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Fluorine Chemistry, Volume III: Biological Effects of Organic Fluorides focuses on the biological threats of fluorine-containing compounds. The book first looks at the toxicity of fluoroacetate. Acute human poisoning, chemical factors, cause of death, pharmacological properties, evidence of fluorocitrate, and sites of inhibition are discussed. The text notes the biological effects of phosphofluoridates. Toxicity of DFP and derivatives, DFP metabolism, studies on DFP32 metabolism, and enzymes hydrolyzing DFP are described. The book also looks at the effects of acute doses of fluorine-containing organic compounds. The effects of organic fluorine compounds on enzyme systems; metabolic effects of tyrosine analogs; local anesthetics; effects of organofluorine compounds on microorganisms; and miscellaneous pharmacological effects of organic fluorides are discussed. The text underscores the acute effects of organofluorine compounds in experimental animals. Tabulated representations that show the effects of fluorine-containing compounds on humans and animals are presented. The book is a valuable source of information for readers wanting to study the biological effects of fluorine-containing compounds.
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Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
Advances in High Temperature Chemistry, Volume 3 reviews and evaluates some techniques in high temperature chemistry. Comprised of six chapters, this volume first discusses the principles concerned with high temperature chemistry. After introducing short-range ordering in crystals, this book shows how to interpret liquid alloy activity measurements. It also covers various techniques such as photoionization mass spectroscopy, photoelectron spectroscopy, and microwave spectroscopy. This book ends with a discussion on oxahalides and other transition elements. Researchers and high temperature chemists will find this book useful.
Coverage For some time, we have contemplated a comprehensive review of the structures and force fields of the binary fluorides. This bibliography of 1498 references marks the first step of that effort. We are pub lishing this material now rather than waiting until the review is complete some two years hence because we believe that the information already accumulated will be of immediate use to a broad spectrum of researchers. Anyone ambitious enough to read through all the articles on binary fluorides will find that the struc tures and force fields of many of these molecules are at present unknown. For example, it has not been clearly established to which point group(s) the lanthanide trifluorides should be assigned. There remain interesting problems relating to the role of Jahn-Teller and pseudo-Jahn-Teller distortions in some of the transition metal fluorides such as VF , MoF , ReF , and ReF , to name only a few. One s s 6 7 also finds fascinating examples of large-amplitude motions, or pseudorotations, as they are often called, in such molecules as XeF 6, I F 7, and PF 5' For those binary fluorides whose equilibrium geometries are precisely known, there still exists the problem of accurately determining the harmonic force field. In a few cases, most notably the Group VA trifluorides, there has been some attempt made at extracting the cubic and quartic contributions to the force field.
Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.