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Therapeutic breakthroughs in medicine are usually accompanied by a wealth of data. Often they result in a change of disease treatment paradigms. Tacrolimus ointment is the first in the new class of steroid-free Topical Immunomodulators (TIMs), and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of T-cell mediated inflammatory skin diseases such as atopic dermatitis. This book gives an easy-to-read overview of the discovery and the development of Tacrolimus ointment for the treatment of atopic dermatitis. Summarising the largest clinical trial program ever conducted in dermatology for a new treatment with more than 13000 patients, it offers a detailed insight into the efficacy and safety profile of Tacrolimus ointment. Based on this large body of data and extensive personal experience, the authors offer practical and hands-on guidance for the physician as to when and how to use Tacrolimus ointment in daily practice.
Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing—atom by atom—both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS. You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.
Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular mass inhibitors, including inhibitors of cytokine convertases and oligonucleotide drugs. The potential use of natural inhibitors such as soluble receptors, interleukin-1 receptor antagonists, and anti-cytokine antibodies is detailed. This interesting book also covers intracellular signaling pathways induced by pro-inflammatory cytokines and the bio-modulatory activity of specific cytokines such as TGF-ß. Therapeutic Modulation of Cytokines will interest academic scientists in biochemistry, cell biology, pharmacology, and molecular biology and biological scientists in the pharmaceutical and biopharmaceutical industries.
Written by a leading researcher in immunology, ImmunoPharmaceuticals specifically focuses on immunologically active drugs recently tested for clinical activity or recently approved for medical use. Each chapter focuses on a single drug or class of drugs and discusses data from basic and preclinical research concerning mechanisms of action. Preclinical models are compared with clinical findings to allow the reader to evaluate the predictive value of those models. Featured drugs are being studied for therapy of cancer, arthritic disease, autoimmune disease, immunodeficiency disease, transplantation, and determination of sepsis. Overviews of the retinoids in cancer therapy and preclinical studies on flavonoids are featured.
This Revised Third Edition is now updated to reflect the 2005 emergency cardiac care guidelines. The need for hazardous materials emergency response has grown with the increased use of chemicals and the threat of terrorism. Designed for both the EMS field provider and first receivers in the hospital setting, this important resource provides field recognition and management guidelines for hazardous materials exposures and associated medical emergencies, including emergency care of exposed and contaminated patients. The 3rd edition has been expanded to provide responders with the information necessary to identify the scene of a terrorist act involving the use of hazardous materials, as well as triage procedures for chemical exposure and the management of a mass casualty incident. A total of 140 guidelines, cross-referenced to indexes, provide essential information on hazard classes and specific chemicals with initial hospital considerations. Descriptions of procedures, scene operations and support, medical surveillance, and suggested emergency equipment. Extensive indexes supply multiple ways to access important information to save critical time in the field. Content is updated to reflect the 2005 emergency cardiac care guidelines. Over 30 new WMD agent guidelines provide concise, consistent information on managing exposure to high-risk substances. Expanded size includes over 150 pages of new material. An expanded index and updated treatment guidelines are included. The treatment protocol section, drug protocol section, and EMS/hazardous materials operating procedures are updated and expanded. How to identify the scene of a terrorist act involving the use of hazardous materials. Information on mass casualty decontamination and crime scene identification will help reader formulate a plan before beginning to work.
This text examines FK 506, an immunosuppressant for recipients of solid organ transplants that can prevent allograft rejection. FK 506, like cyclosporine, inhibits calcium-dependent T-cell immune responses. FK 506 is the first drug that can substitute for cyclosporine as an immunosuppressant after organ transplantation.
To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.
With detailed contributions from more than 40 leading authorities on the topic, this Third Edition comprehensively explores the immunobiology, pathophysiology, and clinical manifestations of graft-versus-host disease (GVHD)-offering sections revealing the most up-to-date research on immune activation and dysregulation, the pathophysiology of target organ damage, and GVHD prevention and treatment.
Representing the treatment and management philosophy of Dr. Susan Mackinnon, Nerve Surgery provides extensive coverage of innovative surgical options as well as guidance on the management of complicated compression neuropathies. In addition to detailed information on tried-and-true as well as cutting-edge surgical techniques, it contains chapters on the basic principles of nerve surgery, such as "Anatomy and Physiology for the Peripheral Nerve Surgeon" and "Evaluation of the Patient with Nerve Injury or Nerve Compression." Key Features: More than 850 compelling full-color figures and photographs demonstrate key concepts Videos narrated by Dr. Mackinnon are available online Coverage of important conditions that can be treated non-operatively, such as neurogenic thoracic outlet syndrome and multilevel compression neuropathy Strategies and secondary procedures for failed nerve surgeries Dr. Mackinnon provides tips on how she manages complicated pain problems This book is a core reference for all plastic surgeons, neurosurgeons, orthopedic surgeons, hand surgeons, residents, and allied health specialists treating patients with nerve injuries.