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Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.
First multi-year cumulation covers six years: 1965-70.
The first guide to compile current research and frontline developments in the science of process intensification (PI), Re-Engineering the Chemical Processing Plant illustrates the design, integration, and application of PI principles and structures for the development and optimization of chemical and industrial plants. This volume updates professionals on emerging PI equipment and methodologies to promote technological advances and operational efficacy in chemical, biochemical, and engineering environments and presents clear examples illustrating the implementation and application of specific process-intensifying equipment and methods in various commercial arenas.
This book is a hard bound edition of a special issue (vol. 48/20-22) of the journal Electrochimica Acta. It summarizes the highlights of the 53rd Annual meeting of the International Society of Electrochemistry and Annual meeting of the GDCh-Fachgruppe Angewandte Elektrochemie. The theme of the conference was Electrochemistry in Molecular and Microscopic dimensions and was based on the role of electrochemistry in the miniaturization of chemical and physical methods. Topics covered are : - development of electrochemistry with microscopic and molecular resolution; - initiation of advances in Electrochemical Microsystem Technologies EMT, and micro/nano-electronics; - development of Electrochemical Materials Science for nanomaterials; - enhancement of miniaturization and sensitivity of electroanalysis, and; - the bridge from electrochemistry to biology and medicine of microscopic and molecular understanding. - Summarizes the highlights of two major electrochemistry meetings. - It includes research papers on the electrochemical processes in micro- and nanotechnology. - Highlights developments and advances in electrochemistry.
Solid Liquid Separation includes important industrial processes used for recovery and processing of solids or purification of liquids. Most of the process industries in which particulate slurries are handled use some form of solid-liquid separation and yet the subject is not adequately covered in most higher education courses. This book is designed to bring the readers up-to-date on the principles and industrial practices of solid-liquid separation and washing technology. Particular attention is given to hardware and to its evaluation, application and selection. Whilst not exclusively concerned with filtration and sedimentation, these operations will be dealt with in depth. Important variations in the available equipment will be discussed throughout the book with emphasis on basic engineering concepts, equipment selection and evaluation, solids washing, methods of pre-treatment, filter aids and other practical aspects of mechanical separation. This book is intended for engineers and scientists of graduate status who are engaged in design, production for research and development. This book is designed to bring the readers up-to-date on the principles and industrial practices of solid-liquid separation and washing technology. Particular attention is given to hardware and to its evaluation, application and selection. Whilst not exclusively concerned with filtration and sedimentation, these operations are dealt with in depth. Important variations in the available equipment are discussed throughout the book with emphasis on basic engineering concepts, equipment selection and evaluation, solids washing, methods of pre-treatment, filter aids and other practical aspects of mechanical separation. This book is intended for engineers and scientists of graduate status who are engaged in design, production for research and development. - Author is the top of his field, and knows well all the latest advances in his subject area - Fourth edition of a title which is respected and admired in the world of Chemical Engineering - Updated and revised to match the developments in the industry
The importance of molecular recognition in chemistry and biology is reflected in a recent upsurge in relevant research, promoted in particular by high-profile initiatives in this area in Europe, the USA and Japan. Although molecular recognition is necessarily microscopic in origin, its consequences are de facto macroscopic. Accordingly, a text that starts with intermolecular interactions between simple molecules and builds to a discussion of molecular recognition involving larger scale systems is timely. This book was planned with such a development in mind. The book begins with an elementary but rigorous account of the various types of forces between molecules. Chapter 2 is concerned with the hydrogen bond between pairs of simple molecules in the gas phase, with particular reference to the preferred relative orientation of the pair and the ease with which this can be distorted. This microscopic view continues in chapter 3 wherein the nature of interactions between solute molecules and solvents or between two or more solutes is examined from the experimental standpoint, with various types of spectroscopy providing the probe of the nature of the interactions. Molecular recognition is central to the catalysis of chemical reactions, especially when bonds are to be broken and formed under the severe con straint that a specific configuration is to result, as in the production of enan tiotopically pure compounds. This important topic is considered in chapter 4.
Green Chemistry has brought about dramatic changes in the teaching of chemistry that have resulted in increased student excitement for the subject of chemistry, new lecture materials, new laboratory experiments, and a world-wide community of Green Chemistry teachers. This book features the cutting edge of this advance in the teaching of chemistry.