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Marlitt Erbe provides a detailed introduction into the young research field of Magnetic Particle Imaging (MPI) and field free line (FFL) imaging in particular. She derives a mathematical description of magnetic field generation for FFL imaging in MPI. To substantiate the simulation studies on magnetic FFL generation with a proof-of-concept, the author introduces the FFL field demonstrator, which provides the world’s first experimentally generated rotated and translated magnetic FFL field complying with the requirements for FFL reconstruction. Furthermore, she proposes a scanner design of considerably enhanced magnetic field quality and efficiency. The author discusses the influence of magnetic field quality optimization on the image quality achieved using efficient Radon-based reconstruction methods, which arise for a line detection scheme and based on this optimized design, presents a dynamic FFL scanner assembly.
This volume provides a comprehensive overview of recent developments in magnetic particle imaging (MPI), a novel imaging modality. Using various static and oscillating magnetic fields, and tracer materials made from iron oxide nanoparticles, MPI can perform background-free measurements of the particles’ local concentration. The method exploits the nonlinear remagnetization behavior of the particles and has the potential to surpass current methods for the detection of iron oxide in terms of sensitivity and spatiotemporal resolution. Starting from an introduction to the technology, the topics addressed include setting up an imaging device, assessment of image quality, development of new MPI tracer materials, and the first preclinical results. This is the first book to be published on magnetic particle imaging, and it will be an invaluable source of information for everyone with an interest in this exciting new modality.
Nanomedicine - the application of nanotechnology to human health - is a promising field of research at the interface of physical, chemical, biological, and medical science. Recent advances have made it possible to analyze biological systems at cellular and subcellular levels, offering numerous promising approaches to improve medical diagnosis and therapy. It is expected that nanomedicine will have a great impact especially on drug delivery and imaging. In this context, the development of targeted, highly specific nanoparticles is of pivotal importance. The results of these advances will offer personalized diagnostic tools and treatments in the future. Based on the 2nd Else Kröner-Fresenius-Symposium, this book presents a broad spectrum of topics ranging from nanoscale drug delivery/drug design to nanotoxicity and from diagnostics and imaging to therapeutic applications including antibody therapies. The contributions are authored by leading experts in the field and provide an excellent overview of the current knowledge in nanomedicine. Due to the interdisciplinary nature of the subject area this volume will be of special interest to physicians, biologists, chemists, engineers, and physicists as well as to students in the respective fields.
This book describes recent collaborations combining the expertise of applied mathematicians, engineers and geophysicists within a research training group (RTG) on "Modeling, Simulation and Optimization of Fluid Dynamic Applications”, funded by the Deutsche Forschungsgemeinschaft (DFG). The focus is on mathematical modeling, adaptive discretization, approximation strategies and shape optimization with PDEs. The balanced research program is based on the guiding principle that mathematics drives applications and is inspired by applications. With this leitmotif the RTG advances research in Modeling, Simulation and Optimization by an interdisciplinary approach, i.e., to stimulate fundamental education and research by highly complex applications and at the simultaneously transfer tailored mathematical methods to applied sciences. The reported research involves nine projects and addresses challenging fluid dynamic problems inspired by applied sciences, such as climate research & meteorology, energy, aerospace & marine engineering, or medicine. More fundamental research concerning analysis, approximation and numerics is also covered. The material represents a successful attempt to exchange research paradigms between different disciplines and thus displays a modern approach to basic research into scientifically and societally relevant contemporary problems.
This book includes the original, peer-reviewed research papers from the 10th Frontier Academic Forum of Electrical Engineering (FAFEE 2022), held in Xi’an, China, in August 2022. It gathers the latest research, innovations, and applications in the fields of Electrical Engineering. The topics it covers include electrical materials and equipment, electrical energy storage and device, power electronics and drives, new energy electric power system equipment, IntelliSense and intelligent equipment, biological electromagnetism and its applications, and insulation and discharge computation for power equipment. Given its scope, the book benefits all researchers, engineers, and graduate students who want to learn about cutting-edge advances in Electrical Engineering.
The study of electromagnetic fields in the treatment of various diseases is not a new one; however, we are still learning how magnetic fields impact the human body and its organs. Many novel magnetic materials and technologies could potentially transform medicine. Magnetic Materials and Technologies for Medical Applications explores these current and emerging technologies. Beginning with foundational knowledge on the basics of magnetism, this book then details the approaches and methods used in the creation of novel magnetic materials and devices. This book also discusses current technologies and applications, as well as the commercial aspects of introducing new technologies to the field. This book serves as an excellent introduction for early career researchers or a reference to more experienced researchers who wish to stay abreast of current trends and developing technologies in the field. This book could also be used by clinicians working in medicine and companies interested in establishing new medical technologies. Each chapter provides novel tasks for future scientific and technology research studies. - Outlines the basics of magnetism for enhanced understanding of its applications in medicine - Covers novel magnetic devices as well as technologies still under development, including magnetic brain stimulation, biosensors, and nanoparticles for drug delivery - Explores commercial opportunities and obstacles to market entry for new magnetic materials and technologies for the medical field
This first book to focus on the applications of nanomagnetism presents those already realized while also suggesting bold ideas for further breakthroughs. The first part is devoted to the concept of spin electronics and its use for data storage and magnetic sensing, while the second part concentrates on magnetic nanoparticles and their use in industrial environment, biological and medical applications. The third, more prospective part goes on to describe emerging applications related to spin current creation and manipulation, dynamics, spin waves and binary logic based on nano-scale magnetism. With its unique choice of topics and authors, this will appeal to academic as well as corporate researchers in a wide range of disciplines from physics via materials science to engineering, chemistry and life science.
Precision Medicine: Tools and Quantitative Approaches discusses precision and personalized medicine, two relevant topics that are revolutionizing diagnostics and treatment, while also providing a shift toward prevention. The book covers the most relevant features and explanations underlying developments in the field. A timely review on prerequisites, causes and consequences is given. Unique to this book is a combined view on technical and data analysis aspects that is mandatory for obtaining and interpreting results. This book is a valuable source for researchers in medical and life sciences, physicians and students with an interest in this emerging field of precision medicine. - Provides technological aspects in precision medicine with aspects of modern statistical and bioinformatics models and methods - Brings timely reviews on status and chances in precision medicine and associated aspects of data analysis, statistics and data interpretation - Encompasses easy access to relevant approaches, interactions and original literature
Magnetic Particle Imaging (MPI) is a novel imaging modality. In MPI superparamagnetic iron oxide nanoparticles are used as tracer materials. The volume is the proceeding of the 2nd international workshop on magnetic particle imaging (IWMPI). The workshop aims at covering the status and recent developments of both, the instrumentation and the tracer material, as each of them is equally important in designing a well performing MPI. For instance, the current state of the art in magnetic coil design for MPI is discussed. With a new symmetrical arrangement of coils, a field-free line (FFL) can be produced that promises a significantly higher sensitivity compared with the standard arrangement for a FFP. Furthermore, the workshop aims at presenting results from phantom and pre-clinical studies.
This book constitutes the refereed proceedings of the 5th International Workshop on Machine Learning for Medical Reconstruction, MLMIR 2022, held in conjunction with MICCAI 2022, in September 2022, held in Singapore. The 15 papers presented were carefully reviewed and selected from 19 submissions. The papers are organized in the following topical sections: deep learning for magnetic resonance imaging and deep learning for general image reconstruction.