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Cosmos 2229 was launched on December 29, 1992, containing a biological payload including two young male rhesus monkeys, insects, amphibians, and cell cultures. The biosatellite was launched from the Plesetsk Cosmodrome in Russia for a mission duration of 11.5 days. The major research objectives were: (1) Study of adaptive response mechanisms of mammals during flight; and (2) Study of physiological mechanisms underlying vestibular, motor system and brain function in primates during early and later adaptation phases. American scientists and their Russian collaborators conducted 11 experiments on this mission which included extensive preflight and postflight studies with rhesus monkeys. Biosamples and data were subsequently transferred to the United States. The U.S. responsibilities for this flight included the development of experiment protocols, the fabrication of some flight instrumentation and experiment-specific ground-based hardware, the conducting of preflight and postflight testing and the analysis of biospecimens and data for the U.S. experiments. A description of the Cosmos 2229 mission is presented in this report including preflight, on-orbit and postflight activities. The flight and ground-based bioinstrumentation which was developed by the U.S. and Russia is also described, along with the associated preflight testing ot the U.S. hardware. Final Science Reports for the experiments are also included. Connolly, James P. (Editor) and Skidmore, Michael G. (Editor) and Helwig, Denice A. (Editor) Ames Research Center NASA-TM-110439, NAS 1.15:110439, A-976106 RTOP 106-30-43...
Cosmos 2044 was launched on September 15, 1989, containing radiation dosimetry experiments and a biological payload including two young male rhesus monkeys, ten adult male Wistar rats, insects, amphibians, protozoa, cell cultures, worms, plants and fish. The biosatellite was launched from the Plesetsk Cosmodrome in the Soviet Union for a mission duration of 14 days, as planned. The major research objectives were: (1) Study adaptive response mechanisms of mammals during flight; (2) Study physiological mechanisms underlying vestibular, motor system and brain function in primates during early and later adaptation phases; (3) Study the tissue regeneration processes of mammals; (4) Study the development of single-celled organisms, cell cultures and embryos in microgravity; (5) Study radiation characteristics during the mission and investigate doses, fluxes and spectra of cosmic radiation for various types of shielding. American and Soviet specialists jointly conducted 29 experiments on this mission including extensive preflight and post flight studies with rhesus monkeys, and tissue processing and cell culturing post flight. Biosamples and data were subsequently transferred to the United States. The U.S. responsibilities for this flight included development of flight and ground-based hardware, the preparation of rat tissue sample procedures, the verification testing of hardware and experiment procedures, and the post flight analysis of biospecimens and data for the joint experiments. The U.S. investigations included four primate experiments, 24 rat experiments, and one radiation dosimetry experiment. Three scientists investigated tissue repair during flight for a subgroup of rats injured preflight by surgical intervention. A description of the Cosmos 2044 mission is presented in this report including preflight, on-orbit and post flight activities. The flight and ground-based bioinstrumentation which was developed by the U.S. and U.S.S.R. is also described, along with the...
Two male young-adult rhesus monkeys were flown on the Soviet Biosatellite Cosmos 1667 for seven days from July 10-17, 1985. Both animals were instrumented to record neurophysiological parameters. One animal, Gordyy, was additionally instrumented to record cardiovascular changes. Space capsule and environmental parameters were very similar to those of previous missions. On Cosmos 1514, which flew for five days in 1983, one animal was fitted with a left carotid artery cuff to measure blood pressure and flow velocity. An additional feature of Cosmos 1667 was a postflight control study using the flight animal. Intermittent postural tilt tests were also conducted before and after spaceflight and synchronous control studies, to simulate the fluid shifts associated with spaceflight. The experiment results support the conclusion derived from Cosmos 1514 that significant cardiovascular changes occur with spaceflight. The changes most clearly seen were rapid initial decreases in heart rate and further decreases with continued exposure to microgravity. The triggering mechanism appeared to be a headward shift in blood and tissue fluid volume which, in turn, triggered adaptive cardiovascular changes. Adaptive changes took place rapidly and began to stabilize after the first two days of flight. However, these changes did not plateau in the animal by the last day of the mission. Hines, John W. (Editor) and Skidmore, Michael G. (Editor) Ames Research Center CARDIOVASCULAR SYSTEM; GRAVITATIONAL EFFECTS; MICROGRAVITY; NEUROPHYSIOLOGY; PHYSIOLOGICAL RESPONSES; SPACEBORNE EXPERIMENTS; BIOSATELLITES; BLOOD PRESSURE; BLOOD VOLUME; HEART RATE; MONKEYS; SPACE FLIGHT...
NASA SP-2004-4407. NASA History Series. Edited by John M. Logsdon, et al. 6th in a series containing a selection of key documents in the history of the United States civil space program. Includes chapters on solar physics, space physics, life sciences, and Earth science. LC. card 96-9066.