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The phenomenon of magnetic resonance: theoretical considerations; Experimental considerations: instrumentation and methodology; Applications of EPR and advanced EPR techniques to the study of protein structure and interactions; The application of EPR spectroscopy to lipid membranes; The application of EPR techniques to the study of DNA.
This edition is the most updated since its inception, is the essential text for students and professionals working in and around epidemiology or using its methods. It covers subject areas - genetics, clinical epidemiology, public health practice/policy, preventive medicine, health promotion, social sciences and methods for clinical research.
The most comprehensive book ever written on leatherback sea turtles. Weighing as much as 2,000 pounds and reaching lengths of over seven feet, leatherback turtles are the world’s largest reptile. These unusual sea turtles have a thick, pliable shell that helps them to withstand great depths—they can swim more than one thousand meters below the surface in search of food. And what food source sustains these goliaths? Their diet consists almost exclusively of jellyfish, a meal they crisscross the oceans to find. Leatherbacks have been declining in recent decades, and some predict they will be gone by the end of this century. Why? Because of two primary factors: human redevelopment of nesting beaches and commercial fishing. There are only twenty-nine index beaches in the world where these turtles nest, and there is immense pressure to develop most of them into homes or resorts. At the same time, longline and gill net fisheries continue to overwhelm waters frequented by leatherbacks. In The Leatherback Turtle, James R. Spotila and Pilar Santidrián Tomillo bring together the world’s leading experts to produce a volume that reveals the biology of the leatherback while putting a spotlight on the conservation problems and solutions related to the species. The book leaves us with options: embark on the conservation strategy laid out within its pages and save one of nature’s most splendid creations, or watch yet another magnificent species disappear.
Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.
This textbook covers the material for an undergraduate linear algebra course: vectors, matrices, linear transformations, computational techniques, geometric constructions, and theoretical foundations. The explanations are given in an informal conversational tone. The book also contains 100+ problems and exercises with answers and solutions. A special feature of this textbook is the prerequisites chapter that covers topics from high school math, which are necessary for learning linear algebra. The presence of this chapter makes the book suitable for beginners and the general audience-readers need not be math experts to read this book. Another unique aspect of the book are the applications chapters (Ch 7, 8, and 9) that discuss applications of linear algebra to engineering, computer science, economics, chemistry, machine learning, and even quantum mechanics.
Biological Synthesis of Nanoparticles and Their Applications gives insight into the synthesis of nanoparticles utilizing the natural routes. It demonstrates various strategies for the synthesis of nanoparticles utilizing plants, microscopic organisms like bacteria, fungi, algae and so forth. It orchestrates interdisciplinary hypothesis, ideas, definitions, models and discoveries associated with complex cell of the prokaryotes and eukaryotes. Highlights: Discusses biological approach towards the nanoparticle synthesis Describes the role of nanotechnology in the field of medicine and its medical devices Covers application and usage of the chemicals at the molecular level to act as catalysts and binding products for both organic and inorganic Chemical Reactions Reviews application in physics such as solar cells, photovoltaics and other usage Microorganisms can aggregate and detoxify substantial metals because of different reductase enzymes, which can diminish metal salts to metal nanoparticles. The readers after going through this book will have detailed account of mechanism of bio-synthesis of nanoparticles.
The massive growth of the Internet has made an enormous amount of infor- tion available to us. However, it is becoming very difficult for users to acquire an - plicable one. Therefore, some techniques such as information filtering have been - troduced to address this issue. Recommender systems filter information that is useful to a user from a large amount of information. Many e-commerce sites use rec- mender systems to filter specific information that users want out of an overload of - formation [2]. For example, Amazon. com is a good example of the success of - commender systems [1]. Over the past several years, a considerable amount of research has been conducted on recommendation systems. In general, the usefulness of the recommendation is measured based on its accuracy [3]. Although a high - commendation accuracy can indicate a user's favorite items, there is a fault in that - ly similar items will be recommended. Several studies have reported that users might not be satisfied with a recommendation even though it exhibits high recommendation accuracy [4]. For this reason, we consider that a recommendation having only accuracy is - satisfactory. The serendipity of a recommendation is an important element when c- sidering a user's long-term profits. A recommendation that brings serendipity to users would solve the problem of “user weariness” and would lead to exploitation of users' tastes. The viewpoint of the diversity of the recommendation as well as its accuracy should be required for future recommender systems.
All life starts as stardust and all life requires packaging for molecules, proteins, DNA, and other crucial bits. Introducing astrobiology, this book presents a provocative hypothesis for the environmental conditions and raw materials needed for life to begin and evolve on earth.