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On behalf of the Scientific Program Committee, Officers and Council of the Society, I want to thank the Office of Naval Research for the Support of Symposia and Awards at the Twenty-Third Annual Conference on Shock, June 3-9, 2000, Snowbird, Utah and the Eighth International Cytokine Conference, November 5-9, 2000, RAI, Amsterdam. I am enclosing a copy of SHOCK Volume 13, 2000 supplement which contains the program and abstracts (pages 1- 68) for the Shock Conference. A summary of the meeting is also enclosed.
Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy.They act in a complex network where one cytokine can influence the production of, and response to, many other cytokines. In the past five years, this bewildering array of more than 100 effector molecules and associated cell surface receptors has been simplified by study of cytokine and cytokinereceptor structure; elucidation of convergent intracellular signalling pathways; and molecular genetics, and targeted gene disruption to 'knock-out' production of individual cytokines in mice. It is also now clear that the pathophysiology of infectious, autoimmune and malignant disease can bepartially explained by the induction of cytokines and the subsequent cellular response. Viral homologues exist for many cytokines and receptors and genetic variations in cytokine production may influence response to pathogenic stimuli. Cytokine and cytokine antagonists have shown therapeuticpotential in a number of chronic and acute diseases. The Cytokine Network: Frontiers in Molecular Biology is not a survey of individual cytokines, but guides the reader through the latest research on the cytokine network as a whole covering genomics, signalling pathways, control of the immuneresponse, and therapeutics.
The Scientific Meeting, consisting of ten symposia, sixteen workshops, three poster sessions, a presidential address, a keynote address, an award lecture and a student award session was held in Dublin, Ireland, September 20-24,2003. The scientific program Committee consisted of Luke O'Neill, chair, Andrew Bowie, Fionnuala Brennan, Charles Dinarello, Brian Foxwell, Andy Gearing, Pietro Ghezzi, Jim Johnston, Dermot Kelleher, Kingston Mills, Paul Moynagh, Anne O'Garra, Joe Oppenheim, Jeremy Saklatvala, John Sims, and Clair Gardiner. Progress in the vital area of cytokines was described by major investigators in both basic science and clinical applications. Detailed summaries of these advances are discussed in the attached proceedings of the meeting. It was a very successful meeting.