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In this thesis the literature about the pathogenesis of atherosclerosis has been reviewed. The various risk indicators for atherosclerosis are discussed and related to the theory about atherogenesis. A review of the influence of milk fat constituents and dietary proteins on serum lipids and atherosclerosis is presented. Experimental results obtained with rabbits fed on semi-synthetic diets are reported. It is shown that large amounts of butyric acid have the same effect on blood, liver and tissue lipids and fatty acids as starch. Hypercholesterolemic affects of butter oil can be mainly ascribed to its cholesterol content. The hypercholesterolemic effects of semi-synthetic diets containing saturated fats can be mainly ascribed to the use of casein as protein source. The hypercholesterolemia induced by semisynthetic diets is shown to be the consequence of decreased faecal steroid excretion. It is suggested that the different serum cholesterol levels induced by various dietary proteins are due to a redistribution of serum cholesterol to other body compartments.
Dietary Proteins and Atherosclerosis provides a thorough review of the role of proteins in the development of atherosclerosis. The author reviews early research connections between dietary fat and cardiovascular disease caused by the build-up of plaque in arteries and examines other factors that contribute to atherosclerosis, such as infection and
This book examines several recent, major developments in the field of nutritional pathology, providing enhanced, current understanding of the role that altered or disturbed nutrition plays in the pathogenesis of disease. It is intended for students in pathology, nutrition, and biochemistry.
Protides of the Biological Fluids: Proceedings of the 25th Colloquium, Brugge, 1977 focuses on the structure, metabolism, transformations, and reactions of protides of biological fluids. The selection first takes a look at the structure and metabolism of plasma lipoproteins, including phosphatidylinositol exchange protein from bovine brain; structural integrity of the mitochondrial adenine nucleotide carrier; and reassembly of the monosaccharide transport system of the human erythrocyte in black lipid membranes. The book then discusses species and dietary effects on lipoprotein apoprotein metabolism in vivo; transfer of surface and core lipids of a lipoprotein from plasma into aortic wall; and pathophysiological implications of hyperlipoproteinemia. The text focuses on lipoproteins of human peripheral lymph, portacaval shunt and lipid metabolism, and low density lipoprotein catabolism in the liver. The methods and results of experiments are presented. The book also discusses the effects of dietary cholesterol on serum lipoprotein in human; long-term effects of physical training on blood lipids and lipoproteins in primary hyperlipoproteinemia; and effects of clofibrate on plasma proteins in subjects with hypertriglyceridemia. The selection is a vital source of data for readers wanting to study the protides of biological fluids.
Analyzes the effects of dietary animal, vegetable and fish proteins on serum cholesterol levels in animal models and humans. Explores the possible mechanisms which have been advanced to date and reports the results of original research inquiries.