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Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
This book focuses on practical applications for using adult and embryonic stem cells in the pharmaceutical development process. It emphasizes new technologies to help overcome the bottlenecks in developing stem cells as therapeutic agents. A key reference for professionals working in stem cell science, it presents the general principles and methodologies in stem cell research and covers topics such as derivitization and characterization of stem cells, stem cell culture and maintenance, stem cell engineering, applications of high-throughput screening, and stem cell genetic modification with their use for drug delivery.
This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.
In the United States… Mariana Mitogo is struggling to make ends meet. Then, out of the blue, she learns she’s to receive a huge inheritance that would erase all her debt. The problem: she has to be married for six months to receive it, and her dating life is nonexistent. In Spain… Santiago de los Reyes, Mariana’s Internet friend, has drained his bank account to support his family. Desperate to get his mom the heart surgery she needs, he interviews for a better-paying job that would take him from Madrid to Virginia. When he’s offered the position but can’t get a work visa, Mariana offers a solution that benefits both of them—a fiancé visa and a quick wedding. If anyone finds out it’s a green-card marriage, Santiago will be deported. Mariana would face a colossal fine and jail time. Good thing they’re committed actors. But as Santiago and Mariana pretend to build a life together, the lines blur between charade and reality. Will they dare to choose the love that feels more honest every day? Border Ctrl+Esc is a lighthearted friends-to-lovers marriage of convenience between LGBTQ+ Internet friends (a demisexual woman and a bisexual man).
Contains the reports of city officials for the preceding year.
A definitive resource, The ESC Textbook of Cardiovascular Imaging, second edition provides extensive coverage of all cardiovascular imaging modalities. Produced in collaboration with the European Association of Cardiovascular Imaging with contributions from specialists across the globe and edited by a distinguished team of experts, it is a 'state of the art' clinically-orientated imaging reference. Now fully revised and updated with the latest imaging techniques and technology and covering even more conditions than before, it not only discusses the principles of individual modalities but also clearly demonstrates the added value each technique can bring to the treatment of all cardiac diseases. Richly illustrated with colour figures, images, and tables and using a wealth of newly available evidence to link theory to practice, it demonstrates how these techniques can be used in the diagnosis of a range of cardiovascular diseases. Learning how to apply them in practice is made easy with free access to videos and imaging loops online along with the full text so that it is always available, even when on the move. Impressive in scope, The ESC Textbook of Cardiovascular Imaging contains information on cutting-edge technical developments in echocardiography, CT, CMR and hybrid imaging and well imaging's current role in cardiac interventions, such as identifying cardiac structures, helping to guide procedures and exclude possible complications. The application of imaging modalities in conditions such as valvular and coronary heart disease, heart failure, cardiomyopathies, peri-myocardioal disease, adult congenital heart disease and aortic disease, is also extensively considered. From discussion on improved imaging techniques and advances in technology, to guidance and explanation of key practices and theories, this new edition of The ESC Textbook of Cardiovascular Imaging is the ideal reference guide for cardiologists and radiologists alike.
The ESC Textbook of Heart Failure is the latest addition to the European Society of Cardiology (ESC) publications portfolio and is fully supported by the European Heart Failure Association. The textbook brings together internationally renowned experts in the field of heart failure to present an up-to-date understanding of all aspects of this chronic condition that worsens with time. It is estimated that the worldwide population of patients suffering from heart failure is approximately 26 million. This clinically oriented work reflects contemporary European guidelines from the ESC and the European Heart Failure Association and summarizes the latest evidence from clinical trials. Made up of eighteen different sections the textbook covers the epidemiology, etiology, prevention, pathophysiology, and clinical phenotypes of heart failure. The assessment and management of chronic, acute, and advance heart failure are all discussed in detail. As well as chapters dedicated to self-care and patient education, the multidisciplinary approach to heart failure management, and clinical trial design and interpretation. The future direction of the field is discussed throughout with separate chapters on digital health, big data, and telemedicine/remote monitoring in heart failure also included. A must read for cardiovascular healthcare specialists in Europe and across the world it should also appeal to those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, and specialist nurses too.
Sports and exercise have been intensely advocated as protective lifestyle measures which prevent or reduce the risk of severe health issues, including cardiovascular disease. More extreme forms of sports (for instance at high altitudes) have been identified as an important way of promoting cardiovascular adaptation, but have also been associated with adverse effects and even major cardiovascular events in predisposed individuals. Participating in more commonplace sports and exercise, such as football, may also increase a person's risk of cardiac events. This publication is timely in the light of a burgeoning number of clinical papers in the field. The ESC Textbook of Sports Cardiology provides an overview of the detection and treatment of cardiovascular disease in elite athletes and young sports professionals in training, as well as prevention. It will be useful for clinical cardiologists, sports physicians, and general physicians alike. Split into 11 key areas in sports cardiology, ranging from sudden cardiac death in athletes to the most common cardiovascular abnormalities seen in athletes, and to the effects of substance abuse and doping, the text is an invaluable resource covering all aspects of sports cardiology. Access to the digital version of the textbook is included with purchase of the printed version. Highly illustrated with embedded multimedia features, together with cross-referenced links to related content and primary research data in major journals in the field, the digital version provides users with a dynamic and forward-thinking resource. The ESC Textbook of Sports Cardiology is the second textbook from the European Association of Preventive Cardiology (EAPC) and aligns with ESC clinical practice guidelines and EAPC recommendations and position papers.
The ESC Textbook of Thrombosis is the third iteration of Therapeutic Advances in Thrombosis. Now a new addition to the European Society of Cardiology (ESC) publications portfolio, it is informed by the work of the ESC's Working Group on Thrombosis. Written by internationally renowned experts in the field of thrombosis, the textbook presents an up-to-date and in-depth review of all aspects of thrombosis and antithrombotic therapies. Not only does it reflect contemporary European guidelines from the ESC but also it also summarizes the latest evidence from clinical trials. Covering the topic in great detail with thirty-one chapters, the textbook is split into four sections: Pathophysiology of thrombosis, Clinical pharmacology of antithrombotic drugs, Therapeutic strategies, and Special situations. Appealing to the large community of cardiovascular healthcare specialists in Europe and across the world, the textbook is a must read for cardiologists dealing with acute and chronic coronary syndromes, atrial fibrillation, artificial heart valves and pulmonary embolism. It will also appeal to cardiac surgeons, cardiovascular researchers, and general physicians alike.