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Human life relies on two basic supplies from nature: oxygen and food. Oxygen can be utilized directly, but food has to go through a process of digestion to become usable nutrients. The esophagus represents the beginning of this long journey. Because of its critical location, esophageal cancer is one of the deadliest malignancies in the world, and furthermore its incidence has been rising steadily year after year while other cancers are declining. It is predicted that by the year 2035 the esophageal cancer population will increase by 77.4% and become one of top global concerns. This book covers many aspects of esophageal cancer, through which we hope to raise the awareness of professionals as well as non-professionals about this disease.
Human life relies on two basic supplies from nature: oxygen and food. Oxygen can be utilized directly, but food has to go through a process of digestion to become usable nutrients. The esophagus represents the beginning of this long journey. Because of its critical location, esophageal cancer is one of the deadliest malignancies in the world, and furthermore its incidence has been rising steadily year after year while other cancers are declining. It is predicted that by the year 2035 the esophageal cancer population will increase by 77.4% and become one of top global concerns. This book covers many aspects of esophageal cancer, through which we hope to raise the awareness of professionals as well as non-professionals about this disease.
Despite progress, esophageal cancer survival rates vary significantly. Early detection plays a crucial role. Unfortunately, symptoms like heartburn can be mistaken for less serious issues, leading to later diagnosis when the cancer is more aggressive. Additionally, socioeconomic factors can impact access to quality healthcare and optimal treatment options. Research also suggests disparities in screening and awareness between different demographics. Closing this survival gap requires a multi-pronged approach. Public awareness campaigns can educate people about early warning signs. Improved access to healthcare, particularly in underserved communities, is vital. Additionally, ongoing research into early detection methods and personalized treatment plans holds promise for narrowing the gap and offering a more hopeful future for all esophageal cancer patients.
​This book reviews the recent progress made in the prevention, diagnosis, and treatment of esophageal cancer. Epidemiology, molecular biology, pathology, staging, and prognosis are first discussed. The radiologic assessment of esophageal cancer and the role of endoscopy in diagnosis, staging, and management are then described. The principles of surgical resection, radiation therapy, and systemic chemotherapy for esophageal cancer are explained, and particular attention is paid to the multidisciplinary management of early-stage cervical, thoracic, distal, and junctional tumors. Up-to-date information is also provided on the treatment of metastatic and recurrent disease and on approaches that may affect future care, such as chemoprevention. Esophageal cancer remains one of the least studied cancers although it accounts for more than 400,000 deaths across the globe each year. The majority of esophageal cancers worldwide are squamous cell carcinomas, yet in the past few decades major epidemiologic changes have occurred affecting the incidence of adenocarcinomas in Western countries. Despite the advances in surgical and non-surgical therapies, overall survival has not changed significantly. It is hoped that Esophageal Cancer: Prevention, Diagnosis and Therapy will assist specialists from a variety of disciplines, including surgery, radiation therapy, gastroenterology, and medical oncology, in delivering optimal, up-to-date care to the benefit of patients.
"The Esophageal Cancer Mastery Bible: Your Blueprint for Complete Esophageal Cancer Management" is a comprehensive and compassionate guide that equips individuals and their loved ones with the knowledge and strategies needed to navigate the complexities of esophageal cancer. Beginning with an in-depth exploration of what esophageal cancer is and its various classifications, the book sheds light on the anatomy of the esophagus, the biological mechanisms behind cancer development, and crucial statistics that provide context. From risk factors to early signs and symptoms, the book offers a thorough understanding of the disease. The diagnostic journey is demystified, covering advanced techniques, biopsies, the TNM staging system, and prognosis based on stages. A dedicated section on the role of imaging prepares readers for crucial discussions about their diagnosis. Medical treatments are explored in detail, including surgery types, radiation therapy, chemotherapy regimens, targeted therapy, and the cutting-edge field of immunotherapy. Practical insights into managing treatment side effects and the potential of clinical trials are provided, offering hope and empowerment. This guide goes beyond medical treatments, addressing the emotional and practical aspects of living with esophageal cancer. From the psychological impact of the diagnosis to strategies for maintaining quality of life during treatment, the book is a holistic resource. Whether you're a patient, caregiver, or healthcare professional, "The Esophageal Cancer Mastery Bible" is a comprehensive roadmap for understanding, managing, and navigating the journey through esophageal cancer.
Gastrointestinal endoscopy is the principal tool for the investigation and treatment of most diseases of the gastrointestinal tract. The Atlas of Clinical Gastrointestinal Endoscopy offers a comprehensive overview of the role of gastrointestinal endoscopy in diagnosis. The atlas contains an abundance of high-quality images of a wide range of diseases of the upper and lower gastrointestinal tract, accompanied by precise clinical descriptions. Normal findings and variants are also documented. Furthermore, many images obtained by means of advanced image-enhanced endoscopy, capsule endoscopy, device-assisted enteroscopy, and endoscopic ultrasound are included. This book will be an ideal reference for both specialists and trainees in gastroenterology. It will provide the reader with an invaluable store of knowledge and with the clear guidance required in order to perform gastrointestinal endoscopy to best effect.
This Atlas presents a state-of-the-art review of VATS and robotic approaches to managing lung and esophageal cancers. It discusses cancer staging, physiological evaluation of patients, and patient selection for minimally invasive surgery. The atlas offers detailed descriptions of individual operations accompanied by anatomic drawings, intraoperative images, and 3-dimensional anatomic reconstructions. Written by recognized experts in the field, it provides readers with an unparalleled resource for advancing their skills in managing these cancers. It is a valuable reference work for thoracic surgeons in training as well as in practice who want to pursue minimally invasive surgery. It is unique in offering fully illustrated, step-by-step descriptions of the operative procedures.
Esophageal cancer is a highly aggressive disease with a rising incidence, especially in the Western World. Almost half of the patients who present with esophageal cancer are beyond curative therapy, and for patients with potentially curable disease, 5-year survival rates rarely exceed 30%. Although surgical resection is the most important part of the treatment, evidence in favor of neoadjuvant treatment (i.e. chemo(radio)therapy prior to surgery) is accumulating. These multimodality treatment regimens can induce shrinkage of the tumor and thereby facilitate a microscopically radical resection, which is an important prognostic factor for survival. However, this potential benefit should outweigh the toxicity that neoadjuvant treatment adds to the already high morbidity and mortality that are associated with the curative resection of esophageal cancer. This thesis consists of two parts. In part one: "Preoperative analysis and treatment" the benefits of neoadjuvant chemoradiotherapy (nCRT) are described and the impact of several (pre-)clinical delays in the treatment are evaluated. Part two: "Postoperative outcome and prognostication" focusses on (disease-free) survival and prognostication after potentially curative treatment.
The Esophageal Cancer Education Foundation (ECEF) www.fightec.org was formed in 2003 by Bart and Virginia Frazzitta. The initial purpose in establishing this 501 C 3 non-profit Organization was to help solicit funds for a CD ROM Project they had committed to fund for Memorial Sloan-Kettering Cancer Center. The project had a cost of $75,000. This was achieved and it served as the beginning of this Foundation geared to focus on a mission statement that covered three goals, namely: -To bring awareness and educate the public and medical community about this disease -To walk the journey with caregivers and with patients who have this disease -To support research projects that will lead to a test for early detection of this disease and also to hopefully cure this disease. ECEF has always kept its focus of not having a major expense factor and as such it does not now have any employees and its only major expense has been its web site development and CPA costs to certify our Financial Statements. We needed to do this to handle the members and patients who have joined ECEF and have availed themselves of the services we provide. We will continue this approach as long as we have the volunteers needed to run an effective and efficient operation. Should this change our goal will be to keep all administrative expenses to no more than 20% of the revenue we have generated. Bart Frazzitta a co-founder and a stage III adenocarcinoma esophageal cancer survivor has been the driving force behind ECEF. He was diagnosed in 1999 and went through chemotherapy, radiation therapy and ultimately Ivor Lewis surgery. He has co-authored a book called 100 Questions & Answers About Esophageal Cancer which provides patients and caregivers with not only the medical response to these selected 100 questions but also a response, from a patients perspective, which has proven helpful to the people who have read the book. Since this book is, in part, an introduction to this disease, he felt it necessary to produce this guide so that patients who have gone through this surgery can have a reference guide to help them navigate the issues they may face as they journey beyond this disease. It is intended to help with quality of life issues and should be looked at, with all the suggestions presented, as a guide to talk to the patient's physician. Please visit our web site www.fightec.org and see the services and information we provide to patients and caregivers and join us as we journey through this disease.