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Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization. - Winner of the 2017 PROSE Award in Biomedicine & Neuroscience and the 2017 British Medical Association (BMA) Award in Neurology - Extensively illustrated throughout by graphical representations of key mathematical concepts and their practical applications to analyses of nervous systems - Comprehensively covers graph theoretical analyses of structural and functional brain networks, from microscopic to macroscopic scales, using examples based on a wide variety of experimental methods in neuroscience - Designed to inform and empower scientists at all levels of experience, and from any specialist background, wanting to use modern methods of network science to understand the organization of the brain
The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Notable experts in the field of neuroimaging provide comprehensive overviews of advances in functional and structural aspects of both common and uncommon brain disorders. Functional imaging is evolving quickly but researchers and clinicians do not always have a strong understanding of the fundamental basis of the imaging techniques that they use. By focusing on both structure and function this book will provide a strong foundation for emerging developments in the field.
This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
A systematic, innovative introduction to the field of network analysis, Network Psychometrics with R: A Guide for Behavioral and Social Scientists provides a comprehensive overview of and guide to both the theoretical foundations of network psychometrics as well as modelling techniques developed from this perspective. Written by pioneers in the field, this textbook showcases cutting-edge methods in an easily accessible format, accompanied by problem sets and code. After working through this book, readers will be able to understand the theoretical foundations behind network modelling, infer network topology, and estimate network parameters from different sources of data. This book features an introduction on the statistical programming language R that guides readers on how to analyse network structures and their stability using R. While Network Psychometrics with R is written in the context of social and behavioral science, the methods introduced in this book are widely applicable to data sets from related fields of study. Additionally, while the text is written in a non-technical manner, technical content is highlighted in textboxes for the interested reader. Network Psychometrics with R is ideal for instructors and students of undergraduate and graduate level courses and workshops in the field of network psychometrics as well as established researchers looking to master new methods. This book is accompanied by a companion website with resources for both students and lecturers.
The conscious mind defines human existence. Many consider the brain as a computer, and they attempt to explain consciousness as emerging at a critical, but unspecified, threshold level of complex computation among neurons. The brain-as-computer model, however, fails to account for phenomenal experience and portrays consciousness as an impotent, after-the-fact epiphenomenon lacking causal power. And the brain-as-computer concept precludes even the remotest possibility of spirituality. As described throughout the history of humankind, seemingly spiritual mental phenomena including transcendent states, near-death and out-of-body experiences, and past-life memories have in recent years been well documented and treated scientifically. In addition, the brain-as-computer approach has been challenged by advocates of quantum brain biology, who are possibly able to explain, scientifically, nonlocal, seemingly spiritual mental states. Exploring Frontiers of the Mind-Brain Relationship argues against the purely physical analysis of consciousness and for a balanced psychobiological approach. This thought-provoking volume bridges philosophy of mind with science of mind to look empirically at transcendent phenomena, such as mystic states, near-death experiences and past-life memories, that have confounded scientists for decades. Representing disciplines ranging from philosophy and history to neuroimaging and physics, and boasting a panel of expert scientists and physicians, including Andrew Newberg, Peter Fenwick, Stuart Hameroff, Mario Beauregard, Deepak Chopra, and Chris Clarke the book rigorously follows several lines of inquiry into mind-brain controversies, challenging readers to form their own conclusions—or reconsider previous ones. Key coverage includes: Objections to reductionistic materialism from the philosophical and the scientific tradition. Phenomena and the mind-brain problem. The neurobiological correlates of meditation and mindfulness. The quantum soul, a view from physics. Clinical implications of end-of-life experiences. Mediumistic experience and the mind-brain relationship. Exploring Frontiers of the Mind-Brain Relationship is essential reading for researchers and clinicians across many disciplines, including cognitive psychology, personality and social psychology, the neurosciences, neuropsychiatry, palliative care, philosophy, and quantum physics. “This book ... brings together some precious observations about the fundamental mystery of the nature of consciousness ... It raises many questions that serve to invite each of us to be more aware of the uncertainty of our preconceptions about consciousness ... This book on the frontiers of mind-body relationships is a scholarly embodiment of creative and open-minded science.” C. Robert Cloninger, MD Wallace Renard Professor of Psychiatry, Genetics, and Psychology, Washington University School of Medicine St. Louis MO
Experimental and theoretical approaches to global brain dynamics that draw on the latest research in the field. The consideration of time or dynamics is fundamental for all aspects of mental activity—perception, cognition, and emotion—because the main feature of brain activity is the continuous change of the underlying brain states even in a constant environment. The application of nonlinear dynamics to the study of brain activity began to flourish in the 1990s when combined with empirical observations from modern morphological and physiological observations. This book offers perspectives on brain dynamics that draw on the latest advances in research in the field. It includes contributions from both theoreticians and experimentalists, offering an eclectic treatment of fundamental issues. Topics addressed range from experimental and computational approaches to transient brain dynamics to the free-energy principle as a global brain theory. The book concludes with a short but rigorous guide to modern nonlinear dynamics and their application to neural dynamics.
An integrative overview of network approaches to neuroscience explores the origins of brain complexity and the link between brain structure and function. Over the last decade, the study of complex networks has expanded across diverse scientific fields. Increasingly, science is concerned with the structure, behavior, and evolution of complex systems ranging from cells to ecosystems. In Networks of the Brain, Olaf Sporns describes how the integrative nature of brain function can be illuminated from a complex network perspective. Highlighting the many emerging points of contact between neuroscience and network science, the book serves to introduce network theory to neuroscientists and neuroscience to those working on theoretical network models. Sporns emphasizes how networks connect levels of organization in the brain and how they link structure to function, offering an informal and nonmathematical treatment of the subject. Networks of the Brain provides a synthesis of the sciences of complex networks and the brain that will be an essential foundation for future research.
The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience addresses “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspectives.