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One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas tases from it might be enhanced by suppression of immune and reticu loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.
In this issue of Thoracic Surgery Clinics, guest editors Drs. Jonathan Yeung and Elena Elimova bring their considerable expertise to the topic of Esophageal Cancer. Nearly 20,000 new cases of esophageal cancer are diagnosed each year in the U.S. alone. In this issue, top experts provide a timely update of this perennially important topic with coverage of pathology, genetics, staging, adjuvant therapies, and surgical management, as well as two special articles on controversies in esophageal cancer. - Contains 12 practice-oriented topics, including staging of esophageal cancer; endoscopic treatment of esophageal cancer; immunotherapy and targeted therapy for esophageal cancer; Ongoing Controversies in Esophageal Cancer I: feeding tubes, pyloroplasty, thoracic duct clipping; Ongoing Controversies in Esophageal Cancer II: gastrectomy vs esophagectomy for Siewert 2 esophageal cancer; and more. - Provides in-depth clinical reviews on esophageal cancer, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Recent randomized controlled trials comparing neoadjuvant chemoradiation plus surgery or perioperative chemotherapy plus surgery with surgery alone showed significant survival benefits for combined modality treatment of patients with localized esophageal adenocarcinoma. However, head-to-head comparisons of neoadjuvant chemoradiation and perioperative chemotherapy applying contemporary treatment protocols are lacking. The present trial was initiated to obtain valid information whether neoadjuvant chemoradiation or perioperative chemotherapy yields better survival in the treatment of localized esophageal adenocarcinoma. Proceeds from the sale of this book go to support an elderly disabled person.
Newly streamlined and focused on quick-access, easy-to-digest content, Mulholland and Greenfield’s Surgery: Scientific Principles & Practice, 7th Edition, remains an invaluable resource for today’s residents and practicing surgeons. This gold standard text balances scientific advances with clinical practice, reflecting rapid changes, new technologies, and innovative techniques in today’s surgical care. New lead editor Dr. Justin Dimick and a team of expert editors and contributing authors bring a fresh perspective and vision to this classic reference.
A surprisingly open memoir co-authored by the married duo of a world class oncologist and a cancer survivor about love, pain, hope, strength and resilience while navigating the overwhelming breast cancer advocacy movement. Off Our Chests recounts the story of Liza and John's experience with her diagnosis and treatment. Written in alternating voices, Liza details her treatment, the complex decisions she had to make throughout her course of chemotherapy and radiation, including clinical trial participation and an elective double mastectomy, the added complexity of being treated at the cancer center of which John was the chief of hematology and oncology, and the emotional impact of knowing she may die as a young woman with young children. John, who lost his own mother to cancer at the age of 13, provides an inside look into the world of cancer care and research, but also the perspective of someone who understands the medicine but who was unprepared for assuming the role of caregiver and worried husband. John adds insights into his world of running the clinical operations of the cancer center where Liza would receive her care, commentary on the breast cancer machine, the need for clinical research, the high cost of cancer care, and an easy to understand explanation of the clinical and scientific background of oncology. While they both felt that they were already expert commentators on their own "Cancer Channel" during the course of Liza's illness, they both came to realize how little understanding they truly had of what a cancer diagnosis does to the patient, caregivers, children, family members, and friends. Liza and John share their most intimate thoughts, including many that were previously unsaid--even between the two of them. Both gain an understanding of the other's life, a deeper appreciation of what it means to be a cancer patient, and of the emotional strains of being an oncologist where so many of the patients die on their watch.
In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize
This issue of Surgical Oncology Clinics of North America, guest edited by Drs. Usman Ahmad and Sudish Murthy, is devoted to Emerging Therapies in Thoracic Malignancies. Drs. Ahmad and Murthy has assembled expert authors to review the following topics: Mediastinal Germ Cell Tumors: Updates in Diagnosis and Management; Multidisciplinary Evaluation and Management of Early Stage Esophageal Cancer; Evaluation of Risk for Thoracic Surgery; Mesothelioma: Updates in Staging and Management; Chest Wall Sarcoma: When and Who to Resect and How to Reconstruct; Management of Locally Advanced Esophageal Cancer; Locally Advanced Lung Cancer and Salvage Resections; Siewert III Adenocarcinoma: Still Searching for the Right Treatment Combination; Current Indications for Pulmonary Metastasectomy; Lung Cancer Screening; Thymic Malignancies: Updates in Treatment and Staging; Intra-operative Detection and Assessment of Lung Nodules; Targeted Therapies, Immunotherapy and T-Cell Therapy in Lung Cancer; and more!
Treatment of Cancer is a multi-author work and comprehensive guide on modern cancer treatment that aims to give clinician and student alike the framework for an integrated approach to patient care, including radiotherapy, chemotherapy, and surgery. Much information is presented in tables and charts for easy assimilation, and clear algorithms for patient pathways are included to make decisions straightforward while allowing for sound clinical judgement.
In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.