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Esophageal cancer is a highly aggressive disease with a rising incidence, especially in the Western World. Almost half of the patients who present with esophageal cancer are beyond curative therapy, and for patients with potentially curable disease, 5-year survival rates rarely exceed 30%. Although surgical resection is the most important part of the treatment, evidence in favor of neoadjuvant treatment (i.e. chemo(radio)therapy prior to surgery) is accumulating. These multimodality treatment regimens can induce shrinkage of the tumor and thereby facilitate a microscopically radical resection, which is an important prognostic factor for survival. However, this potential benefit should outweigh the toxicity that neoadjuvant treatment adds to the already high morbidity and mortality that are associated with the curative resection of esophageal cancer. This thesis consists of two parts. In part one: "Preoperative analysis and treatment" the benefits of neoadjuvant chemoradiotherapy (nCRT) are described and the impact of several (pre-)clinical delays in the treatment are evaluated. Part two: "Postoperative outcome and prognostication" focusses on (disease-free) survival and prognostication after potentially curative treatment.
This issue of Surgical Clinics focuses on Esophageal Surgery and is edited by Drs. Thomas Fabian and John A. Federico. Articles will include: Epidemiology of premalignant and malignant tumors of the esophagus; Medical and endoluminal treatments of pre-malignant lesions and their outcomes; Staging of esophageal malignancies; Surveillance for, and management of, recurrent esophageal malignancy after endoscopic treatment; Surgical treatment for early cancers as style modality; Chemoradiation therapy as definitive treatment for esophageal cancer; Tri-modality approach for esophageal malignancies; Salvage esophagectomy; Consolidation therapy and adjuvant therapy after surgical resection: Immunotherapy or Targeted Therapy?; Palliation of esophageal cancer; Surveillance following treatment of esophageal cancer; Esophageal anastomotic techniques; Management of postoperative complications after esophageal resection; The biologic characteristics and clinical presentation of esophageal cancer; and more!
This Atlas presents a state-of-the-art review of VATS and robotic approaches to managing lung and esophageal cancers. It discusses cancer staging, physiological evaluation of patients, and patient selection for minimally invasive surgery. The atlas offers detailed descriptions of individual operations accompanied by anatomic drawings, intraoperative images, and 3-dimensional anatomic reconstructions. Written by recognized experts in the field, it provides readers with an unparalleled resource for advancing their skills in managing these cancers. It is a valuable reference work for thoracic surgeons in training as well as in practice who want to pursue minimally invasive surgery. It is unique in offering fully illustrated, step-by-step descriptions of the operative procedures.
This issue of Thoracic Surgery Clinics devoted to Therapy for Esophageal Cancer will be Guest Edited by Dr. Wayne Hofstetter. Articles in this issue include: Radiographic and Endoscopic staging of esophageal cancer; Endoscopic management of HGD/Early stage esophageal cancer; Induction chemotherapy for esophageal cancer; Personalizing therapy for esophageal cancer patients; Surgery for esophageal cancer: Goals of resection and optimizing outcomes (Lymph node dissection in esophageal cancer/R0 Resection); Standardizing Esophagectomy Complications; Adjuvant therapy (post-op) for esophageal cancer; Definitive CXRT for esophageal cancer; Salvage Esophagectomy in the management of recurrent or persistent esophageal cancer; and Quality of life after curative resection for esophageal cancer.
Squamous cell carcinoma of the esophagus has a lower incidence than other gastrointestinal tract cancer; however, there are many difficult issued related to the choice of appropriate therapy for these patients. In recent years, the use of multimodal treatment has greatly improved the prognosis of patients affected by this disease but several aspects of the oncological and surgical management are still controversial. This book aims to give a homogeneous approach to esophageal cancer treatment, based on the author’s lifetime experience in conjunction with exhaustive review of recent literature. In each chapter surgeons and oncologists will find appropriate tools for correct management of the diagnosis and therapy of this difficult disease. The book analyzes all the aspects of staging and treatment, such as modern diagnostic and staging techniques (MRI or PET-CT), endoscopic treatment of early cancer, new minimally invasive and open surgical techniques, and combined treatment. In addition, there are chapters dedicated to the postoperative course of these patients, as well as their quality of life, with indications for the correct follow-up and treatment of relapses.
The Handbook of Perioperative Pain Management is an up-to-date evidence-based guide to the effective management of perioperative pain even in the most challenging situations. It provides readers with an understanding of the physiology, pharmacology and psychology of acute pain together with guidelines for best practice. Examples of assessment documentation and guidelines for specific patient sub-groups are reproduced throughout the text.
THE ESOPHAGUS The Esophagus investigates the anatomy, physiology, and pathology of the esophagus. This sixth edition, revised and updated throughout, also explores the diagnosis and treatment of various esophageal conditions. It includes treatment guidelines approved by the two largest gastroenterology societies, the ACG and AGA, as befits a work co-edited by two former presidents of those organizations. Advancements in diagnostics are presented, as are developments in the surgical and drug therapies. Presented in full colour, and boasting an unrivalled team of editors and contributing authors, The Esophagus Sixth Edition will find a home wherever the anatomy, physiology, and pathology of the esophagus are studied and taught. This book is accompanied by a website containing all the figures from the book in PowerPoint format. www.wiley.com/go/richter/esophagus6e Praise for the Fifth Edition: “There is absolutely no doubt that this edition of the textbook will maintain its status as the go-to reference for esophageal conditions, and will remain a highly utilized and clinically useful resource for novice and experienced physicians and surgeons alike.” (Gastroenterology, 1 July 2013)
The comparison of established methods in surgery is necessary in order to evaluate the advantages or disadvantages of each. We have therefore tried to include discussions of all the problems which arise in the treat ment of long-gap esophageal atresia. The long-term results of different types of colonic interposition, of different "stretching" procedures, and of simple staged surgery seemed especially worthy of discussion. It was also important to describe the role of complications caused by special pathology of the trachea in esophageal atresia and their management. Second, new problems continue to arise with regard to the prenatal diagnosis of malformations. These new aspects will continue to exert an influence on our surgical field. Malformations pose severe problems for parents, the growing fetus, and the doctors and are lasting burdens on our task. PETER WURNIG, Vienna Contents I. Long-gap Esophageal Atresia Current Surgical Strategies in Long-gap Esophageal Atresia with Regard to Endoscopy Anastomosis. D. BooB and J. Kotlarski. With 7 Figures ... 1 Long-gap Esophageal Atresia: Experience with Kato's Instru mental Anastomosis, with Cervicothoracic Procedure and P- mary Anastomosis, and with Retrosternal Colonic Interposition. W. Ch. Hecker. With 6 Figures ... 9 Esophagus Replacement by Free, Autologous Jejunal Mucosa Transplantation in Long-gap Esophageal Atresia. H. Halsband. With 10 Figures ... 22 The Outcome of Colonic Replacement of the Esophagus in Ch- dren. A. Ahmed and L. Spitz. With 3 Figures ... 37 Gastric Tube Esophagoplasty. K.D. Anderson. With 1 Figure 55 The Significance of Tracheal Stenosis in Esophageal Atresia.