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"This is the colorful and dramatic biography of two of America's most controversial entrepreneurs: Moses Louis Annenberg, 'the racing wire king, ' who built his fortune in racketeering, invested it in publishing, and lost much of it in the biggest tax evasion case in United States history; and his son, Walter, launcher of TV Guide and Seventeen magazines and former ambassador to Great Britain."--Jacket.
The rise of bio- and nano-technology in the last decades has led to the emergence of a new and unique type of medicine known as non-biological complex drugs (NBCDs). This book illustrates the challenges associated with NBCD development, as well as the complexity of assessing the effects of manufacturing changes on innovator and follow-on batches of NBCDs. It also touches upon proven marketing authorization requirements for biosimilars that could be effective in evaluating follow-on NBCDs, including a demonstration of control over the manufacturing process and a need for detailed physico-chemical characterization and (pre)clinical tests. This book is meant to be used for years to come as a standard reference work for the development of NBCDs. Moreover, this book aims to stimulate discussions and further our thinking to ensure that decisions regarding the approval of complex drugs are made with relevant scientific data on the table.
Many novels revolve round the figure of Jesus. Some of the finest of them are defined by Ziolkowski as fictional transfigurations of Jesus. They share a modern hero patterned on Jesus the culture-hero, whose life consisted of the motifs of the last supper, lonely agony, betrayal, trial, and crucifixion. The aesthetic challenge of adapting this most familiar story for their generation has attracted an unusual number of great writers, among them Papini, Kazantzakis, Hesse, Mann, Greene, Faulkner, and Gore Vidal. The form began with the new image of a humanized Jesus which developed in the 19th century. The interest in religious paranoia and hysteria at the turn of the century instantly expanded its potentialities as novelists began to explore the theme of christomania. This was followed by studies of Jesus as a mythic figure and then Marxist-oriented portraits of Comrade Jesus. Finally the form became inverted into parody in the Fifth Gospels in which not Jesus, but Judas, is the central figure.
Describes Dostoevsky's early years "from his boyhood and the death of his father through his years at the engineering academy in St. Petersburg, his brief career as a government draughtsman, and his involvement with Petrashevsky's radical group that led to exile in Siberia." -- Dust jacket.
This forward-looking book focuses on the recent advances in nanomedicine and drug delivery. It outlines the extraordinary new tools that have become available in nanomedicine and presents an integrated set of perspectives that describe where we are now and where we should be headed to put nanomedicine devices into applications as quickly as possible, while also considering the possible dangers of nanomedicine. The book considers the full range of nanomedicinal applications that employ molecular nanotechnology inside the human body, from the perspective of a future practitioner in an era of widely available nanomedicine. Written by some of the most innnovative minds in medicine and engineering, this unique volume will help professionals understand cutting-edge and futuristic areas of research that can have tremendous payoff in terms of improving human health. Readers will find insightful discussions of nanostructured intelligent materials and devices that are considered technically feasible and which have a high potential to produce advances in medicine in the near future. Topics include: Health benefits of phytochemicals and the application of colloidal delivery systems Study of non-covalent attachment of recombinant targeting proteins to polymer-modified Adenoviral gene delivery vectors The role of nanoparticles as adjuvants for mucosal vaccine delivery Poly(amido-amine)s as delivery styems for biologically active substances Antimicrobial activity of silver nanoparticles Nanomedicine in the use of cancer treatment Dendrimers, capsules based on lipid vesicles for drug delivery Many other recent achievements