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DeFelice presents this intricate subject in an easy-to-follow, stepwise fashion: he reviews the fundamentals of electricity; transfers those principles to a biological context; and expands the discussion to encompass the subject's practical dimensions. Clear definitions and intuitive descriptions characterize the presentation, which is complemented by over 150 drawings and graphs. Mathematics is kept to the minimum necessary. The text covers both excitable and non-excitable membranes and includes the plasma membrane as well as intracellular membranes. A unique, `electronics-made-simple' appendix, designed specifically for biologists, treats the operational amplifiers used in patch clamp, and other appendices offer solutions to equations and examples that illustrate principles.
Cellular Physiology of Nerve and Muscle, Fourth Edition offers a state of the art introduction to the basic physical, electrical and chemical principles central to the function of nerve and muscle cells. The text begins with an overview of the origin of electrical membrane potential, then clearly illustrates the cellular physiology of nerve cells and muscle cells. Throughout, this new edition simplifies difficult concepts with accessible models and straightforward descriptions of experimental results. An all-new introduction to electrical signaling in the nervous system. Expanded coverage of synaptic transmission and synaptic plasticity. A quantitative overview of the electrical properties of cells. New detailed illustrations.
Cellular biophysics is the branch of biophysics that studies cells from the perspective of a physicist or physical chemist by applying physical methods to interrogate cell structure and function, and developing models of cells using physics and physical-chemical principles. The fundamental unit of all biological life is the cell, a mass of biomolecules in watery solution surrounded by a cell membrane. One of the characteristic features of a living cell is that it controls the exchange of electrically charged ions across the cell membrane and therefore the electrical potential of its interior relative to the exterior. The organization and activities of cells are major themes in cellular biophysics, and studies have focused on observing complex structures inside cells, detecting cellular activities, and extending methods developed to study purified biological molecules to microscope-based cellular measurements. Microscopy, which functions across multiple scales of time and spatial resolution, is at the center of these studies. Most cells and tissues have electrical properties relevant to their natural function. Most cells and tissues have rather complex structure, consisting of folding and invaginating membranes and specialized connections and organelles. The localization of electrical properties is particularly important, since each of the complex structures must be expected to have a specific role in the electrical function of the tissue. Cellular Biophysics, Electrical Properties fosters progress and innovations in comprehending the nature of the biophysical mechanisms underlying the control of cellular physiological homeostasis and the consequences of its perturbation. Electrical signals are fundamental to nervous system function. The electrical properties of cells are important in determining how electrical signals spread along plasma membrane. This Advanced Topic explores the electrical characteristics of cell membranes as electrical conductors and insulators. These passive electrical properties arise from the physical properties of the membrane material and from the ion channels in the membrane. This book will serve as valuable guide for advanced graduate students and researchers dealing with the bioengineering, biophysics, physiology, and neuroscience areas, and will serve as a valued tool for biophysicists as well.
An informal and highly accessible writing style, a simple treatment of mathematics, and clear guide to applications, have made this book a classic text in electrical and electronic engineering. Students will find it both readable and comprehensive. The fundamental ideas relevant to the understanding of the electrical properties of materials are emphasized; in addition, topics are selected in order to explain the operation of devices having applications (or possible future applications) in engineering. The mathematics, kept deliberately to a minimum, is well within the grasp of a second-year student. This is achieved by choosing the simplest model that can display the essential properties of a phenomenom, and then examining the difference between the ideal and the actual behaviour. The whole text is designed as an undergraduate course. However most individual sections are self contained and can be used as background reading in graduate courses, and for interested persons who want to explore advances in microelectronics, lasers, nanotechnology and several other topics that impinge on modern life.
This open access book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner. Describes construction and application of computational human models including anatomically detailed and subject specific models; Explains new practices in computational human modeling for neuroelectromagnetics, electromagnetic safety, and exposure evaluations; Includes a survey of modern applications for which computational human models are critical; Describes cellular-level interactions between the human body and electromagnetic fields.
Cellular Biophysics is a quantitatively oriented basic physiology text for senior undergraduate and graduate students in bioengineering, biophysics, physiology, and neuroscience programs. It will also serve as a major reference work for biophysicists. Developed from the author's notes for a course that he has taught at MIT for many years, these books provide a clear and logical explanation of the foundations of cell biophysics, teaching transport and the electrical properties of cells from a combined biological, physical, and engineering viewpoint. Each volume contains introductory chapters that motivate the material and present it in a broad historical context. Important experimental results and methods are described. Theories are derived almost always from first principles so that students develop an understanding of not only the predictions of the theory but also its limitations. Theoretical results are compared carefully with experimental findings and new results appear throughout. There are many time-tested exercises and problems as well as extensive lists of references. The volume on the electrical properties of cells covers both electrically inexcitable cells as well as electrically excitable cells such as neurons and muscle cells. Included are chapters on lumped-parameter and distributed-parameter models of cells, linear electric properties of cells, the Hodgkin-Huxley model of the giant axon of the squid, saltatory conduction in myelinated nerve fibers, and voltage-gated ion channels.
Learn to use computational modelling techniques to understand the nervous system at all levels, from ion channels to networks.
"A classic text in the field, providing a readable and accessible guide for students of electrical and electronic engineering. Ideal for undergraduates, the book is also an invaluable reference for graduate students and others wishing to explore this rapidly expanding field." -Cover.