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This atlas illustrates the latest available data on the cancer epidemic, showing causes, stages of development, and prevalence rates of different types of cancers by gender, income group, and region. It also examines the cost of the disease, both in terms of health care and commercial interests, and the steps being taken to curb the epidemic, from research and screening to cancer management programs and health education.
World Cancer Report 2014 provides a professional, multidisciplinary assessment of all aspects of the geographical distribution, biology, etiology, prevention, and control of cancer, predicated on research. World Cancer Report is designed to provide non-specialist health professionals and policy-makers with a balanced understanding of cancer control and to provide established cancer professionals with insights about recent developments.
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef
The WHO Classification of Head and Neck Tumours is the ninth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumors. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies evaluating response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. The book, prepared by 135 authors from 35 countries, contains more than 600 color images and tables, and more than 2700 references. This book is in the series commonly referred to as the "Blue Book" series.
Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
Comprender el cáncer NO es un libro de autoayuda, ni de curas milagrosas, ni de pseudociencia, ni un panfleto de una farmacéutica, sino un libro que resume lo que nos gustaría que nos explicasen los (buenos) médicos sobre el cáncer si tuviesen más tiempo para hablar con los pacientes. En él encontrarás información actualizada y rigurosa, pero inteligible, sobre la forma actual de entender el cáncer, hasta qué punto se puede prevenir y curar, y por qué este no se trata de la misma manera ahora que hace diez o veinte años. La autora aborda las preguntas que casi todos nos hacemos acerca del cáncer, especialmente si la enfermedad nos toca de cerca (lo que, tarde o temprano ocurrirá —directa o indirectamente—). Haremos un rápido viaje a través del tiempo para asomarnos a la historia del conocimiento del cáncer y a los (tremendos) tratamientos del pasado. Ese viaje nos traerá al presente, al conocimiento y a los tratamientos actuales. Hablaremos de las ventajas de las nuevas técnicas de diagnóstico y de los tratamientos más punteros. Y también de los graves inconvenientes y de lo que aún no sabemos. Por último, nos asomaremos al futuro de la prevención, del diagnóstico y del tratamiento del cáncer. EL LIBRO EXPLICA: • Cómo y por qué aparece el cáncer • En qué medida se puede evitar • Qué cánceres se pueden curar actualmente y cuáles no SOBRE LA AUTORA María I. Tapia es Doctora en Bioquímica y Biología Molecular. Ha desarrollado su carrera profesional durante más de veinte años en el sector farmacéutico y agroalimentario (regulación del metabolismo, desarrollo de nuevas vacunas, alimentación y salud, etc.). ESTO ENCONTRARÁS EN EL LIBRO PARTE 1 LA CÉLULA OPORTUNISTA 1. Deconstruyendo la vida 2. El sentido de la vida es generar más vida 3. Nosotros, los de entonces, ya no somos los mismos 4. El cuerpo humano es una conversación entre células 5. Esa molécula no tan estúpida 6. Los genes se «encienden» y se «apagan» 7. Qué no es el cáncer 8. La naturaleza desbocada 9. ¿Cómo una célula normal se transforma en cancerosa? 10. ¿Cuántas mutaciones se necesitan para causar un cáncer? 11. La enfermedad de las vías 12. Otro camino hacia el cáncer 13. Recapitulación 14. Hay un cáncer latente en cada uno de nosotros PARTE 2 TRATAMIENTOS 15. Una historia increíble 16. ¿Por qué los científicos no han curado el cáncer todavía? 17. Radioterapia 18. Quimioterapia 19. Terapias dirigidas 20. Destruir la célula cancerosa 21. Reparar la célula cancerosa 22. Inmunoterapia: la gran esperanza 23. Medicina personalizada 24. Biopsia líquida 25. El problema económico 26. Las farmacéuticas 27. Más problemas 28. Las dos caras de la moneda 29. ¿Se podrán curar todos los cánceres algún día? PARTE 3 ¿Y AHORA QUÉ? 30. ¿Qué pasa cuando nos detectan un cáncer? 31. El futuro ¿Por qué he escrito este libro?
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates