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This thoroughly updated Second Edition of Clinical Laboratory Medicine provides the most complete, current, and clinically oriented information in the field. The text features over 70 chapters--seven new to this edition, including medical laboratory ethics, point-of-care testing, bone marrow transplantation, and specimen testing--providing comprehensive coverage of contemporary laboratory medicine. Sections on molecular diagnostics, cytogenetics, and laboratory management plus the emphasis on interpretation and clinical significance of laboratory tests (why a test or series of tests is being done and what the results mean for the patient) make this a valuable resource for practicing pathologists, residents, fellows, and laboratorians. Includes over 800 illustrations, 353 in full color and 270 new to this edition. Includes a Self-Assessment and Review book.
The National Institutes of Health and the National Science Foundation together fund more than $40 billon of research annually in the United States and around the globe. These large public expenditures come with strings, including a complex set of laws and guidelines that regulate how scientists may use NIH and NSF funds, how federally funded research may be conducted, and who may have access to or own the product of the research. Until now, researchers have had little instruction on the nature of these laws and how they work. But now, with Robert P. Charrow’s Law in the Laboratory, they have a readable and entertaining introduction to the major ethical and legal considerations pertaining to research under the aegis of federal science funding. For any academic whose position is grant funded, or for any faculty involved in securing grants, this book will be an essential reference manual. And for those who want to learn how federal legislation and regulations affect laboratory research, Charrow’s primer will shed light on the often obscured intersection of government and science.

The Belmont Report

United States. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research

Published: 1978

Total Pages: 614


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Implementing safety practices in healthcare saves lives and improves the quality of care: it is therefore vital to apply good clinical practices, such as the WHO surgical checklist, to adopt the most appropriate measures for the prevention of assistance-related risks, and to identify the potential ones using tools such as reporting & learning systems. The culture of safety in the care environment and of human factors influencing it should be developed from the beginning of medical studies and in the first years of professional practice, in order to have the maximum impact on clinicians' and nurses' behavior. Medical errors tend to vary with the level of proficiency and experience, and this must be taken into account in adverse events prevention. Human factors assume a decisive importance in resilient organizations, and an understanding of risk control and containment is fundamental for all medical and surgical specialties. This open access book offers recommendations and examples of how to improve patient safety by changing practices, introducing organizational and technological innovations, and creating effective, patient-centered, timely, efficient, and equitable care systems, in order to spread the quality and patient safety culture among the new generation of healthcare professionals, and is intended for residents and young professionals in different clinical specialties.
Bioethics is the application of ethics to the broad field of medicine, including the ethics of patient care, research, and public health. In this book, prominent authors from around the globe discuss the complexities of bioethics as they apply to our current world. Topics range from the philosophical bioethics of the evolution of thinking about marriage from a religious standpoint to the bioethics of radiation protection to value-based medicine and cancer screening for breast cancer. Bioethics in Medicine and Society is wide-ranging, with additional chapters on the ethics of geoengineering, complementary and alternative medicine, and end-of-life ethical dilemmas. Readers with find that the field of bioethics has broad implications throughout society from our most intimate interpersonal relationships to policies being implemented on a global scale.
A complete guide to understanding and applying clinical research results Ideal for both researchers and healthcare providers Understanding Clinical Research addresses both the operational challenges of clinical trials and the needs of clinicians to comprehend the nuances of research methods to accurately analyze study results. This timely resource covers all aspects of clinical trials--from study design and statistics to regulatory oversight--and it delivers a detailed yet streamlined overview of must-know research topics. The text features an accessible three-part organization that traces the evolution of clinical research and explains the bedrock principles and unique challenges of clinical experimentation and observational research. Reinforcing this content are real-life case examples--drawn from the authors' broad experience--that put chapter concepts into action and contribute to a working knowledge of integral research techniques. FEATURES: The most definitive guide to promoting excellence in clinical research, designed to empower healthcare providers to assess a study's strengths and weaknesses with confidence and apply this knowledge to optimize patient outcomes In-depth coverage of fundamental research methods and protocols from preeminent authorities provides readers with an instructive primer and a springboard for ongoing clinical research education Clear, comprehensive three-part organization: Section One: Evolution of Clinical Research offers a succinct history of clinical trials, drug regulations, and the role of the FDA while covering the impact of information technology and academic research organizations Section Two: Principles of Clinical Experimentation takes you through the typical phases of clinical trials in the development of medical products, from initial human subject research to postapproval surveillance studies Section Three: Observational Research highlights the underlying principles, pitfalls, and methods for case-control studies, cohort studies, registries, and subgroup analyses within randomized trials
The Oxford Textbook of Clinical Research Ethics is the first comprehensive and systematic reference on clinical research ethics. Under the editorship of experts from the U.S. National Institutes of Health of the United States, the book's 73 chapters offer a wide-ranging and systematic examination of all aspects of research with human beings. Considering the historical triumphs of research as well as its tragedies, the textbook provides a framework for analyzing the ethical aspects of research studies with human beings. Through both conceptual analysis and systematic reviews of empirical data, the contributors examine issues ranging from scientific validity, fair subject selection, risk benefit ratio, independent review, and informed consent to focused consideration of international research ethics, conflicts of interests, and other aspects of responsible conduct of research. The editors of The Oxford Textbook of Clinical Research Ethics offer a work that critically assesses and advances scholarship in the field of human subjects research. Comprehensive in scope and depth, this book will be a crucial resource for researchers in the medical sciences, as well as teachers and students.
Clinical Ethics introduces the four-topics method of approaching ethical problems (i.e., medical indications, patient preferences, quality of life, and contextual features). Each of the four chapters represents one of the topics. In each chapter, the authors discuss cases and provide comments and recommendations. The four-topics method is an organizational process by which clinicians can begin to understand the complexities involved in ethical cases and can proceed to find a solution for each case.
A groundbreaking text on how to deliver the highest quality patient care through professionalism in daily medical practice Five Star Doody’s Review: “This is an outstanding book for all clinicians and professors, indeed for everyone in medicine to help mentor and self-police the medical profession.” "Understanding Medical Professionalism is a 'must-have' for all involved in the healing arts. The book demystifies professionalism, bringing it from a philosophical, mystical concept to a practical everyday set of behaviors. The twelve chapters, in a uniform way, provide wonderful, real-life stories that illustrate the challenges faced by practitioners, describe ways to deal with those challenges, and help develop the personal and institutional skills necessary to provide excellent and compassionate care." -- Carlos A. Pellegrini, MD, FACS, FRCSI (Hon.), The Henry N. Harkins Professor and Chair, Department of Surgery, University of Washington "Insightful, practical, and authoritative. Building on their own research and that of others, Levinson et al. offer a comprehensive discussion of medical professionalism from the refreshing perspective of behavioral skills and an enabling healthcare system. Understanding Medical Professionalism has fundamentally reframed the professionalism debate and will likely remain the definitive work in this field for quite some time." -- David G. Nichols, MD, President and CEO, The American Board of Pediatrics "The authors' ambitious goal of providing a framework for the continuum of physician development of professional behaviors, from student through expert senior clinician, has been met. Students will find the text modular and instructive; residents will benefit from the reinforcement of positive professional behaviors and explication of strategies to excel in this competency; educational program directors will find the framework and tools for assessment and strategies for remediation enriching; and the expert professional will find subtle opportunities to grow to mastership of this most important physician competency." -- Thomas J. Nasca, MD, MACP, Chief Executive Officer, Accreditation Council for Graduate Medical Education, Professor of Medicine, Jefferson Medical College "The authors offer a framework and an approach to medical professionalism that enable us to understand it, teach it, and incorporate it into our day-to-day lives as health professionals. It is a much needed addition to our armamentarium as we work to align the education of health professionals with the needs and expectations of the society we serve." -- George E. Thibault, MD, President, Josiah Macy Jr. Foundation