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With contribution by numerous experts
This volume provides readers with biotechnological aspects of ergot alkaloid production and genetic and physiological data. Toxicology and environmental risks of ergot infection and contamination of food and forage are also detailed
Ergot alkaloids produced by fungi have a basic chemical structure but different chemical moieties at substituent sites result in various forms of alkaloids that are distinguishable from one another. Since the ergoline ring structure found in ergot alkaloids is similar to that of biogenic amines (neurotransmitters), a variety of physiological effects can result after ingestion. Research involving ergot alkaloids is an increasing important global issue as more governments pass laws that limit permissible levels of ergot alkaloids in both foodstuffs and feedstuffs. Regardless of whether these compounds are found directly in foodstuffs or in feed/plants given to forage animals (i.e., cattle, horses, sheep, and goats), introduction of these compounds can complicate the food supply. In addition, toxicosis resulting from alkaloids can be a costly hindrance, with mounting annual production losses associated with forage-animal production systems that impact other agricultural and food based industries. Recent advances for the analysis of these compounds in different matrices as well as the understanding the role these compounds play in distinct biological pathways have begun to help address the issue. This Research Topic “Recent Investigations of Ergot Alkaloids Incorporated into Plant and/or Animal Systems“ has developed a novel platform where different groups share recent data in their investigations with ergot alkaloids. The presented collection of articles emphasizes the complexity of this issue and the multiple approaches necessary to resolve the global ergot alkaloid challenges.
This monograph reflects the continued and growing interest in ergot alkaloids due to their fascinating chemistry, multiple biological actions, their importance as therapeutically useful agents and the innovation of alkaloid biotechnology. As well as giving a brief review of recent literature, the book also illustrates the present problems of ergot research with emphasis on areas where knowledge is lacking and where research should be pursued further. It is hoped that the book will also stimulate integration of the individual fields of ergot alkaloid research. Its usefulness is enhanced by the inclusion of many illustrations, graphs, tables and over 700 references. The book is intended for advanced undergraduates in biochemistry and molecular biology, for graduates embarking upon studies of excessive metabolites of microorganisms, for chemists seeking to find some understanding of the more biological aspects of the subject, for biologists who require some knowledge of the chemical and molecular aspects, and for practitioners in bioindustry. The book is also helpful as a bibliographic source.
"Alkaloids" is intended for by chemistry, biochemistry, pharmacy, and other medical students, biologists, chemists, biochemists, and other professionals involved in the field of alkaloids. All chapters in this book are written by professionals in the areas of alkaloid chemistry, biology, pharmacy, and other interesting applications. The chapters cover interesting and less obvious information about different groups of alkaloids.
This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.