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Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
A Practical Guide to Writing a Ruth L. Kirschstein NRSA Grant provides F-Series grant applicants and mentors with insider knowledge on the process by which these grants are reviewed, the biases that contribute to the reviews, the extent of information required in an NRSA training grant, a deeper understanding of the exact purpose of each section of the application, and key suggestions and recommendations on how to best construct each and every section of the application. A Practical Guide to Writing a Ruth L. Kirschstein NRSA Grant is a solid resource for trainees and their mentors to use as a guide when constructing F30, F31, and F32 grant applications. - Covers F30, F31, and F32 grant applications - Detailed overview of the review process - Key suggestions on how to best construct each section of the application - Includes a checklist of required items
This fully revised and corrected edition of the International Classification of Primary Care 2e (ICPC-2) is indispensable for anyone wishing to use the international classification system for classificaton of morbidity data in a primary care setting. The concept of ICPC-2 has not been changed but the main body of the actual classification (chapter 10) has been completely revised to reflect the adequate use for an individual patient record and for research purposes. This now brings the printed version of ICPC-2 completely in-line with the electronic version previously only available through the Oxford Website for the journal Family Practice. ICPC-2 is patient-oriented rather than disease or provider-oriented. It encompasses both the patient's reason for encounter and the patient's problem. ICPC-2 is extensively used internationally and includes a detailed conversion system for linking the ICPC and ICD-10 codes published by WHO, additional inclusion criteria, and cross-referencing rubrics. ICPC-2 It has been developed based on the recognition that building the appropriate primary care systems to allow the assessment and implementation of health care priorities is possible only if the right information is available to health care planners.
At a time when lesbian, gay, bisexual, and transgender individuals-often referred to under the umbrella acronym LGBT-are becoming more visible in society and more socially acknowledged, clinicians and researchers are faced with incomplete information about their health status. While LGBT populations often are combined as a single entity for research and advocacy purposes, each is a distinct population group with its own specific health needs. Furthermore, the experiences of LGBT individuals are not uniform and are shaped by factors of race, ethnicity, socioeconomic status, geographical location, and age, any of which can have an effect on health-related concerns and needs. The Health of Lesbian, Gay, Bisexual, and Transgender People assesses the state of science on the health status of LGBT populations, identifies research gaps and opportunities, and outlines a research agenda for the National Institute of Health. The report examines the health status of these populations in three life stages: childhood and adolescence, early/middle adulthood, and later adulthood. At each life stage, the committee studied mental health, physical health, risks and protective factors, health services, and contextual influences. To advance understanding of the health needs of all LGBT individuals, the report finds that researchers need more data about the demographics of these populations, improved methods for collecting and analyzing data, and an increased participation of sexual and gender minorities in research. The Health of Lesbian, Gay, Bisexual, and Transgender People is a valuable resource for policymakers, federal agencies including the National Institute of Health (NIH), LGBT advocacy groups, clinicians, and service providers.
Elephants are possibly the most well-known members of the animal kingdom. The enormous size, unusual anatomy, and longevity of elephants have fascinated humans for millenia. Biology, Medicine, and Surgery of Elephants serves as a comprehensive text on elephant medicine and surgery. Based on the expertise of 36 scientists and clinical veterinarians, this volume covers biology, husbandry, veterinary medicine and surgery of the elephant as known today. Written by the foremost experts in the field Comprehensively covers both Asian and African elephants Complete with taxonomy, behavioral, geographical and systemic information Well-illustrated and organized for easy reference
A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
This volume describes, illustrates, and analysis the finds from the excavations at Dra Abu el-Naga, an important necropolis on the east bank of the Nile in Luxor (Egypt), which was in use from Middle Kingdom times until the early Christian era. Excavations of the site have been conducted by the German Archaeological Institute (DAI). A wide variety of leather objects or objects with leather parts have been discovered, including footwear, musical objects, loincloths as well as parts of furniture. The dating of these objects, mirroring the variety, ranges from Pharaonic to Ottoman. The present work describes these finds in detail, accompanied by colour photographs and drawings. The analysis includes the discussion of the provenance of the finds, the interpretation of the objects from a technological as well as typological point of view and dating. Dr. André J. Veldmeijer, Visiting Research Scholar of the American University in Cairo, has worked as an archaeologist in Egypt since 1995, specialising in, among other things, leatherwork and footwear. He (co-)directs several projects, including the Ancient Egyptian Leatherwork Project, which encompasses the Egyptian Museum Chariot Project and the Tutankhamun's Sticks & Staves Project. He has published extensively, both for scientific and popular audiences.