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This volume explores the main applications of elastographic techniques in hepatological and gastroenterological diseases, and elaborates on the use of these diagnostic techniques in a broad range of clinical settings; in this regard, it provides a clear critical methodological approach to the correct indication, taking into account the existing diagnostic pathways, the actual diagnostic accuracy of elastographic techniques, and their impact on clinical practice in terms of correct positioning of the test in the diagnostic pathway and clinical outcomes improvement. In the first chapters, which focus on the correct methodology for Diagnostic Accuracy Assessment of non -invasive techniques, the architecture of diagnostic research is discussed. In turn, the following sections describe a broad range of clinical applications in hepatology and gastroenterology. The closing section presents a number of case studies on practical issues, together with a critical discussion on how to promote the appropriate use of these technologies. Given its scope, the book will be of interest to specialists, post-graduate medical students, and researchers in the fields of hepatology and gastroenterology.
This is the first comprehensive book on the new elastographic techniques discussing the early assessment of liver fibrosis. The book covers all aspects of measuring liver stiffness starting from the methodology, the molecular basis of liver stiffness elevation up to current clinical algorithms and interpretation. Future directions and novel implications that go beyond diagnosis but are relevant for understanding of liver cirrhosis per se are also discussed in detail. Liver Elastography, is an essential companion for hepatologists and gastroenterologists that provides an overview of its basic principles and gives a detailed account of how to use elastrography in clinical practice.
This volume explores the main applications of elastographic techniques in hepatological and gastroenterological diseases, and elaborates on the use of these diagnostic techniques in a broad range of clinical settings; in this regard, it provides a clear critical methodological approach to the correct indication, taking into account the existing diagnostic pathways, the actual diagnostic accuracy of elastographic techniques, and their impact on clinical practice in terms of correct positioning of the test in the diagnostic pathway and clinical outcomes improvement. In the first chapters, which focus on the correct methodology for Diagnostic Accuracy Assessment of non -invasive techniques, the architecture of diagnostic research is discussed. In turn, the following sections describe a broad range of clinical applications in hepatology and gastroenterology. The closing section presents a number of case studies on practical issues, together with a critical discussion on how to promote the appropriate use of these technologies. Given its scope, the book will be of interest to specialists, post-graduate medical students, and researchers in the fields of hepatology and gastroenterology. .
The first book to cover the groundbreaking development and clinical applications of Magnetic Resonance Elastography, this book is essential for all practitioners interested in this revolutionary diagnostic modality. The book is divided into three sections. The first covers the history of MRE. The second covers technique and clinical applications of MRE in the liver with respect to fibrosis, liver masses, and other diseases. Case descriptions are presented to give the reader a hands-on approach. The final section presents the techniques, sequence and preliminary results of applications in other areas of the body including muscle, brain, lung, heart, and breast.
Elastography, the science of creating noninvasive images of mechanical characteristics of tissues, has been rapidly evolving in recent years. The advantage of this technique resides in the ability to rapidly detect and quantify the changes in the stiffness of soft tissues resulting from specific pathological or physiological processes. Ultrasound elastography is nowadays applied especially on the liver and breast, but the technique has been increasingly used for other tissues including the thyroid, lymph nodes, spleen, pancreas, gastrointestinal tract, kidney, prostate, and the musculoskeletal and vascular systems. This book presents some of the applications of strain and shear-wave ultrasound elastography in hepatic, pancreatic, breast, and musculoskeletal conditions.
This unique book provides detailed insight into a wealth of expert experience in liver pathology, with an in-depth review of the expertÌs analysis and diagnostic process supported by high-quality color photomicrographs and discussion of the diagnostic principles involved in evaluating these lesions. The diagnostic problems and cases selected show the wide range of specimens seen in liver pathology and address the difficult issues in diagnosis encountered in these lesions. Chapters and cases are authored by many of the leading experts and educators in liver pathology today. Liver Pathology will be essential reading for every pathologist who evaluates liver pathology specimens. In addition it will be a valuable resource for pathology residents and fellows. All Consultant Pathology Titles Provide: Actual consultation cases and expert analysis Expert analysis provides a detailed discussion of the reasoning behind the diagnosis of each case Comprehensive coverage of challenging diagnoses The cases are richly illustrated with high-quality photomicrographs
Ultrasound-based elastography techniques have received considerable attention in the last years for the noninvasive assessment of tissue mechanical properties. These techniques have the advantage of detecting tissue elasticity changes occurring in various pathological conditions and are able to provide qualitative and quantitative information that serves diagnostic and prognostic purposes. For liver applications and especially for the noninvasive assessment of liver fibrosis, ultrasound-based elastography has shown promising results. Several ultrasound elastography techniques using different excitation methods have been developed. In general, these techniques are classified into strain elastography, which is a semi-quantitative method that uses internal or external compression for tissue stimulation, and shear wave elastography, which measures the ultrasound-generated shear wave speed at different locations in the tissue. All liver elastography techniques have a standardized examination technique, with the patient in a supine position, while the measurements are performed through the right liver lobe. There are also some confounding factors that need to be taken into account when performing liver elastography such as a higher level of aminotransferases, infiltrative liver disease, liver congestion, cholestasis. This chapter briefly introduces the basic principles of liver elastography and discusses some important clinical aspects of elastography, such as the examination technique and the limitations.
This book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation. The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation. This is an invaluable book for clinicians, practitioners including academics, scientists/researchers and postgraduates to provide the newest knowledge in the field of liver pathogenesis. It is written by a multidisciplinary team of experts in hepathology, gastroenterology, and surgery especially from liver transplantation.
Elastography is useful for diagnosing and grading hepatic fibrosis in patients with chronic liver diseases (CLD). In addition, it may be used as a noninvasive tool for surveillance and prognostication of patients with complications related to CLD. Elastography uses real-time ultrasound to assess for tissue elasticity and is a fast, simple, reproducible, and reliable method for noninvasive liver fibrosis evaluation. Management of chronic liver disease is dependent on the grade of liver fibrosis to ascertain the urgency and choice of treatment and advice on further screening for cirrhosis and hepatocellular carcinoma. This chapter will highlight the role of elastography in the evaluation of chronic liver disease including hepatitis B and C and HIV-related liver disease and nonalcoholic fatty liver disease (NAFLD).