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Abstract: The diagnosis and management of hyperlipidemic and hyperlipoproteinemic states are explored from various points of view. Epidemiological observations show an inverse relationship between high density lipoprotein levels and coronary heart disease. Biochemical findings indicate how lipoproteins interact and exert their physiological and pathophysiological effects. Lipids and lipoproteins, in general are discussed. The plasma cholesteral health consequences involve lipid distribution. Research, review and evolution of clinical trials of lipid lowering to prevent coronary heart disease are included. Specific topics include various aspects of hyperlipoproteinemia: classification, diagnosis, primary and secondary types, genetic characteristics, dietary and drug treatment, and surgical management.