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Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology. The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin. Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.
Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the gap between the moisturizers and the skin by covering all the essential information required to tailor the use of moisturizers to particular disorders and patients. Important aspects of skin biochemistry and barrier function are explained, and the ingredients and treatment effects of moisturizers are explored in depth. Careful attention is paid to controversies, including the role of certain moisturizers in inducing dryness/eczema, asthma, and comedones. The information provided in this unique book will enable the reader to go beyond the traditional thinking regarding skin care. The novel insights offered will suggest the properties required for a new generation of moisturizing treatments that more effectively improve the quality of life.
Measuring the Skin presents all techniques devoted to non-invasive normal or diseased skin measurement. As opposed other books, this text embraces old and new validated techniques for all skin suborgans and functions. The book is ideal as a small encyclopedia since it provides the answer to any question concerning skin measurement. Each technique is discussed to help select the most appropriate one for each special case. Another novel feature is that the book bases the skin investigation on the physiology and anatomy. Each chapter is preceded by a compendium of current knowledge on the structure or function dealt with. The book may also be used as a research tool. It contains a novel, and presently unique list of more than 400 physical and biological skin constants, which are all referenced.
Since extensive dermatoses can be life threatening, it is important to recognize and treat skin emergencies rapidly. This book covers all cutaneous emergencies and life threatening dermatoses, as well as true and false emergencies in the dermatologic office. It provides treatment advice for the management of major life threatening dermatoses, such as severe infections, severe drug eruptions and bullous diseases. In addition, it describes the manifestations in acutely ill patients in the ICU, as well as severe cutaneous manifestations occurring during pregnancy, after sun exposure, in cold weather, as a result of extreme poverty, and in other situations. With diagnostic clues, reader-friendly charts and clinical photographs, this clinical guide will not only benefit the hospital-based dermatologist, but will also be a helpful guide for non-dermatologists, such as ER and ICU physicians.
Global movement of people leads to the global movement of disease International travel enables skin diseases to move around the world with increasing ease. Skin diseases transmitted through casual contact with people, animal vectors and a foreign environment are particularly prone to transport. Dermatologists need to recognize the signs and symptoms of disease not native to their environment to enable proper diagnosis and care. Imported Skin Diseases provides a clinical guide to the foreign diseases increasingly seen in ‘Western’ clinics. With a focus on accurate diagnosis and effective therapy, the book covers: Differences between pigmented and non-pigmented skin Viral, bacterial and fungal Infections Parasitic infestations Sexually transmitted diseases Aquatic diseases Written by an international team of experts, with practical tips throughout, Imported Skin Diseases prepares you for the unusual skin diseases you are increasingly likely to see in your clinic.
Revised and expanded, this edition provides comprehensive coverage of occupational health and safety. A new CD-ROM version is available which provides the benefits of computer-assisted search capabilities
This book discusses new applications of technologies that have been or could be successfully employed to estimate the age of fingermarks. Determining the specific time a fingermark is deposited could become a powerful new development in forensic science and a useful application to law enforcement. This book aims to shed some light on this important and still controversial area of scientific research. The expert chapters review recent discoveries and current developments with a practical bent, focusing on prospective uses in real-world crime scenes. They take a multidisciplinary approach, featuring contributors with diverse specialties including Chemistry, Imaging Technologies, Forensic Science, Biology and Microbiology. The balanced presentation incorporates critiques on fingermark aging studies, explores the reliability of fingermarks as evidence, and discusses how the estimation of “age” can improve robustness of crime evidence. Each chapter describes a unique aspect of fingermark aging observed from a different analytical perspective: 2D imaging; 3D imaging; chemical analysis; chemical imaging; microbiome analysis; electrochemical analysis; and DNA analysis, as well as the role and application of statistics. Illustrations and graphs aid the reader in understanding the concepts being explained. Not just a compilation of techniques and methods, this book’s emphasis on practical applications and its easy-to-read style will appeal to a broad audience of scientists and criminal justice professionals alike. It will be of great interest to law enforcement, academia, and the criminal justice community; including forensic scientists, investigators, lawyers, students, and researchers. It aims to help facilitate debates in the broader community about the feasibility, convenience, and relevance of estimating the age of evidence.
Volume 2 is arranged alphabetically by periodical title, rather than by abbreviation.
Current Clinical Medicine's 2nd edition, by the world famous Cleveland Clinic, is an Internal Medicine reference that gives you authoritative and actionable information wherever you are, whenever you need it. More than 40 updated chapters, 13 new chapters, and 30% new illustrations ensure that you’ll have access to the most up-to-date guidance. In addition to its user-friendly, easy-access format and consistent, reliable coverage, this Expert Consult title includes a website with the complete contents of the book, fully searchable, downloadable images, and more, to keep you and your practice completely current. Includes access to a website featuring the complete contents of the book, fully searchable, access to patient information sheets, links to the Gold Standard Drug database, and much more, to keep you completely current. Provides consistent, reliable coverage to keep you on the top of your game. Includes summary boxes and algorithms for quick, confident diagnosis and treatment of each condition. Features a user-friendly format so you can find information quickly and easily. Contains more than a hundred full-color illustrations with a special focus on dermatology for highly visual guidance. Uses evidence-based gradings to help you evaluate your diagnoses. Includes many new chapters—including Hepatocellular Carcinoma, Head and Neck Cancer, Takayasu's Arteritis, and Non-Hodgkin and Hodgkin Lymphoma—as well as more than 40 substantially revised chapters, that ensure that you’ll have access to the most current coverage. Features 30% new illustrations that provide you with updated details, concepts, and procedures.
2017 PROSE Award Winner - Multivolume Reference/Science The world's number 1 dermatology information resource Universally respected, Rook's Textbook of Dermatology is the most comprehensive, definitive and best-illustrated reference work for dermatologists of all levels worldwide and has been at the forefront of international dermatology publishing since first appearing in 1968. The Ninth Edition has been radically re-engineered to match the modern day challenges faced by dermatologists. Once again it has been published as a combined digital and print resource, but with a new online platform enabling easier and faster navigation. A common structure to describe and discuss each disorder has been adopted throughout, whilst maintaining the depth of information for which Rook is renowned. A high priority has been placed on the ease of extracting key information quickly: diagnostic algorithms and management ladders help the reader choose appropriate treatment strategies. More images than ever – over 5000 in total – aid diagnosis by displaying variations in disease manifestations according to body location, skin type and severity. The section on aesthetic dermatology has been greatly expanded with more coverage of procedures in this rapidly developing field. Rook's Textbook of Dermatology, Ninth Edition provides you with: The very best content from the number one brand in dermatology – an essential consultation tool for all dermatologists An outstanding combined digital/print resource, exhaustively covering every dermatological disorder A complete overhaul of its content – each disorder now follows a consistent templated approach A fresh approach to the classification of disorders and organization of chapters, of which there are now 160 instead of 80, all organised into 14 logical sections A newly designed sophisticated online platform with a fast and powerful digital search functionality – search by keyword, disorder or chapter or consult the online image database and get expert clinical advice more quickly than ever Lavishly illustrated chapters with over 5000 colour images showing variation in disease patterns by body location, skin type and severity Comprehensive coverage of medical, surgical and aesthetic dermatology, as well as the basic science underpinning the field An experienced British editorial team working with distinguished international authors and associate editor Greater emphasis than before on clinical studies/trials, society guidelines and the latest ICD codes While key references remain in the printed version, thousands more are cited in the book and can be accessed online, where each is hyperlinked to the relevant text Rook’s Textbook of Dermatology, Ninth Edition is the complete dermatology reference work. More comprehensive than ever, with more images, more disorders covered and faster, more dynamic and wider digital search functionality. It is an essential resource for the modern day dermatologist, whether experienced or at the beginning of a career in dermatology.