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This extraordinary book covers the extremely broad subject of electropharmacology-defined here as the application of principles and methods of electrochemistry to biological topics associated with the action of drugs. It focuses on the physical principles of the movement of electrical charges across interfaces in pharmacological phenomena. It also covers drugs and the electrical procedures which modify a natural process having an electrochemical basis or component. This outstanding report studies the pharmacologically important properties and effects by electrochemical methods, the electrochemical alternatives or adjuncts to drug therapy, and the pharmacology involved. Easy to read and understand, this is an ideal reference for all researchers and practitioners of pharmacology and related fields.
Proceedings of a congress serve the purpose to provide the reader with the latest know ledge in the specific field. They present at least for a limited time period a reference book that allows rapid access to the latest information for the medical profession and for an ongoing of future research. This volume is addressed not only to the participants of the VIIth World Symposium on Cardiac Pacing but to everybody involved in diagnostic and therapeutic cardiac stimula tion. The experience has shown that proceedings of conferences of comparable size are usually published with a considerable time delay limiting its value as a source of prime informa tion. The editors of this volume decided therefore, that their most important task was to guarantee the actuality of the publication. Even if it seems desirable to include as many presentations of a conference as possible, the large number of excellent presentations at the VIIth World Symposium on Cardiac Pacing, 337 oral presentations and 236 posters, could not be published within an accepta ble time period. The experience from previous conferences has shown that a book which includes all the papers can only be edited with a large delay, which reduces the value and actuality of the information.
Focuses on the common clinical features, diagnosis, and management of the full range of rhythm disorders, highlighting basic science only where necessary. To-the-point and practical, this text discusses everything from cardiac rhythms and arrhythmias to disease states associated with cardiac arrhythmias to the latest pharmacologic and interventional therapies. It outlines the common clinical features of rhythm disorders and how to treat and manage them, and features a mini-textbook of mechanisms, identification, analysis, and prognosis for most common arrhythmia types in the section on rhythms and arrhythmias. Included are discussions on hot topics such as genetics and cardiac arrhythmias, Brugada syndrome, and devices for the management of atrial fibrillation.
In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. Unfortunately, it is increasingly recognised that a number of drugs, both those associated with altering repolarisation, and others for non-cardiac conditions can increase the propensity for polymorphic ventricular tachycardia, syncope and even ventricular fibrillation and sudden death. In this volume, arrhythmia specialists from St. George’s Hospital Medical School, London discuss the mechanisms behind QT prolongation and torsades de pointes. They focus particularly on the risk of individual cardiac and non-cardiac drugs in provoking long QT syndrome, providing a comprehensive review which will be useful for all electrophysiologists treating polymorphic ventricular tachycardias, and will expose important regulatory issues for pharmaceutical authorities and for the wider medical community.
Comparative Diagnostic Pharmacology: Clinical and Research Applications in Living-System Models is the first evidence-based reference text devoted exclusively to the subject of applying pharmaceutical and biopharmaceutical agents as diagnostic probes in clinical medicine and investigative research.This unique and groundbreaking book is a versatile guide for clinicians and researchers interested in using pharmacologic agents to: Diagnose disease Assess physiological processes Identify the appropriateness of a therapeutic agent Determine appropriate dosing for therapeutic use. Extensively referenced and organized by major body systems, individual topics are listed in an evidence-based format according to specific disease processes or physiological processes of interest. Each entry also includes information on the mechanism of action, administration, and diagnostic interpretation. Descriptions have been provided for the application of diagnostic pharmaceuticals to assess a wide spectrum of diseases and physiological processes relevant to the fields of veterinary and human medicine. Comparative Diagnostic Pharmacology is useful not merely for pharmaceutical-oriented research investigations, but it will also prove invaluable for the monitoring and evaluation of physiological responses and disease processes in animal models.
A comprehensive coronary care textbook for medical, nursing and paramedic staff The Coronary Care Manual, 2nd Edition is a practical medical manual designed to assist with management of the acute coronary patient. This respected medical resource is written by a group of coronary experts, both Australian and international. Its aim is to strike a balance between a large and rapidly-changing evidence base and practical application in the Coronary Care Unit, Intensive Care Unit, Emergency Department and the ambulance. The second edition of this important health textbook covers an extensive range of coronary care medicine, providing a handy companion for a night 'on call'. Chapter topics in the Coronary Care Manual, 2nd Edition include pathophysiology, drug and non-drug therapies and postcoronary management, with chapters organised into subsections. Completely redesigned with fresh, new artwork, this new edition of the Coronary Care Manual is organised to suit academics and medical practitioners alike.
The thoroughly updated Second Edition of this highly acclaimed text provides a concise yet comprehensive reference on the clinical and scientific principles of cardiovascular and thoracic anesthesia. The foremost authorities in cardiac anesthesia cover topics particular to this specialized field, such as extracorporeal circulation, transesophageal echocardiography, the physiology and pharmacology of anticoagulation, cardiac catheterization, invasive cardiology, and congenital heart disease. Ideal for residents, fellows, and practicing anesthesiologists, this important text provides comprehensive, practical guidance for all aspects of cardiac anesthesia.