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This book provides an overview of nanoparticle production methods, scale-up issues drawing attention to industrial applicability, and addresses their successful applications for commercial use. There is a need for a reference book which will address various aspects of recent progress in the methods of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization. There is no consolidated reference book that discusses the emerging technologies for nanoparticle manufacturing. This book focuses on the following major aspects of emerging technologies for nano particle manufacturing. I. Introduction and Biomedical Applications of Nanoparticles II. Polymeric Nanoparticles III. Lipid Nanoparticles IV. Metallic Nanoparticles V. Quality Control for Nanoparticles VI. Challenges in Scale-Up Production of Nanoparticles VII. Injectable Nanosystems VIII. Future Directions and Challenges Leading scientists are selected as chapter authors who have contributed significantly in this field and they focus more on emerging technologies for nanoparticle manufacturing, future directions, and challenges.
This unique volume describes advances in the field of mechanochemistry, in particular the scaling up of mechanochemical processes. Scalable techniques employed to carry out solvent-free synthesis are evaluated. Comparability to continuous flow chemistry, the current industrial benchmark for continuous efficient chemical synthesis, is presented.The book concludes that mechanochemical synthesis can be scaled up into a continuous, sustainable process. It demonstrates that large-scale mechanochemistry can meet industrial demands, especially in the pharmaceutical industry. Features Mechanochemistry is rapidly developing as a multidisciplinary science on the borderline between chemistry, materials science and environmental science This unique text focuses on mechanochemistry with the ability to scale up and illustrates how mechanochemical synthesis is no longer an obstacle This timely book highlights recent advancements describing what can be achieved in chemical synthesis Mechanochemistry enables the synthesis of multiple polymorphic crystalline forms in the production of drugs in the form of tablets or granules in capsules
Emerging Nanotechnologies in Immunology aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular, and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure.The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular, and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body.The contributors addresses a representative set of the broad spectrum of nanopharmaceuticals currently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use. - Provides the reader with a thorough knowledge of the safety aspects of nanopharmaceuticals which are currently under research - Focuses on the characterization and quantification of the nanopharmaceuticals - Allows readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects - Includes an overview of regulatory aspects related to the R&D of nanopharmaceuticals
This book highlights recent developments related to fabrication and utilization of nanoparticle-engineered metal matrices and their composites linked to the heavy industries, temperature fasteners, high-pressure vessels, and heavy turbines, etc. The mechanical properties of newly developed metallic composites are discussed in terms of tensile modulus, hardness, ductility, crack propagation, elongation, and chemical inertness. This book presents the design, development, and implementation of state-of-the-art methods linked to nanoparticle-reinforced metal nanocomposites for a wide variety of applications. Therefore, in a nutshell, this book provides a unique platform for researchers and professionals in the area of nanoparticle-reinforced metal nanocomposites.
Nanomaterials from Renewable Resources for Emerging Applications details developments in nanomaterials produced from renewable materials and their usage in food and packaging, energy conservation, and environmental applications. • Introduces fundamentals of nanomaterials from renewable resources, including processing and characterization. • Covers nanomaterials for applications in food and packaging, including nanocellulose, lignin- and chitosan-based nanomaterials, and nanostarch. • Discusses applications in energy conservation, such as supercapacitors, electrolyte membranes, energy storage devices, and insulation. • Describes environmental uses such as water remediation and purification and oil spill clean-ups. • Highlights advantages and challenges in commercialization of green nanoparticle-based materials. Equally beneficial to researchers and professionals, this book is aimed at readers across materials science and engineering, chemical engineering, chemistry, and related fields interested in sustainable engineering.
This book discusses the development, characterization, and applications of nanocomposites, which are advanced materials obtained through the combination of two or more constituents, with one being a continuous phase (matrix) and the other being a discontinuous or dispersed nanophase. Nanocomposites have gained significant attention due to their excellent properties and multiple applications, resulting from synergistic effects between the matrix and reinforced nanophase. Nanocomposites offer advantages over individual nanoparticles in tailoring properties, enhancing stability, and optimizing performance for specific applications. This book emphasizes the vast potential of nanocomposites in various areas, including water treatment, food packaging, automotive compounds, biomedical devices, coatings, sensors, pharmaceuticals, and fuel cells, among others. The properties of nanocomposites are highly dependent on their structure and dimensions, and further research is needed to better understand the structure-property relationship in these systems. The book includes sixteen chapters organized into four sections: “Carbon-Based Nanocomposites”, “Inorganic Nanoparticles-Based Nanocomposites”, “Nanocomposites for Environmental Applications”, and “Nanocomposites for Biomedical Applications”.
Artificial Intelligence for Drug Product Lifecycle Applications explains the use of artificial intelligence (AI) in drug discovery and development paths, including the clinical and postapproval phases. This book gives methods for each of the drug development steps, from the fundamentals to postapproval drug product. AI is a synergistic assembly of enhanced optimization strategies with particular applications in pharmaceutical development and advanced tools for promoting cost-effectiveness throughout the drug lifecycle. Specifically, AI brings together the potential to improve drug approval rates, reduce development costs, get medications to patients faster, and help patients comply with their treatments.Accelerated pharmaceutical development and drug product approval rates will enable larger profits from patent-protected market exclusivity. This book offers the tools and knowledge to create the right AI strategy to extend the landscape of AI applications across the drug lifecycle. It is especially useful for pharmaceutical scientists, health care professionals, and regulatory scientists, as well as advanced students and postgraduates actively involved in pharmaceutical product and process development involving the use of artificial intelligence in drug delivery applications. - Classifies AI methodologies and application examples into different categories representing the various steps of the drug development cycle - Combines timely literature review with clear artworks to improve understanding - Examines deep learning and machine learning in drug discovery
The use of nanomaterials for remediation efforts has been overlooked even though they present interesting characteristics as remediators. This new book provides a valuable overview of low-cost and eco-friendly green synthesized nanomaterials as advantageous technology that promotes efficient nanoremediation of environmental pollution for the restoration of polluted areas. It discusses the potential of nanomaterials, specifically green synthesized nanomaterials, as a practical and efficient solution toward sustainability. The book details the advantages of green nanomaterials when compared to conventional physicochemical methods, such as avoiding the use of harmful reagents and reducing toxic waste production. The book addresses themes such as contaminants associated with environmental pollution and the threats to humans; nanoremediation strategies that use microbes, plants, or amendments; and nanoparticles as tools for nanoremediation and their advantageous characteristics.
Making polymers into nanoparticles as an essential step in polymer solution processing is of key importance for many applications of polymers. This book seeks to uncover the basics and recent advances in polymer nanoparticles, including polymer synthesis, self-assembly, properties, and applications. It encompasses the various preparation methods of polymer nanoparticles, broadly ranged from single chain collapse to polymerization methods and solution self-assembly. It showcases a wide range of advanced applications of polymer nanoparticles in several fields that include pharmaceutics (drug and nucleotide delivery), biomedicals (bioimaging, diagnosis, and therapeutics), energy (batteries and solar cells) and environmental (catalysis and water purification).This book is enriched with a comprehensive range of content, incorporating synthesis, properties and applications in polymeric nanoparticles that will serve as a suitable beginner guide and survey book in polymer nanomaterials, as well as a useful tool for graduate students, scientists and practitioners in related fields or industries such as chemistry, materials science and engineering, nanomaterials, energy storage and conversion devices, and biomedicine.