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Provides an up-to-date, authoritative, and challenging review of the ecology and evolution of infectious diseases, focusing on low-income countries for effective public health applications and outcomes.
A combination of ecology and epidemiology in natural, unmanaged, animal and plant populations.
Genetics and Evolution of Infectious Diseases, Third Edition discusses the evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world where they must confront the dual burden of death and disability due to infectious and chronic illnesses. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases, in recent decades the world has witnessed the emergence of the human immunodeficiency virus (HIV) and the COVID-19 pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. Fully updated and revised, this new edition presents the consequences of such diseases, the evolution of infectious diseases, the genetics of host-pathogen relationship, and the control and prevention strategies that are, or can be, developed. This book offers valuable information to biomedical researchers, clinicians, public health practitioners, decisions-makers, and students and postgraduates studying infectious diseases, microbiology, medicine, and public health that is relevant to the control and prevention of neglected and emerging worldwide diseases. - Takes an integrated approach to infectious diseases - Provides the latest developments in the field of infectious diseases - Focuses on the contribution of evolutionary and genomic studies for the study and control of transmissible diseases - Includes updated and revised contributions from leading authorities, along with six new chapters
Recent progress in the field of wildlife disease ecology demonstrates that infectious disease plays a crucial role in the lives of wild animals. Parasites and pathogens should be especially important for social animals in which high contact among individuals increases the potential for disease spread. As one of the best studied mammalian groups, primates offer a unique opportunity to examine how complex behaviours (including social organization) influence the risk of acquiring infectiousdiseases, and the defences used by animals to avoid infection. This book explores the correlates of disease risk in primates, including not only social and mating behaviour but also diet, habitat use, life history, geography and phylogeny. The authors examine how a core set of host and parasite traits influence patterns of parasitism at three levels of biological organization: among individuals, among populations, and across species. A major goal is to synthesize, for the first time, fourdisparate areas of research: primate behavioural ecology, parasite biology, wildlife epidemiology, and the behavioural and immune defences employed by animals to counter infectious disease. Throughout, the authors provide an overview of the remarkable diversity of infectious agents found in wild primate populations. Additional chapters consider how knowledge of infectious diseases in wild primates can inform efforts focused on primate conservation and human health. More generally, this book identifies infectious disease as an important frontier in our understanding of primate behaviour and ecology. It highlights future challenges for testing the links between host and parasite traits, including hypotheses for the effects of disease on primate social and mating systems.
Emerging infectious diseases pose an increasingly serious threat to a number of endangered or sensitive species and are increasingly recognized as one of the major factors driving species extinction. Despite the significant impact of pathogens on conservation, no single book has yet integrated the theoretical principles underlying disease transmission with the practical health considerations for helping wildlife professionals and conservation biologists to manage disease outbreaks and conserve biodiversity. This novel and accessible book starts with a foundational section focusing on the role of pathogens in natural ecosystems, the dynamics of transmission in different environments, and the factors driving wildlife disease outbreaks. It then moves on to more applied issues concerned with the acquisition of field data including sampling, experimental design and analysis, as well as diagnostic analyses in both the laboratory and field. Guidelines for effective modelling and data analysis follow, before a final section is devoted to disease prevention and control including the prevention of novel outbreaks, the use of diseases as biocontrol agents, and the associated issues of ethics, public communication, and outreach. Infectious Disease Ecology and Conservation is primarily aimed at advanced undergraduates, graduate students, and established researchers in the fields of conservation biology, disease ecology, population ecology, and veterinary science. It will also be a valuable reference for conservation practitioners, land managers, and wildlife professionals who are required to deal with disease outbreak problems.
Findings from the field of evolutionary biology are yielding dramatic insights for health scientists, especially those involved in the fight against infectious diseases. This book is the first in-depth presentation of these insights. In detailing why the pathogens that cause malaria, smallpox, tuberculosis, and AIDS have their special kinds of deadliness, the book shows how efforts to control virtually all diseases would benefit from a more thorough application of evolutionary principles. When viewed from a Darwinian perspective, a pathogen is not simply a disease-causing agent, it is a self-replicating organism driven by evolutionary pressures to pass on as many copies of itself as possible. In this context, so-called "cultural vectors"--those aspects of human behavior and the human environment that allow spread of disease from immobilized people--become more important than ever. Interventions to control diseases don't simply hinder their spread but can cause pathogens and the diseases they engender to evolve into more benign forms. In fact, the union of health science with evolutionary biology offers an entirely new dimension to policy making, as the possibility of determining the future course of many diseases becomes a reality. By presenting the first detailed explanation of an evolutionary perspective on infectious disease, the author has achieved a genuine milestone in the synthesis of health science, epidemiology, and evolutionary biology. Written in a clear, accessible style, it is intended for a wide readership among professionals in these fields and general readers interested in science and health.
News headlines are forever reporting diseases that take huge tolls on humans, wildlife, domestic animals, and both cultivated and native plants worldwide. These diseases can also completely transform the ecosystems that feed us and provide us with other critical benefits, from flood control to water purification. And yet diseases sometimes serve to maintain the structure and function of the ecosystems on which humans depend. Gathering thirteen essays by forty leading experts who convened at the Cary Conference at the Institute of Ecosystem Studies in 2005, this book develops an integrated framework for understanding where these diseases come from, what ecological factors influence their impacts, and how they in turn influence ecosystem dynamics. It marks the first comprehensive and in-depth exploration of the rich and complex linkages between ecology and disease, and provides conceptual underpinnings to understand and ameliorate epidemics. It also sheds light on the roles that diseases play in ecosystems, bringing vital new insights to landscape management issues in particular. While the ecological context is a key piece of the puzzle, effective control and understanding of diseases requires the interaction of professionals in medicine, epidemiology, veterinary medicine, forestry, agriculture, and ecology. The essential resource on the subject, Infectious Disease Ecology seeks to bridge these fields with an ecological approach that focuses on systems thinking and complex interactions.
Many ancient diseases with a long history of afflicting mankind such as Tuberculosis and Malaria are now re-emerging. Greenblatt brings together palaeopathologists, anthropologists, molecular biologists and modern infectious disease specialists to examine this phenomenon. New techniques allow us to detect ancient pathogen DNA and other biomarkers, in effect the chemical 'signatures' of pathogens. These tools could help us develop strategies to combat modern emerging diseases. This book focuses on ancient diseases in order to bridge the gap that has for so long separated today's infectious disease specialists and the paleopathologists who describe pathology in skeletal and mummified remains. Linking these two research communities, and incorporating the views of anthropologists, medical ecologists and molecular/evolutionary biologists, will hopefully promote a better understanding of this complex but vitally important field. A more thorough knowledge of the impact of evolutionary biology on the host-parasite relationship may even enable us to coexist with these pathogenic micro-organisms. The book is intended to stimulate debate and co-operation between infectious disease specialists, medical researchers, archaeologists, anthropologists and evolutionary biologists.
Introduces readers to key case studies that illustrate how theory and data can be integrated to understand wildlife disease ecology.
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