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If you are new to survival analysis or want to expand your capabilities in this area, you'll benefit from Alan Cantor's SAS Survival Analysis Techniques for Medical Research, Second Edition, which presents the theory and methods of survival analysis along with excellent discussions of the SAS procedures used to implement the methods described. New features of the second edition include a discussion of permutation and randomization tests; a discussion of the use of data imputation; an expanded discussion of power for Cox regression; descriptions of the new features of SAS 9, such as confidence bands for the Kaplan-Meier curve; appendixes that cover mathematical and statistical background topics needed in survival analysis; and student exercises. The new features, along with several useful macros and numerous examples, make this a suitable textbook for a course in survival analysis for biostatistics majors and majors in related fields. This book excels at presenting complex ideas in a way that enables those without a strong technical background to understand and apply the concepts and techniques.
This book is for statistical practitioners, particularly those who design and analyze studies for survival and event history data. Building on recent developments motivated by counting process and martingale theory, it shows the reader how to extend the Cox model to analyze multiple/correlated event data using marginal and random effects. The focus is on actual data examples, the analysis and interpretation of results, and computation. The book shows how these new methods can be implemented in SAS and S-Plus, including computer code, worked examples, and data sets.
Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with time-to-event endpoints are often limited to the exponential model or proportional hazards model. In practice, however, those model assumptions may not be satisfied for long-term survival trials. This book is the first to cover comprehensively the many newly developed methodologies for survival trial design, including trial design under the Weibull survival models; extensions of the sample size calculations under the proportional hazard models; and trial design under mixture cure models, complex survival models, Cox regression models, and competing-risk models. A general sequential procedure based on the sequential conditional probability ratio test is also implemented for survival trial monitoring. All methodologies are presented with sufficient detail for interested researchers or graduate students.
Analysis of Clinical Trials Using SAS®: A Practical Guide, Second Edition bridges the gap between modern statistical methodology and real-world clinical trial applications. Tutorial material and step-by-step instructions illustrated with examples from actual trials serve to define relevant statistical approaches, describe their clinical trial applications, and implement the approaches rapidly and efficiently using the power of SAS. Topics reflect the International Conference on Harmonization (ICH) guidelines for the pharmaceutical industry and address important statistical problems encountered in clinical trials. Commonly used methods are covered, including dose-escalation and dose-finding methods that are applied in Phase I and Phase II clinical trials, as well as important trial designs and analysis strategies that are employed in Phase II and Phase III clinical trials, such as multiplicity adjustment, data monitoring, and methods for handling incomplete data. This book also features recommendations from clinical trial experts and a discussion of relevant regulatory guidelines. This new edition includes more examples and case studies, new approaches for addressing statistical problems, and the following new technological updates: SAS procedures used in group sequential trials (PROC SEQDESIGN and PROC SEQTEST) SAS procedures used in repeated measures analysis (PROC GLIMMIX and PROC GEE) macros for implementing a broad range of randomization-based methods in clinical trials, performing complex multiplicity adjustments, and investigating the design and analysis of early phase trials (Phase I dose-escalation trials and Phase II dose-finding trials) Clinical statisticians, research scientists, and graduate students in biostatistics will greatly benefit from the decades of clinical research experience and the ready-to-use SAS macros compiled in this book.
Second Edition SAS® PROGRAMMING FOR RESEARCHERS AND SOCIAL SCIENTISTS By PAUL E. SPECTOR, University of South Florida University of South Florida "Just what the novice SAS programmer needs, particularly those who have no real programming experience. For example, branching is one of the more difficult programming commands for students to implement and the author does an excellent job of explaining this topic clearly and at a basic level. A big plus is the Common Errors section since students will definitely encounter errors." a?Robert Pavur, Management Science, University of North Texas The book that won accolades from thousands has been completely revised! Taking a problem solving approach that focuses on common programming tasks that social scientists encounter in doing data analysis, Spector uses sample programs and examples from social science problems to show readers how to write orderly programs and avoid excessive and disorganized branching. He provides readers with a three-step approach (preplanning, writing the program, and debugging) and tips about helpful features and practices as well as how to avoid certain pitfalls. "Spector has done an excellent job in explaining a somewhat difficult topic in a clear and concise manner. I like the fact that screen captures are included. It allows students to better follow what is being described in the book in relation to what is on the screen." a?Philip Craiger, Computer Science, University of Nebraska, Omaha ThisA bookA provides readers with even more practical tips and advice. New features in this edition include: *New sections on debugging in each chapter that provide advice about common errors *End of chapter Debugging Exercises that offer readers the chance to practice spotting the errors in the sample programs *New section in Chapter 1 on how to use the interface, including how to work with three separate windows, where to write the program, executing the program, managing the program files, and using the F key *Five new appendices, including a Glossary of Programming Terms, A Summary of SAS Language Statements, A Summary of SAS PROCs, Information Sources for SAS PROCs, and Corrections for the Debugging Exercises *Plus, a link to Spector's online SAS course! Appropriate for readers with little or no knowledge of the SAS language, this book will enable readers to run each example, adapt the examples to real problems that the reader may have, and create a program. "A solid introduction to programming in SAS, with a good, brief explanation of how that process differs from the usual point-and-click of Windows-based software such as SPSS and a spreadsheet. Even uninformed students can use it as a guide to creating SAS datasets, manipulating them, and writing programs in the SAS language that will produce all manner of statistical results." a?James P. Whittenburg, History, College of William & Mary A "Bridges the gap between programming syntax and programming applications. In contrast to other books on SAS programming, this book combines a clear explanation of the SAS language with a problem-solving approach to writing a SAS program. It provides the novice programmer with a useful and meaningful model for solving the types of programming problems encountered by re
Making complex methods more accessible to applied researchers without an advanced mathematical background, the authors present the essence of new techniques available, as well as classical techniques, and apply them to data. Practical suggestions for implementing the various methods are set off in a series of practical notes at the end of each section, while technical details of the derivation of the techniques are sketched in the technical notes. This book will thus be useful for investigators who need to analyse censored or truncated life time data, and as a textbook for a graduate course in survival analysis, the only prerequisite being a standard course in statistical methodology.
Using time-to-event analysis methodology requires careful definition of the event, censored observation, provision of adequate follow-up, number of events, and independence or "noninformativeness" of the censoring mechanisms relative to the event. Design and Analysis of Clinical Trials with Time-to-Event Endpoints provides a thorough presentation o
Features and capabilities of the REG, ANOVA, and GLM procedures are included in this introduction to analysing linear models with the SAS System. This guide shows how to apply the appropriate procedure to data analysis problems and understand PROC GLM output. Other helpful guidelines and discussions cover the following significant areas: Multivariate linear models; lack-of-fit analysis; covariance and heterogeneity of slopes; a classification with both crossed and nested effects; and analysis of variance for balanced data. This fourth edition includes updated examples, new software-related features, and new material, including a chapter on generalised linear models. Version 8 of the SAS System was used to run the SAS code examples in the book. * Provides clear explanations of how to use SAS to analyse linear models * Includes numerous SAS outputs * Includes new chapter on generalised linear models * Uses version 8 of the SAS system This book assists data analysts who use SAS/STAT software to analyse data using regression analysis and analysis of variance. It assumes familiarity with basic SAS concepts such as creating SAS data sets with the DATA step and manipulating SAS data sets with the procedures in base SAS software.
SAS® System for Regression Learn to perform a wide variety of regression analyses using SAS® software with this example-driven revised favorite from SAS Publishing. With this Third Edition you will learn the basics of performing regression analyses using a wide variety of models including nonlinear models. Other topics covered include performing linear regression analyses using PROC REG diagnosing and providing remedies for data problems, including outliers and multicollinearity. Examples feature numerous SAS procedures including REG, PLOT, GPLOT, NLIN, RSREG, AUTOREG, PRINCOMP, and others. A helpful discussion of theory is supplied where necessary. Some knowledge of both regression and the SAS System are assumed. New for this edition The Third Edition includes revisions, updated material, and new material. You’ll find new information on using SAS/INSIGHT® software regression with a binary response with emphasis on PROC LOGISTIC nonparametric regression (smoothing) using moving averages and PROC LOESS. Additionally, updated material throughout the book includes high-resolution PROC REG graphics output, using the OUTEST option to produce a data set, and using PROC SCORE to predict another data set.