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Measurements of the intracellular distribution of the activation of foils by neutrons were made in lattices of 1/4-inch diameter, 1.03% U-235, uranium rods moderated by heavy water, with bare and cadmium-covered foils of gold, depleted uranium, lutetium, europium and copper. The measurements were made in the M.I.T. Heavy Water Lattice Facility with source neutrons from the M.I.T. Reactor. Two lattices were studied in detail in this work. The more closely packed lattice had a triangular spacing of 1.25 inches, and the less closely packed lattice had a triangular spacing of 2.5 inches. The results of the experiments were compared to one-dimensional, 30-energy group, THERMOS calculations based on the available energy exchange kernels. The comparison indicated that the approximation that the hexagonal cell may be replaced by an equivalent circular cell (the Wigner-Seitz approximation) can lead to serious discrepancies in closely packed lattices moderated by heavy water. A modified one-dimensional, and a two-dimensional, calculation were shown to predict the intracellular activation distribution in the closely packed lattice. An analytical treatment of the problem of the flux perturbation in a foil was developed and compared to the experimental results obtained by using gold foils of four different thicknesses in the lattice cell; the method was shown to be adequate. An analytical method to treat the effect of leakage from an exponential assembly was formulated; the results indicated that only in small exponential assemblies would leakage be a significant problem in intracellular flux measurements. A method was developed to predict the cadmium ratio of the foils used in the lattice cell; comparison with available measurements with gold foils indicated good agreement between theory and experiment, except for a lattice having very large ratios of moderator volume, to fuel volume, e.g., 100:1. Calculations of the fuel disadvantage factor by the method of successive generations for gold, lutetium and europium detector foils were compared to the results of THERMOS calculations, because THERMOS was shown to predict the experimental distributions. The comparison indicated that the method of successive generations is a good alternative to the THERMOS calculation, if all that is required is 17 and the thermal utilization.