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The enormous recent success of molecular developmental biology has yielded a vast amount of new information on the details of development. So much so that we risk losing sight of the underlying principles that apply to all development. To cut through this thicket, John Tyler Bonner ponders a moment in evolution when development was at its most basic--the moment when signaling between cells began. Although multicellularity arose numerous times, most of those events happened many millions of years ago. Many of the details of development that we see today, even in simple organisms, accrued over a long evolutionary timeline, and the initial events are obscured. The relatively uncomplicated and easy-to-grow cellular slime molds offer a unique opportunity to analyze development at a primitive stage and perhaps gain insight into how early multicellular development might have started. Through slime molds, Bonner seeks a picture of the first elements of communication between cells. He asks what we have learned by looking at their developmental biology, including recent advances in our molecular understanding of the process. He then asks what is the most elementary way that polarity and pattern formation can be achieved. To find the answer, he uses models, including mathematical ones, to generate insights into how cell-to-cell cooperation might have originated. Students and scholars in the blossoming field of the evolution of development, as well as evolutionary biologists generally, will be interested in what Bonner has to say about the origins of multicellular development--and thus of the astounding biological complexity we now observe--and how best to study it.
Kicking of a new four-book series by an Air Force Reserve captain and UFO authority, this title explores the future evolution of man and machine, in which the search for intelligent life becomes the catalyst of man's dreams--and the stars, man's destination. Original.
First demonstrated in 1928, color television remained little more than a novelty for decades as the industry struggled with the considerable technical, regulatory, commercial, and cultural complications posed by the medium. Only fully adopted by all three networks in the 1960s, color television was imagined as a new way of seeing that was distinct from both monochrome television and other forms of color media. It also inspired compelling popular, scientific, and industry conversations about the use and meaning of color and its effects on emotions, vision, and desire. In Bright Signals Susan Murray traces these wide-ranging debates within and beyond the television industry, positioning the story of color television, which was replete with false starts, failure, and ingenuity, as central to the broader history of twentieth-century visual culture. In so doing, she shows how color television disrupted and reframed the very idea of television while it simultaneously revealed the tensions about technology's relationship to consumerism, human sight, and the natural world.
A widely celebrated novelist gives us a generous collection of exhilarating short stories, proving that he is a master of this genre as well. Once again, "he reminds us," wrote The Miami Herald, "that great writing is a timeless art." After the stunning historical novels The Clearing and The Missing, Tim Gautreaux now ranges freely through contemporary life with twelve new stories and eight from previous collections. Most are set in his beloved Louisiana, many hard by or on the Mississippi River, others in North Carolina and even in midwinter Minnesota. But generally it's heat, humidity, and bugs that beset his people as they wrestle with affairs of the heart, matters of faith, and the pros and cons of tight-knit communities--a remarkable cast of characters, primarily of the working class, proud and knowledgeable about the natural or mechanical world, their lives marked by a prized stereo or a magical sewing machine retrieved from a locked safe, boats and card games and casinos, grandparents and grandchildren and those in between, their experiences leading them to the ridiculous or the scarifying or the sublime; most of them striving for what's right and good, others tearing off in the opposite direction.
Joel Rothschild and his friend Albert, both HIV positive, made a pact: whoever died first would attempt to "signal" the other from beyond. Joel wasn't sure he believed in psychic abilities, but from the day Albert died he began receiving messages. One message led Joel to a note Albert had left for him before he died. Another message told Joel to hang in there when he became sick, that he would get well - and he did.Albert's messages have changed not only Joel's life but the lives of many others who have been helped by messages Joel has delivered to them. Their stories and Joel's psychic awakening - a transformation from cynic to believer - are both amazing and reassuring.
In this book the author, an investigative journalist, traces the social history of marijuana from its origins to its emergence in the 1960s as a defining force in an ongoing culture war. He describes how the illicit marijuana subculture overcame government opposition and morphed into a multibillion-dollar industry. In 1996, Californians voted to legalize marijuana for medicinal purposes. Similar laws have followed in several other states, but not without antagonistic responses from federal, state, and local law enforcement. The author draws attention to underreported scientific breakthroughs that are reshaping the therapeutic landscape: medical researchers have developed promising treatments for cancer, heart disease, Alzheimer's, diabetes, chronic pain, and many other conditions that are beyond the reach of conventional cures. This book is an examination of the medical, recreational, scientific, and economic dimensions of the world's most controversial plant.
A unified treatment of the generation and analysis of brain-generated electromagnetic fields. In Brain Signals, Risto Ilmoniemi and Jukka Sarvas present the basic physical and mathematical principles of magnetoencephalography (MEG) and electroencephalography (EEG), describing what kind of information is available in the neuroelectromagnetic field and how the measured MEG and EEG signals can be analyzed. Unlike most previous works on these topics, which have been collections of writings by different authors using different conventions, this book presents the material in a unified manner, providing the reader with a thorough understanding of basic principles and a firm basis for analyzing data generated by MEG and EEG. The book first provides a brief introduction to brain states and the early history of EEG and MEG, describes the generation of electromagnetic fields by neuronal activity, and discusses the electromagnetic forward problem. The authors then turn to EEG and MEG analysis, offering a review of linear and matrix algebra and basic statistics needed for analysis of the data, and presenting several analysis methods: dipole fitting; the minimum norm estimate (MNE); beamforming; the multiple signal classification algorithm (MUSIC), including RAP-MUSIC with the RAP dilemma and TRAP-MUSIC, which removes the RAP dilemma; independent component analysis (ICA); and blind source separation (BSS) with joint diagonalization.
These twenty lectures have been developed and refined by Professor Siebert during the more than two decades he has been teaching introductory Signals and Systems courses at MIT. The lectures are designed to pursue a variety of goals in parallel: to familiarize students with the properties of a fundamental set of analytical tools; to show how these tools can be applied to help understand many important concepts and devices in modern communication and control engineering practice; to explore some of the mathematical issues behind the powers and limitations of these tools; and to begin the development of the vocabulary and grammar, common images and metaphors, of a general language of signal and system theory. Although broadly organized as a series of lectures, many more topics and examples (as well as a large set of unusual problems and laboratory exercises) are included in the book than would be presented orally. Extensive use is made throughout of knowledge acquired in early courses in elementary electrical and electronic circuits and differential equations. Contents:Review of the "classical" formulation and solution of dynamic equations for simple electrical circuits; The unilateral Laplace transform and its applications; System functions; Poles and zeros; Interconnected systems and feedback; The dynamics of feedback systems; Discrete-time signals and linear difference equations; The unilateral Z-transform and its applications; The unit-sample response and discrete-time convolution; Convolutional representations of continuous-time systems; Impulses and the superposition integral; Frequency-domain methods for general LTI systems; Fourier series; Fourier transforms and Fourier's theorem; Sampling in time and frequency; Filters, real and ideal; Duration, rise-time and bandwidth relationships: The uncertainty principle; Bandpass operations and analog communication systems; Fourier transforms in discrete-time systems; Random Signals; Modern communication systems. William Siebert is Ford Professor of Engineering at MIT. Circuits, Signals, and Systemsis included in The MIT Press Series in Electrical Engineering and Computer Science, copublished with McGraw-Hill.
This book is a self-contained introduction to the theory of signals and systems, which lies at the basis of many areas of electrical and computer engineering. In the seventy short ?glectures,?h formatted to facilitate self-learning and to provide easy reference, the book covers such topics as linear time-invariant (LTI) systems, the Fourier transform, the Laplace Transform and its application to LTI differential systems, state-space systems, the z-transform, signal analysis using MATLAB, and the application of transform techniques to communication systems. A wide array of technologies, including feedback control, analog and discrete-time fi lters, modulation, and sampling systems are discussed in connection with their basis in signals and systems theory. The accompanying CD-ROM includes applets, source code, sample examinations, and exercises with selected solutions.