relevance in the knowledge age with the following statement: "30 Years In The Systems Movement: Disappointments I Have Known and Hopes/or the Future Springing from a lunchtime conversation at an American University, the Systems Movement is now nearly 50 years old.
Environmental Systems Science: Theory and Practical Applications looks at pollution and environmental quality from a systems perspective. Credible human and ecological risk estimation and prediction methods are described, including life cycle assessment, feasibility studies, pollution control decision tools, and approaches to determine adverse outcome pathways, fate and transport, sampling and analysis, and cost-effectiveness. The book brings translational science to environmental quality, applying groundbreaking methodologies like informatics, data mining, and applications of secondary data systems. Multiple human and ecological variables are introduced and integrated to support calculations that aid environmental and public health decision making. The book bridges the perspectives of scientists, engineers, and other professionals working in numerous environmental and public health fields addressing problems like toxic substances, deforestation, climate change, and loss of biological diversity, recommending sustainable solutions to these and other seemingly intractable environmental problems. The causal agents discussed include physical, chemical, and biological agents, such as per- and polyfluoroalkyl substances (PFAS), SARS-CoV-2 (the COVID-19 virus), and other emerging contaminants. - Provides an optimistic and interdisciplinary approach, underpinned by scientific first principles and theory to evaluate pollutant sources and sinks, applying biochemodynamic methods, measurements and models - Deconstructs prior initiatives in environmental assessment and management using an interdisciplinary approach to evaluate what has worked and why - Lays out a holistic understanding of the real impact of human activities on the current state of pollution, linking the physical sciences and engineering with socioeconomic, cultural perspectives, and environmental justice - Takes a life cycle view of human and ecological systems, from the molecular to the planetary scale, integrating theories and tools from various disciplines to assess the current and projected states of environmental quality - Explains the elements of risk, reliability and resilience of built and natural systems, including discussions of toxicology, sustainability, and human-pollutant interactions based on spatial, biological, and human activity information, i.e. the exposome
Significant New Use - Rules on Certain Chemical Substances (US Environmental Protection Agency Regulation) (EPA) (2018 Edition) The Law Library presents the complete text of the Significant New Use - Rules on Certain Chemical Substances (US Environmental Protection Agency Regulation) (EPA) (2018 Edition). Updated as of May 29, 2018 EPA is promulgating significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for 57 chemical substances which were the subject of premanufacture notices (PMNs). The applicable review periods for the PMNs submitted for these 57 chemical substances all ended prior to June 22, 2016 (i.e., the date on which President Obama signed into law the Frank R. Lautenberg Chemical Safety for the 21st Century Act which amends TSCA). Thirty-four of these chemical substances are subject to TSCA section 5(e) consent orders issued by EPA. This action requires persons who intend to manufacture (defined by statute to include import) or process any of these 57 chemical substances for an activity that is designated as a significant new use by this rule to notify EPA at least 90 days before commencing that activity. The required notification initiates EPA's evaluation of the intended use within the applicable review period. Manufacture and processing for the significant new use is unable to commence until EPA has conducted a review of the notice, made an appropriate determination on the notice, and take such actions as are required with that determination. This book contains: - The complete text of the Significant New Use - Rules on Certain Chemical Substances (US Environmental Protection Agency Regulation) (EPA) (2018 Edition) - A table of contents with the page number of each section
Chemical Assessments: Low Productivity and New Interagency Review Process Limit the Usefulness and Credibility of EPA's Integrated Risk Information System
The Cambridge Aerospace Dictionary is an authoritative and accessible reference useful to scholars and enthusiasts alike. This dictionary is an essential tool for professionals involved in the aerospace industry and flight, and for anyone who must read and understand the technical literature of the aerospace industry and about specific air and space craft. It is also an ideal reference for engineering and physics students encountering a subject replete with technical jargon and acronyms. Bill Gunston, one of the most widely read and respected aviation writers, has added more than 5,000 new terms and acronyms to this carefully updated volume. Terms used in the dictionary reflect the diverse and international nature of the aerospace industry and include brief explanations of aerospace materials and organizations. Gunston has scrupulously avoided terms specific to manufacturers, airlines, and armed forces in an effort to encourage clear communication and understanding among professionals.
This volume of proceedings reviews the status of risks entailed in the manufacture, handling, use and disposal of the chemicals on which we all depend and suggests further action for the protection of both the workplace and the natural environment.