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New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz
In 2020, areas of particular importance for technology trends will include biotechnology, nanotechnology, materials technology, and information technology. This report, the companion document to The Global Technology Revolution 2020, Executive Summary (Silberglitt et al., MG-475-NIC, 2006), assesses in detail a sample of 29 countries with respect to their ability to acquire and implement 16 key technology applications.
A moving story of a woman with early onset Alzheimer's disease, now a major Academy Award-winning film starring Julianne Moore and Kristen Stewart. Alice Howland is proud of the life she worked so hard to build. At fifty, she's a cognitive psychology professor at Harvard and a renowned expert in linguistics, with a successful husband and three grown children. When she begins to grow forgetful and disoriented, she dismisses it for as long as she can until a tragic diagnosis changes her life - and her relationship with her family and the world around her - for ever. Unable to care for herself, Alice struggles to find meaning and purpose as her concept of self gradually slips away. But Alice is a remarkable woman, and her family learn more about her and each other in their quest to hold on to the Alice they know. Her memory hanging by a frayed thread, she is living in the moment, living for each day. But she is still Alice. 'Remarkable … illuminating … highly relevant today' Daily Mail 'The most accurate account of what it feels like to be inside the mind of an Alzheimer's patient I've ever read. Beautifully written and very illuminating' Rosie Boycot 'Utterly brilliant' Chrissy Iley
"Science tends to generalize, and generaliza tions mean simplifications . . . . And generaliza tions are also more satisfying to the mind than details. Of course, details and generalizations must be in proper balance: Generalizations can be reached only from details, while it is the generalization which gives value and interest to the detail:' . . . (A. Szent-Gyorgy, Science 1964) The first edition of this book, published in German as Tabak abhiingigkeit in 2001, was prompted by the fact that no single volume was available in Germany or elsewhere summarising the adverse repercussions of cigarette smoking on human health. As far as my own research was able to ascertain, the last comprehensive work dealing with this subject was writ ten in Germany by the Dresden internist, F. Lickint, whose Tabak und Organismus was published in 1939 by the Hip pokrates-Verlag. All subsequent monographs in this field have tended to focus on detailed aspects, and there has been no shortage of publications on subjects such as how smokers can quit smoking, healthy eating for smokers etc. Friends and colleagues abroad have urged me to prepare an English language version of Tabakabhiingigkeit. In gladly complying with this suggestion, I have intentionally prepared an up dated and slightly enlarged new edition, taking account of the rapidly proliferating literature on the subject up to the start of 2002. The harmful sequelae of smoking are played down by politicians in many industrialised countries, including Ger many.
"Part of this book adapted from "Introduction aux nanosciences et aux nanotechnologies" published in France by Hermes Science/Lavoisier in 2006."
ECPA BESTSELLER • A compelling emotional and spiritual case against hurry and in favor of a slower, simpler way of life “As someone all too familiar with ‘hurry sickness,’ I desperately needed this book.”—Scott Harrison, New York Times best-selling author of Thirst “Who am I becoming?” That was the question nagging pastor and author John Mark Comer. Outwardly, he appeared successful. But inwardly, things weren’t pretty. So he turned to a trusted mentor for guidance and heard these words: “Ruthlessly eliminate hurry from your life. Hurry is the great enemy of the spiritual life.” It wasn’t the response he expected, but it was—and continues to be—the answer he needs. Too often we treat the symptoms of toxicity in our modern world instead of trying to pinpoint the cause. A growing number of voices are pointing at hurry, or busyness, as a root of much evil. Within the pages of this book, you’ll find a fascinating roadmap to staying emotionally healthy and spiritually alive in the chaos of the modern world.
#1 NEW YORK TIMES BESTSELLER • Discover Jane Fonda, in her own words—and now experience the story of her life in the HBO documentary Jane Fonda in Five Acts. “To hold this book in your hands is to be astonished by how much living can be packed into sixty-plus years.”—Los Angeles Times America knows Jane Fonda as actress and activist, feminist and wife, workout guru and role model. In this extraordinary memoir, Fonda shows that she is much more. From her youth among Hollywood’s elite to her film career and her activism today, Fonda reveals intimate details and personal truths she hopes “can provide a lens through which others can see their lives and how they can live them a little differently.” Surprising, candid, and wonderfully written, My Life So Far is filled with insights into the personal struggles of a woman living a remarkable life. “In the process of writing this book I discovered there were clear, broad, even universal themes that ran through my life, a coherent arc to my journey that, if I could be truthful in the telling, might provide a road map for other women as they face the challenges of relationships, self-image, and forgiveness. What I did not anticipate was how my journey would also resonate with men.”—From the Introduction This eBook includes the full text of the book plus the following additional content: • 50 new photos from Jane Fonda’s personal and family archives, many often never seen in public • A free chapter from Jane Fonda’s Prime Time Praise for My Life So Far “[A] sisterly, enveloping memoir . . . an intimate, haunting book that might as well be catnip from its ever controversial author.”—Janet Maslin, The New York Times “Terrific . . . rich . . . unexpectedly quite moving.”—San Francisco Chronicle “Fiercely intelligent, detailed, probing, rigorously revealing.”—O: The Oprah Magazine “Fonda possesses a raw and affecting candor. . . . Her honesty [is] a force.”—The Philadelphia Inquirer “A fearless book . . . fascinating.”—Chicago Sun-Times “Truly compelling.”—The Atlanta Journal-Constitution “Riveting.”—Seattle Post-Intelligencer
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.